Skip to main content

Zusammenfassung

Leitsymptom der Ösophagusstenosen ist die Dysphagie. Da benigne Stenosen gewöhnlich über Monate und Jahre fortbestehen, adaptieren sich die Patienten meistens. Durch Anpassung der Ernährungsweise werden oft geringere Schluckbeschwerden empfunden als es der objektive Befund erwarten läßt. Die Symptomatik läßt sich in der Regel prompt mittels Bougierung bessern. Bislang verfügen jedoch nur wenige Internisten über größere Erfahrungen mit der Bougierungsbehandlung. Eine regelmäßige Nachbetreuung wird deswegen kaum geübt. Im folgenden soll über unsere Erfahrungen bezüglich Praktikabilität und Effektivität mit verschiedenen Bougierungsmethoden berichtet werden. Die Ergebnisse zeigen, daß die Bougierungstherapie benigner Ösophagusstenosen eine sehr wirksame und risikoarme Behandlungsmethode ist, die eine weitere Verbreitung verdient.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 64.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Zusammenfassung

  1. Berges W, Wienbeck M (1980) Dtsch Med Wochenschr 105: 1012–1013

    Article  PubMed  CAS  Google Scholar 

  2. Lanza FL, Graham DY (1978) JAMA 240: 844–847

    Article  PubMed  CAS  Google Scholar 

  3. Lux G, Lederer P, Femppel J, Rösch W, Domschke W (1980) Spontaneous and 13-nle-motilin-induced interdigestive motor activity of esophagus, stomach and small intestine in man. In: 9th International Symposium on Gastrointestinal Motility, Iowa City. Raven Press, New York

    Google Scholar 

  4. Lux G, Lederer P, Femppel J, Schmack B, Rösch W, Domschke W (1980) Motor and secretor activity of the duodenal complex; an integrated function. In: 9th International symposium on Gastrointestinal Motility, Iowa City. Raven Press, New York

    Google Scholar 

  5. Dent J (1976) A new technique for continuous sphincter pressure measurement. Gastroenterology 71: 263

    PubMed  CAS  Google Scholar 

  6. Keane FB, DiMagno EP, Dozois RR, Go VLW (1979) Relations of canine interdigestive pancreatic and biliary secretions to motor activity. Gastroenterology 76: 1167

    Google Scholar 

  7. Malagelada JR (1979) Physiologic basis and clinical significance of gastric emptying disorders. Dig Dis Sci 24: 657–661

    Article  PubMed  CAS  Google Scholar 

  8. Hunt JN, Cash R, Newland P (1978) Energy density of food, gastric emptying, and obesity. Am J Clin Nutr 31: 259–260

    Google Scholar 

  9. Kasper H (1980) Ernährungsmedizin and Diätetik, 3. Aufl. Urban and Schwarzenberg, München

    Google Scholar 

  10. Holt S et al. (1979) Effect of gel fibre on gastric emptying and absorption of glucose and paracetamol. Lancet 1: 636–639

    Article  PubMed  CAS  Google Scholar 

  11. Ralphs DNL et al. (1978) Effect of a dietary fibre on gastric emptying in dumpers. Gut 19: A986

    Google Scholar 

  12. Baraona E, Lindenbaum J (1977) Metabolic effects of ethanol on the intestine. In: Lieber CS (ed) Metabolic aspects of alcoholism. University Park Press, Baltimore, pp 81–116

    Chapter  Google Scholar 

  13. Worthington-Roberts B (1980) Changes in intestinal passive permeation induced by alcohol. Les Colloques de I’INSERM, Alcohol and the gastrointestinal tract. INSERM 95: 507–518

    CAS  Google Scholar 

  14. Baraona E, Pirola RC, Lieber CS (1974) Small intestinal damage and changes in cell population produced by ethanol ingestion in the rat. Gastroenterology 66: 226–234

    CAS  Google Scholar 

  15. Wands JR, Carter EA, Bucher NLR, Isselbacher KJ (1979) Inhibition of hepatic regeneration in rats by acute and chronic ethanol intoxication. Gastroenterology 77: 528–531

    PubMed  CAS  Google Scholar 

  16. Lieber CS, DeCarli LM (1970) Quantitative relationship between the amount of dietary fat and the severity of the alcoholic fatty liver. Am J Clin Nutr 23: 474–478

    PubMed  CAS  Google Scholar 

  17. Takeuchi K, Johnson LR (1979) Pentagastrin protects against stress ulceration in the rat. Gastroenterology 76: 327–334

    PubMed  CAS  Google Scholar 

  18. Burton K (1956) A study of the conditions and mechanism of the diphenylamine reaction for the calorimetric estimation of deoxyribonucleic acid. Biochem J 62: 315–323

    PubMed  CAS  Google Scholar 

  19. Seitz HK, Korsten MA, Lieber CS (1979) Ethanol oxidation by intestinal microsomes: increased activity after chronic ethanol administration. Life Sci 25: 1443–1448

    Article  PubMed  CAS  Google Scholar 

  20. Carter EA, Isselbacher KJ (1973) Effect of ethanol on intestinal adenosine triphosphate ( ATP) content. Proc Soc Exp Biol Med 142: 1171–1177

    Article  PubMed  CAS  Google Scholar 

  21. Bonfils S, Mignon M (1980) Management of Zollinger-Ellison syndrome. In: Holtermüller K-H, Malagelada JR (eds) Advances in ulcer research. Excerpta Medica, International Congress Series 537, Amsterdam, pp 357–365

    Google Scholar 

  22. Code CF, Marlett JA (1975) The interdigestive myoelectric complex of the stomach and small bowel of dogs. J Physiol (Lond) 246: 283–309

    Google Scholar 

  23. Londong W, Londong V, Prechtl R, Evermann T (1979) Vergleichende Untersuchungen der Pirezepin-und Cimetidinwirkung auf Pepton-stimulierte Säuresekretion und Serumgastrin des Menschen. In: Blum AL, Hammer R (Hrsg) Die Behandlung des Ulcus pepticum mit Pirenzepin. Demter-Verlag, Gräfelfing, S 75–85

    Google Scholar 

  24. Lux G, Femppel J, Lederer PC, Rösch W, Domschke W (1979) Increased duodenal alkali load associated with the interdigestive myoelectric complex. Acta Hepatogastroenterol (Stuttg) 26: 166–169

    CAS  Google Scholar 

  25. Lux G, Lederer PC, Femppel J, Schmack B, Rösch W, Domschke W (1980) Motor and secretor activity of the duodenal interdigestive complex: an integrated function. In: Christensen J (ed) Gastrointestinal motility. Raven Press, New York, pp 311–318

    Google Scholar 

  26. Lux G, Lederer PC, Femppel J, Rösch W Domschke W (1980) Spontaneous and 13-NLE-Motilin-induced interdigestive motor activity of esophagus, stomach and small intestine in man. In: Christensen J (ed) Gastrointestinal motility. Raven Press, New York, pp 269–277

    Google Scholar 

  27. Szurszewski JH (1969) A migrating electric complex of the canine small intestine. Am J Physiol 217: 1751–1763

    Google Scholar 

  28. Vantrappen G, Janssens J, Hellemans J, Ghoos Y (1977) The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59: 1158–1166

    Article  PubMed  CAS  Google Scholar 

  29. Archibald LH, Moody FG, Simons M (1974) Effect of isoproternol on canine gastric acid secretion and blood flow. Surg Forum 25: 409–411

    PubMed  CAS  Google Scholar 

  30. Archibald LH, Moody FG, Simons M (1975) Comparison of gastric mucosal blood flow as determined by aminopyrine clearance and y-labelled microspheres. Gastroenterology 69: 630–635

    PubMed  CAS  Google Scholar 

  31. Cowley DJ, Code CF (1970) Effects of secretory inhibitors on mucosal blood flow in nonsecreting stomach of conscious dogs. Am J Physiol 218: 270–274

    PubMed  CAS  Google Scholar 

  32. Fordtran JS, Walsh J (1973) Gastric acid secretion rate and buffer content of the stomach after eating. J Clin Invest 52: 645–657

    Article  PubMed  CAS  Google Scholar 

  33. Guth PH, Baumann H, Grossman MI et al. (1978) Measurement of gastric mucosal blood flow in man. Gastroenterology 74: 831–834

    PubMed  CAS  Google Scholar 

  34. Jacobson ED (1965) The circulation of the stomach. Gastroenterology 48: 85–109

    PubMed  CAS  Google Scholar 

  35. Jacobson ED, Linford RH, Grossman MI (1966) Gastric secretion in relation to mucosal blood flow studied by a clearance technique. J Clin Invest 45: 1–13

    Article  PubMed  CAS  Google Scholar 

  36. Jacobson ED, Swan KG, Grossman MI (1967) Blood flow and secretion in the stomach. Gastroenterology 52: 414–420

    PubMed  CAS  Google Scholar 

  37. Lam SK, Isenberg J, Grossman MI et al. (1980) Gastric acid secretion is abnormally sensitive to endogenous gastrin released after peptone test meals in duodenal ulcer patients. J Clin Invest 65: 555–562

    Article  PubMed  CAS  Google Scholar 

  38. Malawer SJ, Powell DW (1967) An improved turbidimetric analysis of polyethelene glycol utilizing an emulsifier. Gastroenterology 53: 250–256

    CAS  Google Scholar 

  39. Müller-Lissner SA, Sonnenberg A, Blum AL (1981) Does gastric aminopyrine clearance reflect gastric mucosal blood flow or parietal cell function? Gut 22: im Druck

    Google Scholar 

  40. Rudick J, Werther JL, Chapman ML et al. (1971) Mucosal blood flow in canine antral and fundic pouches. Gastroenterology 60: 263–271

    PubMed  CAS  Google Scholar 

  41. Shore PA, Brodie BB, Hogben CA (1975) The gastric secretion of drugs: A pH partition hypothesis. J Pharmacol Exp Ther 119: 361–369

    Google Scholar 

  42. Sonnenberg A, Blum AL (1980) Limitations to measurement of gastric mucosal blood flow by 14C-aminopyrine clearance. In: Fielding LP (ed) Gastro-intestinal mucosal blood flow. Churchill Livingstone, Edinburgh London New York, pp 43–58

    Google Scholar 

  43. Virchow R (1853) Historisches, Kritisches and Positives zur Lehre der Unterleibsaffektionen. Arch Pathol Anatom 5: 281–387

    Google Scholar 

  44. Walsh JH, Richardson CT, Fordtran JS (1975) pH dependence of acid secretion and gastrin release in normal and ulcer patients. J Clin Invest 55: 462–468

    Article  PubMed  CAS  Google Scholar 

  45. Wormsley KG, Grossman MI (1965) Maximal histalog test in control subjects and patients with peptic ulcer. Gut 6: 427–435

    Article  PubMed  CAS  Google Scholar 

  46. Zinner MJ, Kerr JC, Reynolds DG (1975) Adrenergic mechanisms in canine gastric circulation. Am J Physiol 229: 977–982

    PubMed  CAS  Google Scholar 

  47. Zinner MJ, Kerr JC, Reynolds DG (1976) Primate gastric circulation: Effects of catecholamines and adrenergic blockade. Am J Physiol 230: 346–350

    PubMed  CAS  Google Scholar 

  48. Arnold R, 1st M v, Minana I, Koop H (1980) Verhalten der antralen Gastrin (G)- and Somatostatin D)-Zellzahl sowie der immunoreaktiven Gastrin (IRG)- and Somatostatin (IRS)-Konzentration nach selektiv proximaler Vagotomie. Verh Dtsch Ges Inn Med 86: 849–851

    Google Scholar 

  49. Arnold R, Koop H, Creutzfeldt W (1980) Hormones and their role in ulcer disease. In: Holtermüller KH, Malagelada JR (eds) Advances in ulcer disease. Excerpta Medica, Amsterdam Oxford Princeton, pp 207–224

    Google Scholar 

  50. Berson SA, Yalow RS (1972) Radioimmunoassay in gastroenterology. Gastroenterology 62: 1061–1084

    PubMed  CAS  Google Scholar 

  51. Cowley DJ, Dymock IW, Boyes BE, Wilson RY, Stagg BH, Lewin MR, Polak JM, Pearse AGE (1973) Zollinger Ellison syndrome type I. Clinical and pathological correlations in a case. Gut 14: 25–29

    CAS  Google Scholar 

  52. Creutzfeldt W, Arnold R, Creutzfeldt C, Track NS (1975) Pathomorphologic, biochemical, and diagnostic aspects of gastrinomas ( Zollinger Ellison syndrome ). Hum Pathol 6: 47–76

    Article  PubMed  CAS  Google Scholar 

  53. DiMagno EP, Go VLW (1974) Malabsorption secondary to antral gastrin cell hyperplasia. Mayo Clin Proc 49: 727–730

    PubMed  CAS  Google Scholar 

  54. Ganguli PC, Polak JM, Pearse AGE, Elder JB, Hegarty M (1974) Antral-gastrin-cell hyperplasia in peptic ulcer disease. Lancet 1: 583–586

    Article  PubMed  CAS  Google Scholar 

  55. Hansky J (1974) Antral-gastrin-cell hyperplasia in peptic ulcer disease (letter). Lancet 1: 1344

    Article  PubMed  CAS  Google Scholar 

  56. Isenberg JI, Walsh JH, Grossman MI (1973) Zollinger-Ellison Syndrome. Gastroenterology 65: 140–165

    PubMed  CAS  Google Scholar 

  57. Lamers CBH, Ruland CM, Joosten HJM, Verkooyen HCM, Tongeren JHM van, Rehfeld JF (1978) Hypergastrinemia of antral origin in duodenal ulcer. Am J Dig Dis 23: 998–1002

    Article  PubMed  CAS  Google Scholar 

  58. Lamers CBH, Tongeren JHM van (1977) Comparative study of the value of the calcium, secretin and meal stimulated increase in serum gastrin to the diagnosis of the Zollinger-Ellison syndrome. Gut 18: 128–134

    Article  PubMed  CAS  Google Scholar 

  59. McGuigan JE, Wolfe MM (1980) Secretin injection test in the diagnosis of gastrinoma. Gastroenterology 79: 1324–1331

    PubMed  CAS  Google Scholar 

  60. Polak JM, Stagg B, Pearse AGE (1972) Two types of Zollinger Ellison syndrome: Immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states. Gut 13: 501–512

    CAS  Google Scholar 

  61. Russell RCG, Bloom SR, Davies WA, Polak JM, Reed PI (1975) Hypergastrinemio in a peptic ulcer patient with antral gastrin cell hyperplasia. Br Med J 4: 441

    Article  Google Scholar 

  62. Straus E, Yalow RS (1975) Differential diagnosis of hypergastrinemia. In: Thompson JC (ed) Gastrointestinal hormones. University of Texas Press, Austin, pp 99–113

    Google Scholar 

  63. Austen FK (1979) Biologic implications of the structural and functional characteristics of the chemical mediators of immediate-type hypersensitivity. In: The Harvey lectures, vol 73. Academic Press, New York, p 93

    Google Scholar 

  64. Ehinger B, Owman C, Sporrong B (1968) Histochemical demonstration of histamine in paraffine sections by a fluorescance method. Biochem Pharmacol 17: 1977

    Article  Google Scholar 

  65. Lichtenstein LM (1975) The mechanism of basophile histamine release induced by antigen and by the calcium ionophore A 23187. J Immunol 144: 1692

    Google Scholar 

  66. Lorenz W, Reimann H-J, Barth H, Kusche J, Meyer R, Doenicke A, Hutzel M (1972) A sensitive and specific method for the determination of histamine in human whole blood and plasma. Hoppe Seylers Z Physiol Chem 353: 911

    Article  PubMed  CAS  Google Scholar 

  67. Reimann H-J, Lorenz W, Fischer M, Froelich R, Meyer H-J, Schmal A (1977) Histamine and acute haemorrhagic lesions in rat gastric mucosa; Prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro. Agents Actions 7: 69

    Article  PubMed  CAS  Google Scholar 

  68. Reimann H-J, Swoboda K, Wendt P, Blümel G, Schmidt U, Rakette S, Ultsch B (1980) Die Wirkung des HDC-Blockers (+)-Catechin auf die menschliche Magenschleimhaut bei akuten und chronischen Erkrankungen. Verh Dtsch Ges Inn Med 86: 859–864

    Google Scholar 

  69. Ring J (1978) RIST, BRIST, RAST. Zur Serodiagnostik der allergischen Sofortreaktion. Dtsch Med Wochenschr 103: 365

    Article  PubMed  CAS  Google Scholar 

  70. Werner M (1960) Der intestinale Expositionstest. Internist 1: 202

    Google Scholar 

  71. Werner M, Ruppert V (1979) Praktische Allergiediagnostik. Thieme, Stuttgart

    Google Scholar 

  72. Becker H, Ruoff H-J (1979) Pentagastrin activation of adenyl-cyclase in human gastric biopsy specimens. Experientia 35: 781

    Article  PubMed  CAS  Google Scholar 

  73. Jacobsen ED, Thompson WJ (1976) Cyclic AMP and gastric secretion: the illusive second messenger. Adv Cyclic Nucleotide Res 7: 199

    Google Scholar 

  74. Miederer SE (1977) Die Histotopographie der Magenschleimhaut. Monographie. Thieme, Stuttgart

    Google Scholar 

  75. Ruoff H-J, Painz B, Becker M, Rack M, Sewing K-F, Malchow H (1979) Adenylate cyclase in human gastric mucosa: its activation by histamine in morphologically different biopsy specimens. Klin Wochenschr 57: 725

    Article  PubMed  CAS  Google Scholar 

  76. Simon B, Czygen P, Fröhlich W, Kather H (1977) Topographical studies on histamine and adrenaline sensitive adenylate cyclases in gastric and duodenal mucosa of human beings. Digestion 16: 185

    Article  Google Scholar 

  77. Simon B, Kather H, Kommerell B (1978) Effects of prostaglandins and their methylated analogues upon human adenylate cyclase in the upper gastrointestinal tract. Digestion 17: 547

    Article  Google Scholar 

  78. Soll AH (1979) Hormonal control of parietal cell function. World J Surg 3: 441

    Article  PubMed  CAS  Google Scholar 

  79. Andersson S, Grossman MI (1965) Profile of pH, pressure and potential difference at gastro-duodenal junction in man. Gastroenterology 49: 364

    PubMed  CAS  Google Scholar 

  80. Cohen MM, Cheung GI, Lyster DM (1980) Prevention of aspirin-induced faecal blood loss by prostaglandin E2. Gut 21: 602

    Article  PubMed  CAS  Google Scholar 

  81. Johannson C, Kollberg B, Nordemar R, Bergstrom S (1979) Mucosal cytoprotection by prostaglandin E2. Lancet 1: 317

    Article  Google Scholar 

  82. Müller P, Fischer N, Kather H, Simon B (1981) Prevention of aspirin-induced drop in gastric PD with 16,16-dimethyl-Prostaglandin E2. Lancet 1: 333–334

    Article  PubMed  Google Scholar 

  83. Müller P, Fischer N, Kather H, Simon B (1981) The cytoprotective effect of 16,16-dimethyl-prostaglandin E2 on bile salt induced damage to the human stomach. Br J Clin Pharmacol (in press)

    Google Scholar 

  84. Robert A, Nezamis JE, Lancaster C, Hanchar AJ (1979) Cytoprotection by prostaglandins in rats: prevention of gastric necrosis produced by alcohol, HCI, NaOH and thermal injury. Gastroenterology 77: 433

    PubMed  CAS  Google Scholar 

  85. Robert A (1967) Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins. In: Samuelsson B, Paoletti R (eds) Advances in prostaglandin and thromboxane research. Raven Press, New York, pp 507–520

    Google Scholar 

  86. Robert A, Nezamis JE, Lancaster C, Hanchar AJ (1979) Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis by alcohol, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 77: 433–443

    PubMed  CAS  Google Scholar 

  87. Miller TA, Jacobson ED (1979) Gastrointestinal cytoprotection by prostaglandins. Gut 20: 75–87

    Article  PubMed  CAS  Google Scholar 

  88. Johansson C, Kollberg B, Nordemar R, Samuelsson K, Bergström S (1980) Protective effect of prostaglandin E2 in the gastrointestinal tract during indomethacin treatment of rheumatic disease. Gastroenterology 78: 479–483

    PubMed  CAS  Google Scholar 

  89. Cohen MM (1978) Mucosal cytoprotection by prostaglandin E2. Lancet 2: 1253–1254

    Article  PubMed  CAS  Google Scholar 

  90. Fung WP, Karim SMM, Tye CY (1974) Effect of 15(R)15 methyl prostaglandin E2 methylester on healing of gastric ulcers. Lancet 2: 10–12

    Article  PubMed  CAS  Google Scholar 

  91. Fung PW, Karim SMM (1976) Effect of prostaglandin E2 on the healing of gastric ulcer: a double-blind endoscopie trial. Aust NZ J Med 6: 121–122

    Article  CAS  Google Scholar 

  92. Rybicka J, Gibinski K (1978) Methyl-prostaglandin analogues for healing of gastro-duodenal ulcers. Scand J Gastroenterol 13: 155–159

    Article  PubMed  CAS  Google Scholar 

  93. Bennett A, Stamford IF, Unger WG (1973) Prostaglandin E2 and gastric acid secretion in man. J Physiol 229: 349–360

    PubMed  CAS  Google Scholar 

  94. Peskar BM, Seyberth H, Peskar BA (1980) Synthesis and metabolism of prostaglandins by human gastric mucosa. In: Samuelsson B, Paoletti R (eds) Advances in prostaglandin and thromboxane research, vol 8. Raven Press, New York, pp 1511–1514

    Google Scholar 

  95. Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (New Biol) 231: 232–235

    Article  CAS  Google Scholar 

  96. Peskar BM (1977) On the synthesis of prostaglandins by human gastric mucosa and its modification by drugs. Biochim Biophys Acta 487: 307–314

    Article  PubMed  CAS  Google Scholar 

  97. Flower RJ, Vane JR (1972) Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature 240: 410

    Article  PubMed  CAS  Google Scholar 

  98. Woodbury DM, Fingl E (1975) Analgesic-antipytetics, anti-inflammatory agents and drugs employed in the therapy of gout. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, vol 5. MacMillan Publ. Co., New York, pp 325–358

    Google Scholar 

  99. Bustad LK, McClelland RK (1966) Swine in biomedical research. US Atomic Energy Commission and Battelle Memorial Institute, Frayne, Seattle

    Google Scholar 

  100. Muggenburg BA, McNutt SH, Kowalczyk T (1964) Pathology of gastric ulcers in swine. Am J Vet Res 25: 1354–1365

    Google Scholar 

  101. Rainsford KD (1978) Gastric mucosal ulceration induced in pigs by tablets but not suspensions or solutions of aspirin. J Pharm Pharmacol 30: 129–131

    Article  PubMed  CAS  Google Scholar 

  102. Rainsford KD, Peskar BM (1979) Relationship between gastric ulceration and mucosal prostaglandin concentrations following chronic oral administration of aspirin preparations to pigs. In: Brune K, Baggiolini M (eds) Arachidonic acid metabolism in inflammation and thrombosis. Agents Actions [Suppl] 4: 293–297

    Google Scholar 

  103. Jaffe BM, Behrman HR, Parker CW (1973) Radioimmunoassay measurement of prostaglandin E, A and F in human plasma. J Clin Invest 52: 398–504

    Article  PubMed  CAS  Google Scholar 

  104. Peskar BA, Anhut K, Kröner EE, Peskar BM (1978) Development, specificity and some applications of radioimmunoassays for prostaglandins and related compounds. In: Tillement JP (ed) Advances in pharmacology and therapeutics, vol 7. Pergamon Press, Oxford New York, pp 275–386

    Google Scholar 

  105. Peskar BA, Steffens Ch, Peskar BM (1979) Radioimmunoassay of 6-keto-PGFia in biological material. In: Albertini A, Daprada M, Peskar BA (eds) Radioimmunoassay of drugs and hormones. Elsevier-North Holland Biomed. Press, Amsterdam New York Oxford, pp 239–250

    Google Scholar 

  106. Rainsford KD, Peskar BM, Brune K (1981) Relationship between inhibition of prostaglandin production and gastric mucosal damage induced by anti-inflammatory drugs may depend on type of drugs and species. J Pharm Pharmacol 33: 127–128

    Article  PubMed  CAS  Google Scholar 

  107. Whittle BRA, Higgs GA, Eakins KE, Moncada S, Vane JR (1980) Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Nature 284: 271–273

    Article  PubMed  CAS  Google Scholar 

  108. Flower RJ, Vane JR (1974) Some pharmacologic and biochemical aspects of prostaglandin biosynthesis and its inhibition. In: Robinson HJ, Vane JR (eds) Prostaglandin synthetase inhibitors. Raven Press, New York, pp 9–18

    Google Scholar 

  109. Brune K, Gubler H, Schweitzer A (1979) Autoradiographic methods for the evaluation of ulcerogenic effects of anti-inflammatory drugs. Pharmacol Ther [B] 5: 199–207

    Article  CAS  Google Scholar 

  110. Auer IO et. al. (1979) Gut 20: 261–268

    Article  PubMed  CAS  Google Scholar 

  111. Beck JD et al. (1980) Am J Hematol 8: 185–189

    Article  Google Scholar 

  112. Biberfeld G et al. (1979) Arthritis Rheum 22: 978–982

    Article  PubMed  CAS  Google Scholar 

  113. Bird AG, Britton MD (1976) Gastroenterology 71: 926–932

    Google Scholar 

  114. Cobleigh MA et al. (1980) J Natl Cancer Inst 64: 1041–1045

    PubMed  CAS  Google Scholar 

  115. Dopp AC et al. (1980) Gastroenterology 79: 276–282

    PubMed  CAS  Google Scholar 

  116. Hayward AR et al. (1978) J Immunol 121: 1–5

    PubMed  CAS  Google Scholar 

  117. Meyers S et al. (1976) Gut 17: 911–915

    Article  PubMed  CAS  Google Scholar 

  118. Moretta L et al. (1977) Eur J Immunol 7: 696–700

    Article  PubMed  CAS  Google Scholar 

  119. Pichler WJ et al. (1978) J Immunol 121: 1540–1548

    PubMed  CAS  Google Scholar 

  120. Sachar DB et al. (1976) Ann NY Acad Sci 278: 565–573

    Article  PubMed  CAS  Google Scholar 

  121. Strickland RG et al. (1974) Gastroenterology 67: 569–577

    PubMed  CAS  Google Scholar 

  122. Thayer WR et al. (1976) Gastroenterology 71: 379–384

    PubMed  Google Scholar 

  123. Victorino, Hodgson (1980) Clin Exp Immunol 14: 156–165

    Google Scholar 

  124. Gupta S, et al. (1979) Cell Immunol 44: 242–251

    Article  PubMed  CAS  Google Scholar 

  125. Gupta S, Good RA (1977) Clin Exp Immunol 30: 222–228

    PubMed  CAS  Google Scholar 

  126. Gupta, S, Good, RA (1978) Clin Immunol Immunopathol 11: 292–302

    Article  PubMed  CAS  Google Scholar 

  127. Gupta Set al. (1979) Clin Immunol Immunopathol 14: 86–95

    Article  PubMed  CAS  Google Scholar 

  128. Gupta Set al. (1979) Clin Exp Immunol 38: 342–347

    PubMed  CAS  Google Scholar 

  129. Gupta S, Safai B, Good RA (1979) Cell Immunol 44: 242–251

    Article  PubMed  CAS  Google Scholar 

  130. Bernier JJ, Florent CH, Desmazures CH, Aymes CH, L’Hirondel CH (1978) Diagnosis of protein-losing enteropathy by gastrointestinal clearance of alpha -antitrypsin. Lancet 2: 763–764

    Article  PubMed  CAS  Google Scholar 

  131. Best W, Becktel JM, Singleton JM, Kern K (1978) Development of a Crohn’s disease activity index. National Cooperative Crohn’s disease study. Gastroenterology 70: 439

    Google Scholar 

  132. Crossley JR, Elliot RB (1977) Simple method for diagnosing protein-losing enteropathies. Br Med J 1: 428–429

    Article  PubMed  CAS  Google Scholar 

  133. Heaney MR, Fields J, Carter RA, Thompson RA, Asquith P (1979) Is fecal alphas-antitrypsin excretion a reliable screening test for protein-losing enteropathy? Lancet 2: 1161–1162

    Article  Google Scholar 

  134. Keaney NP, Kelleher J (1980) Fecal excretion of alphas-antitrypsin in protein-losing enteropathy. Lancet 1: 242

    Google Scholar 

  135. Allan R, Cooke WT (1977) Evaluation of metronidazole in the management of Crohn’s disease. Gut 18: A422

    Google Scholar 

  136. Ammann RW, Müller-Schoop J, Knoblauch M (1978) Therapie des Morbus Crohn im akuten Schub mit Ornidazol ( Tiberal ). Schweiz Med Wochenschr 108: 1075

    PubMed  CAS  Google Scholar 

  137. Beard M, Kenneth L, O’Fallon W, Kurland L, Dockerty M (1979) Lack of evidence for cancer due to use of metronidazole. N Engl J Med 301: 519

    Article  PubMed  CAS  Google Scholar 

  138. Beard C (1980) Cancer after Metronidazole. N Engl J Med 302: 520

    Article  Google Scholar 

  139. Bernstein LH, Frank MS, Brandt LJ, Boley SJ (1980) Healing of perineal Crohn’s disease with metronidazole. Gastroenterology 79: 357

    PubMed  CAS  Google Scholar 

  140. Best WR, Becktel JM, Singleton JW, Kern F (1976) National Cooperative Crohn’s Disease Study. Development of a Crohn’s disease activity index. Gastroenterology 70: 439

    CAS  Google Scholar 

  141. Blichfeldt P, Blomhoff JP, Myhre E, Gjone E (1978) Metronidazole in Crohn’s disease, a double blind cross-over clinical trial. Scand J Gastroenterol 13: 123

    Article  PubMed  CAS  Google Scholar 

  142. Davies PS, Rhodes J, Heatley RV, Owan E (1977) Metronidazole in the treatment of chronic proctitis: a controlled trial. Gut 18: 680

    Article  PubMed  CAS  Google Scholar 

  143. Friedman GD (1980) Cancer after metronidazole. N Engl J Med 302: 519

    Article  PubMed  CAS  Google Scholar 

  144. Goldmann P (1980) Metronidazole. N Engl J Med 303: 1212

    Article  Google Scholar 

  145. Hartley-Asp B (1979) Mutagenicity of metronidazole. Lancet 1: 275

    Article  PubMed  CAS  Google Scholar 

  146. Järnerot G, Ursing B, Alm T, Barany F, Bergelin I, Ganrot-Norlin K, Krause U, Krook A, Rosen A (1981) Treatment of active Crohn’s disease with metronidazole or sulphasalazine. A preliminary report of a double blind controlled trial (CCDSS) (in press)

    Google Scholar 

  147. Kagnoff MF (1978) On the etiology of Crohn’s disease. Gastroenterology 75: 526

    PubMed  CAS  Google Scholar 

  148. Kasper H, Sommer H, Kühn HA (1979) Therapy of Crohn’s disease with metronidazole An uncontrolled trial. Acta Hepatogastroenterol (Stuttg) 26: 217

    CAS  Google Scholar 

  149. Legator MS, Connor RH, Stoeckel M (1975) Detection of mutagenic activity of metronidazole and niridazole in body fluids of humans and mice. Science 189: 1118

    Article  Google Scholar 

  150. Mayberry J, Rhodes J, Matthews N, Wensinck F (1981) Serum antibodies to anaerobic coccoid rods in patients with Crohn’s disease or ulcerative colitis and in medical and nursing staff. Br Med J 282: 108

    Article  CAS  Google Scholar 

  151. Mitelman F, Hartley-Asp B, Ursing B (1976) Chromosome aberrations and metronidazole. Lancet 2: 802

    Article  PubMed  CAS  Google Scholar 

  152. Roe JE (1979) A critical appraisal of the toxicology of metronidazole. In: Philipps J, Collier J (eds) Metronidazole (Royal Society of Medicine. Internat. Congress and Symposium, Series no 18 ). Academic Press, London, p 215

    Google Scholar 

  153. Rustia M, Shubik P (1972) Induction of lung tumors and malignant lymphomas in mice by metronidazole. J Natl Cancer Inst 48: 721

    PubMed  CAS  Google Scholar 

  154. Rustia M, Shubik P (1979) Experimental induction of hepatomas, mammary tumors and other tumors with metronidazole in non inbred SAS: MRC (WI) BR rats. J Natl Cancer Inst 63: 863 —21. Sachar DB, Auslander MO, Walfish JS (1980) Aetiological theories of inflammatory bowel disease. Clin Gastroenterol 9: 231

    Google Scholar 

  155. Summer RW, Switz DM, Sessions JT, Jr, Becktel JM, Best WR, Kern F, Jr, Singleton JW (1979) National Cooperative Crohn’s Disease Study. Results of drug treatment. Gastroenterology 77: 847

    Google Scholar 

  156. Ursing B, Kamme C (1975) Metronidazole for Crohn’s disease. Lancet 1: 775

    Article  PubMed  CAS  Google Scholar 

  157. Winship DH, Summers RW, Singleton JW, Best WR, Becktel JM, Fink LF, Kern F, Jr (1979) National Cooperative Crohn’s Disease Study. Study design and conduct of the study. Gastroenterology 77: 829

    CAS  Google Scholar 

  158. Arvanitakis C (1979) Abnormalities of jejunal mucosal enzymes in ulcerative colitis and Crohn’s disease. Digestion 19: 259–266

    Article  PubMed  CAS  Google Scholar 

  159. Dunne WT, Cooke WT, Allan RN (1977) Enzymatic and morphometric evidence for Crohn’s disease as a diffuse lesion of the gastrointestinal tract. Gut 18: 290–294

    Article  PubMed  CAS  Google Scholar 

  160. Ferguson A, Logan RF, McDonald TT (1980) Increased mucosal damage during parasite infection in mice fed an elemental diet. Gut 21: 37–43

    Article  PubMed  CAS  Google Scholar 

  161. Gutschmidt S (1981)“In situ” determinations of apparent Km and Vmax of brush border disaccharidases along the villi of normal human jejuna] biopsy specimens. A quantitative histochemical study. Histochemistry (in press)

    Google Scholar 

  162. Gutschmidt S, Riecken EO (1981) Peptidase activities in different segments of rat small intestine. Gastroentérol Clin Biol (in press)

    Google Scholar 

  163. Gutschmidt S, Lorenz-Meyer H, Riecken EO, Menge H (1978) Mikrodensitometrische Untersuchungen zur Charakterisierung von Enzymaktivitäten am Gewebsschnitt mittels enzymhistochemischer Farbreaktionen. Acta Histochem (Jena) [Suppl] 20: 249–259

    Google Scholar 

  164. Gutschmidt S, Kaul W, Riecken EO (1979) A quantitative histochemical technique for the characterization of a-glucosidases in the brush-border membrane of rat jejunum. Histochemistry 63: 81–101

    Article  PubMed  CAS  Google Scholar 

  165. Kimura T, Shiosaka S, Yoshida A (1978) Effect of dietary amino acids on jejunal sucrase and Leucinaminopeptidase activities in rats. J Nutr 108: 1099–1103

    Google Scholar 

  166. Lehnert S (1979) Changes in growth kinetics of jejunal epithelium in mice maintained on an elemental diet. Cell Tissue Kinet 12: 239–248

    PubMed  CAS  Google Scholar 

  167. Lorenz-Meyer H, Fimmel C, Teutenberg M (1980) Der Effekt der Elementardiät auf Morphologie und Funktion der Dünndarmschleimhaut nach Langzeitexposition. Aktuel Ernähr Klin Prax 5: 74–80

    CAS  Google Scholar 

  168. Miller JM, Valbuena RM, Remigo MR (1978) Protection by an elemental diet against the toxic intestinal changes of 5-fluorouracil in rats. J Abdom Surg 20: 162–165

    Google Scholar 

  169. Mohiuddin M, Kramer S (1978) Therapeutic effect of an elemental diet on proline absorption across the irradiated rat small intestine. Radiat Res 75: 660–663

    Article  PubMed  CAS  Google Scholar 

  170. Morin CL, Ling V, Bourassa D (1980) Small intestinal and colonic changes induced by a chemically defined diet. Dig Dis Sci 25: 123–128

    Article  PubMed  CAS  Google Scholar 

  171. Nelson LM, Carmichael HA, Russell RI, Lee FD (1978) Small-intestinal changes induced by an elemental diet ( Vivionex) in normal rats. Clin Sci Mol Med 55: 509–511

    PubMed  CAS  Google Scholar 

  172. Prizont R, Hersh T, Floch MH (1970) Jejunal bacterial flora in chronic small bowel disease. I. Celiac disease. II. Regional enteritis. Am J Clin Nutr 23: 1602–1607

    CAS  Google Scholar 

  173. Riecken EO, Sahlfeld M, Lorenz-Meyer H (1976) Quantitative Untersuchungen zur dreidimensionalen Struktur der Dünndarmschleimhaut bei Gesunden und Patienten mit einheimischer Sprue. Dtsch Med Wochenschr 101: 51–53

    Article  PubMed  CAS  Google Scholar 

  174. Riecken EO, Zennek A, Lay A, Menge H (1979) Quantitative study of mucosal structure, enzyme activities and phenylalanine accumulation in jejunal biopsies of patients with early and late onset diabetes. Gut 20: 1001–1007

    Article  PubMed  CAS  Google Scholar 

  175. Rosenzweig NS (1975) Diet and intestinal enzyme adaptation: implications for gastrointestinal disorders. Am J Clin Nutr 28: 648–655

    Google Scholar 

  176. Russell RI, Atherton ST, Nelson LM, Robertson E, Lee FD (1979) Effect of an elemental diet ( Vivonex) on the absorption abnormalities and histological appearances of the jejunum in untreated adult coeliac disease. Digestion 19: 335–339

    Article  PubMed  CAS  Google Scholar 

  177. Steinhardt HJ, Hacker HW, Hoffmann R, Malchow H (1979) Absorption vollresorbierbarer Diäten im Dünndarm. Ein Vergleich von Peptid-, Aminosäure-und Formeldiäten. Z Gastroenterol 17: 597–598

    Google Scholar 

  178. Vidon N, Hecketsweiler P, Butel J, Bernier JJ (1978) Effect of continuous jejunal perfusion of elemental and complex nutritional solutions on pancreatic enzyme secretion in human subjects. Gut 19: 194–198

    Article  CAS  Google Scholar 

  179. Weiner R, Schmoz G, Hartig W, Matkowitz R, Conradi G (1980) Enterale Resorption unter oral bilanzierter synthetischer Diät (Berlamin). Klinisch experimentelle Untersuchungen mit dem modifizierten D-Xylose-Resorptionstest. Zentralbi Chir 105: 121–127

    CAS  Google Scholar 

  180. Young EA, Cioletti LA, Winborn WB, Traylor JB, Weser E (1980) Comparative study of nutritional adaptation to defined formula diets in rats. Am J Clin Nutr 33: 2106–2118

    PubMed  CAS  Google Scholar 

  181. Garrod AE (1909) Inborn erros of metabolism. Univ. Press, Oxford

    Google Scholar 

  182. Weiser MM, Douglas AP (1976) An alternative mechanism for gluten toxicity in coeliac disease. Lancet 1: 567

    Article  PubMed  CAS  Google Scholar 

  183. Douglas A, Peters TJ (1970) Peptide hydrolase activity of human intestinal mucosa in adult coeliac disease. Gut 11: 15

    Article  PubMed  CAS  Google Scholar 

  184. Asquith P, Thompson RA, Cooke WT (1969) Serum immunglobulins in adult celiac disease. Lancet 2: 129

    Article  PubMed  CAS  Google Scholar 

  185. Katz J, Kantor FS, Hershovic T (1968) Intestinal antibodies to wheat fractions in celiac disease. Ann Intern Med 69: 1149

    Article  PubMed  CAS  Google Scholar 

  186. Falchuk ZM, Rogentine GN, Strober W (1972) Predominance of histocompatibility antigen HL-A8 in patients with glutensitive enteropathy. J Clin Invest 51: 1602

    Article  PubMed  CAS  Google Scholar 

  187. Pena AS, Leeuwen AV, Hooff JP v, Rood JJ v (1976) HLA-DW3 associated with coeliac disease. Lancet 506

    Google Scholar 

  188. Betuel H, Gebuhrer L, Descos L, Bertrand J, Freycon F, Lepetit JC (1980) Coeliac disease and its association with HLA makers. Los Angeles

    Google Scholar 

  189. Falchuk ZM, Nelson DL, Katz AJ, Bernardin JE, Kasadra DD (1980) Gluten-sensitive enteropathy. Influence of histocompatibility type on gluten sensitivy in vitro. J Clin Invest 66: 227

    CAS  Google Scholar 

  190. Strominger JL, Mann DL, Parham P, Robb R, Springer T, Terhorst C (1977) Structur of HL-AA and B antigens isolated from cultured human lymphocytes. Cold Spring Harbor Symp Quant Biol 41: 323

    Article  PubMed  Google Scholar 

  191. Trier JS, Falchuk ZM, Carey MC, Schreiber DS (1978) Celiac sprue and refractory sprue. Gastroenterology 75: 307

    PubMed  CAS  Google Scholar 

  192. Albert E, Harms K, Bertele R, Andreas A, McNicholas A, Kuntz B, Scholz S, Schießl B, Wetzmüller H, Reissinger P, Weeser-Krell Ch (1978) B-cell alloantigens in coeliac disease. In: Perspectives in coeliac disease. Baltimore, p 123

    Google Scholar 

  193. Battle WM, Rubin MR, Cohen S, Snape WJ (1979) Gastrointestinal-motility dysfunction in amyloidosis. N Engl J Med 301: 24–25

    Article  PubMed  CAS  Google Scholar 

  194. Gilat T, Spiro HM (1968) Amyloidosis and the gut. Am J Dig Dis 13: 619–633

    Article  PubMed  CAS  Google Scholar 

  195. Gilat T, Revach M, Sohar E (1969) Deposition of amyloid in the gastrointestinal tract. Gut 10: 98–104

    Article  PubMed  CAS  Google Scholar 

  196. Missmahl HP, Gafni J (1964) Peri-collagen and peri-reticular amyloidosis their differentiation by polarization microscopy. Pathol Microbiol 27: 826–832

    CAS  Google Scholar 

  197. Rubenstein AE, Yahr MD, Mytilineou C, Bajaj K (1978) Peripheral catecholamine depletion in amyloid autonomic neuropathy. Mt Sinai J Med NY 45: 782–789

    CAS  Google Scholar 

  198. Schmidt H, Frühmorgen P, Riemann JF, Becker V (1981) Mucosal sugillations in the colon in secondary amyloidosis. Endoscopy (in press)

    Google Scholar 

  199. Schmidt H, Riemann JF (1981) Die Amyloidose des Magen-Darm-Traktes. Leber Magen Darm (im Druck )

    Google Scholar 

  200. Sohar E, Merker H-J, Missmahl H-P, Gafni J, Heller H (1967) Electron-microscope observations on peri-reticulin and pericollagen amyloidosis in rectal biopsies. J Pathol 94: 89–93

    Article  CAS  Google Scholar 

  201. Beretta KR, Güller R, Singeisen M, Stalder GA (1978) Okkultes Blut im Stuhl eine prospektive Studie zum Vergleich von Haemoccult und Fecatest. Schweiz Med Wochenschr 108: 1905–1907

    Google Scholar 

  202. Brault J, Favre H (1979) Evaluation en pratique hospitalière du fecatest, un nouvel examen de laboratoire pour la recherche de sang occulte dans les selles. Schweiz Med Wochenschr 109: 73–76

    CAS  Google Scholar 

  203. Greegor DH (1971) Occult blood testing for detection of asymptomatic colon cancer. Cancer 28: 131–134

    Article  PubMed  CAS  Google Scholar 

  204. Gilbertsen VA, Mchugh R, Schuman L, Williams SE (1980) The earlier detection of colorectal cancers. A Preliminary report of the results of the occult blood study. Cancer 45: 2899–2901

    CAS  Google Scholar 

  205. Herzog, P, Holtermüller KH, Preiss J, Fischer J, Ewe K, Michaelis J (1981) Fecal daily blood loss and anatomic location determines the accuracy of testing for occult blood in patients with colonic polyps. Gastroenterology (Abstract) 80 (in press)

    Google Scholar 

  206. Jaffe RM, Kasten B, Young DS, MacLowry JD (1975) False-negative stool occult blood tests caused by ingestion of ascorbic acid (vitamin C). Ann Intern Med 83: 824–826

    Article  PubMed  CAS  Google Scholar 

  207. Miller SF, Knight AR (1977) The early detection of colorectal cancer. Cancer 40: 945–949

    Article  PubMed  CAS  Google Scholar 

  208. Schewe S, Feifel G, Heldwein, Weinzierl M, Wolf W, Bolte HD, Konrad E (1979) Sensitivität des Haemoccult-Tests bei kolorektalen Tumoren. Dtsch Med Wochenschr 104: 253–256

    Article  PubMed  CAS  Google Scholar 

  209. Stroehlein JR, Fairbanks VF, McGill DB, Go VLW (1976) Haemoccult detection of fecal occult blood quantitated by radioassay. Am J Dig Dis 21: 841–844

    Article  PubMed  CAS  Google Scholar 

  210. Winawer SJ, Andrews M, Flehinger B, Sherlock P, Schottenfeld D, Miller G (1980) Progress report on controlled trial of fecal occult blood testing for the detection of colorectal neoplasia. Cancer 45: 2959–2964

    Article  PubMed  CAS  Google Scholar 

  211. Winchester DP, Shull JH, Scanlon EF, Murrell JV, Smeltzer C, Yrba P, Iden M, Streelman DH, Magpayo R, Dow JW, Sylvester J (1981) A mass screening program for colorectal cancer using chemical testing for occult blood in the stool. Cancer 45: 2955–2958

    Article  Google Scholar 

  212. Frimberger E, Frühmorgen P, Kühner W, Ottenjann R (1980) Salizylazosulfapyridin-Klysmen bei akuter linksseitiger Colitis ulcerosa. Ergebnisse einer Doppelblindstudie über ein neues Behandlungsprinzip. Munch Med Wochenschr 36: 1233

    Google Scholar 

  213. Miller B (1977) Wirkung und Nebenwirkungen der Therapie mit Salizylazosulfapyridin. In: Kremer K, Kivelitz H (Hrsg) Celitis ulcerosa. Thieme, Stuttgart, S 71

    Google Scholar 

  214. Moertel CG, Bargen JA (1959) A critical analysis of the use of salicylazosulfapyridin in chronic ulcerative colitis. Ann Intern Med 51: 789

    Google Scholar 

  215. Morrison LM (1953) Medical treatment of chronic ulcerative colitis. JAMA 153: 1580

    Google Scholar 

  216. Möller C, Kiviluoto O, Santavirta S, Holtz A (1978) Local treatment of ulcerative proctitis with salicylazosulphapyridine ( Salazopyrin) enema. Clin Trials J (Lond) 15: 199

    Google Scholar 

  217. Schulz U, Hanke P, Seige K (1973) Über die rektale Wirkung von Salazopyrin bei Colitis ulcerosa im doppelten Blindversuch. Wien Z Inn Med Grenzgeb 54: 185

    CAS  Google Scholar 

  218. Serebro H, Kay S, Javett S, Abrahams C (1977) Sulphasalzine rectal enemas: topical method of inducing remission of active ulcerative colitis affecting rectum and descending colon. Br Med J 12: 1264

    Article  Google Scholar 

  219. Svartz N (1968) Treatment of ulcerative colitis with Salazopyrin. Int Surg 50: 421

    PubMed  CAS  Google Scholar 

  220. Watkinson G (1961) Medical management of ulcerative colitis. Br Med J 1: 147

    Article  PubMed  CAS  Google Scholar 

  221. Watkinson G (1968) The medical treatment of ulcerative colitis. Postgrad Med J 44: 696

    Article  PubMed  CAS  Google Scholar 

  222. Watkinson G (1968) Ulcerative colitis. In: Goligher JC et al. (ed) Bailliére, Tindall and Cassell, London, pp 207–208

    Google Scholar 

  223. Kramer W, Buscher H-P, Gerok W, Kurz G (1979) Bile salt binding to serum components. Eur J Biochem 102: 1–9

    Article  PubMed  CAS  Google Scholar 

  224. Cronholm T, Sjövall J (1967) Bile acids in portal blood of rats fed different diets and cholestyramin. Eur J Biochem 2: 375–383

    Article  PubMed  CAS  Google Scholar 

  225. Stiehl A, Czygan P, Kommerell B (1978) Ursodeoxycholic acid versus chenodeoxycholic acid. Comparison of their effects on bile acids and bile lipid composition in patients with cholesterol gallstones. Gastroenterology 75: 1016–1020

    PubMed  CAS  Google Scholar 

  226. Carey MC (1978) Critical tables for calculating the cholesterol saturation in native bile. J Lipid Res 19: 945–955

    PubMed  CAS  Google Scholar 

  227. Corrigan OI, Su CC, Higuchi WI (1980) Mesophase formation during cholesterol dissolution in ursodeoxycholate-lecithin solution: new mechanism for gallstone dissolution in humans. J Pharm Sci 69: 869–870

    Article  PubMed  CAS  Google Scholar 

  228. Igimi H, Carey MC (1980) pH-Solubility relations of chenodeoxycholic and ursodeoxycholic acids: physical-chemical basis for dissimilar solution and membrane phenomena. J Lipid Res 21: 72–90

    PubMed  CAS  Google Scholar 

  229. Stiehl A, Raedsch R, Czygan P, Götz R, Männer CH, Walker S, Kommerell B (1980) Effects of biliary bile acid composition on biliary cholesterol saturation in gallstone patients treated with chenodeoxycholic acid and/or ursodeoxycholic acid. Gastroenterology 79: 1192–1198

    PubMed  CAS  Google Scholar 

  230. Narisawa T, Magaida NE, Weisenburger JH, Wynder EL (1974) Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N-nitro-N-nitrosoguanidine in rats. J Natl Cancer Inst 53: 1093–1097

    PubMed  CAS  Google Scholar 

  231. Craddock VM (1978) Cell proliferation and induction of liver cancer. In: Remmer H, Bolt HM, Bannaschi P, Popper H (eds) Primary liver tumors. MTP Press, Lancaster, pp 377–383

    Google Scholar 

  232. Danzinger RG, Hofman AF, Schoenfield LJ, Thistle JL (1972) Dissolution of cholesterol gallstones by chenodeoxycholic acid. N Engl J Med 289: 1–8

    Article  Google Scholar 

  233. Makino I, Shinozaki K, Yoshino K, Nakagawa S (1975) Dissolution of cholesterol gallstones by ursodeoxycholic acid. Jpn J Gastroenterol 76: 690–691

    Google Scholar 

  234. Banwell JG, Lepot A, Hanke DW, Sigdestad C (1978) Small intestinal epithelial renewall in the syrian hamster exposed to cholera enterotoxin. Gastroenterology 75: 717–722

    PubMed  CAS  Google Scholar 

  235. Takeuchi K, Johnson LR (1979) Pentagastrin protects against stress ulceration in rats. Gastroenterology 76: 327–334

    PubMed  CAS  Google Scholar 

  236. Burton K (1956) A study of the conditions and mechanism of the diphenylamine reaction for the calorimetric estimation of deoxyribonucleic acid. Biochem J 62: 315–323

    PubMed  CAS  Google Scholar 

  237. Binder HJ, Dobbins JW, Racusen LC, Whiting DS (1978) Effect of propranolol on ricinoleic acid-and deoxycholic acid-induced changes of intestinal electrolyte movement and mucosal permeability. Gastroenterology 75: 668–673

    PubMed  CAS  Google Scholar 

  238. Goerg KJ, Nell G, Sprecht W (1978) Correlation between the 51CrEDTA clearance and the secretion of fluid and electrolytes under the influence of deoxycholate ( DC) in the rat colon. Naunyn-Schmiedebergs Arch Pharmacol 302: R1

    Article  Google Scholar 

  239. Mekhjian HS, Philips HS, Hofmann AF (1971) Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man. J Clin Invest 50: 1569–1577

    Article  CAS  Google Scholar 

  240. Rummel W (1976) Wirkungen von Gallensäuren und Laxantien auf den mukosalen Transfer. Bull Schweiz Akad Med Wiss 32: 233–250

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

K. Miehlke

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Berges, W. et al. (1981). Gastroenterologie. In: Miehlke, K. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 87. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47092-9_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-47092-9_15

  • Publisher Name: J.F. Bergmann-Verlag, Munich

  • Print ISBN: 978-3-8070-0327-6

  • Online ISBN: 978-3-642-47092-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics