Zusammenfassung
Leitsymptom der Ösophagusstenosen ist die Dysphagie. Da benigne Stenosen gewöhnlich über Monate und Jahre fortbestehen, adaptieren sich die Patienten meistens. Durch Anpassung der Ernährungsweise werden oft geringere Schluckbeschwerden empfunden als es der objektive Befund erwarten läßt. Die Symptomatik läßt sich in der Regel prompt mittels Bougierung bessern. Bislang verfügen jedoch nur wenige Internisten über größere Erfahrungen mit der Bougierungsbehandlung. Eine regelmäßige Nachbetreuung wird deswegen kaum geübt. Im folgenden soll über unsere Erfahrungen bezüglich Praktikabilität und Effektivität mit verschiedenen Bougierungsmethoden berichtet werden. Die Ergebnisse zeigen, daß die Bougierungstherapie benigner Ösophagusstenosen eine sehr wirksame und risikoarme Behandlungsmethode ist, die eine weitere Verbreitung verdient.
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Zusammenfassung
Berges W, Wienbeck M (1980) Dtsch Med Wochenschr 105: 1012–1013
Lanza FL, Graham DY (1978) JAMA 240: 844–847
Lux G, Lederer P, Femppel J, Rösch W, Domschke W (1980) Spontaneous and 13-nle-motilin-induced interdigestive motor activity of esophagus, stomach and small intestine in man. In: 9th International Symposium on Gastrointestinal Motility, Iowa City. Raven Press, New York
Lux G, Lederer P, Femppel J, Schmack B, Rösch W, Domschke W (1980) Motor and secretor activity of the duodenal complex; an integrated function. In: 9th International symposium on Gastrointestinal Motility, Iowa City. Raven Press, New York
Dent J (1976) A new technique for continuous sphincter pressure measurement. Gastroenterology 71: 263
Keane FB, DiMagno EP, Dozois RR, Go VLW (1979) Relations of canine interdigestive pancreatic and biliary secretions to motor activity. Gastroenterology 76: 1167
Malagelada JR (1979) Physiologic basis and clinical significance of gastric emptying disorders. Dig Dis Sci 24: 657–661
Hunt JN, Cash R, Newland P (1978) Energy density of food, gastric emptying, and obesity. Am J Clin Nutr 31: 259–260
Kasper H (1980) Ernährungsmedizin and Diätetik, 3. Aufl. Urban and Schwarzenberg, München
Holt S et al. (1979) Effect of gel fibre on gastric emptying and absorption of glucose and paracetamol. Lancet 1: 636–639
Ralphs DNL et al. (1978) Effect of a dietary fibre on gastric emptying in dumpers. Gut 19: A986
Baraona E, Lindenbaum J (1977) Metabolic effects of ethanol on the intestine. In: Lieber CS (ed) Metabolic aspects of alcoholism. University Park Press, Baltimore, pp 81–116
Worthington-Roberts B (1980) Changes in intestinal passive permeation induced by alcohol. Les Colloques de I’INSERM, Alcohol and the gastrointestinal tract. INSERM 95: 507–518
Baraona E, Pirola RC, Lieber CS (1974) Small intestinal damage and changes in cell population produced by ethanol ingestion in the rat. Gastroenterology 66: 226–234
Wands JR, Carter EA, Bucher NLR, Isselbacher KJ (1979) Inhibition of hepatic regeneration in rats by acute and chronic ethanol intoxication. Gastroenterology 77: 528–531
Lieber CS, DeCarli LM (1970) Quantitative relationship between the amount of dietary fat and the severity of the alcoholic fatty liver. Am J Clin Nutr 23: 474–478
Takeuchi K, Johnson LR (1979) Pentagastrin protects against stress ulceration in the rat. Gastroenterology 76: 327–334
Burton K (1956) A study of the conditions and mechanism of the diphenylamine reaction for the calorimetric estimation of deoxyribonucleic acid. Biochem J 62: 315–323
Seitz HK, Korsten MA, Lieber CS (1979) Ethanol oxidation by intestinal microsomes: increased activity after chronic ethanol administration. Life Sci 25: 1443–1448
Carter EA, Isselbacher KJ (1973) Effect of ethanol on intestinal adenosine triphosphate ( ATP) content. Proc Soc Exp Biol Med 142: 1171–1177
Bonfils S, Mignon M (1980) Management of Zollinger-Ellison syndrome. In: Holtermüller K-H, Malagelada JR (eds) Advances in ulcer research. Excerpta Medica, International Congress Series 537, Amsterdam, pp 357–365
Code CF, Marlett JA (1975) The interdigestive myoelectric complex of the stomach and small bowel of dogs. J Physiol (Lond) 246: 283–309
Londong W, Londong V, Prechtl R, Evermann T (1979) Vergleichende Untersuchungen der Pirezepin-und Cimetidinwirkung auf Pepton-stimulierte Säuresekretion und Serumgastrin des Menschen. In: Blum AL, Hammer R (Hrsg) Die Behandlung des Ulcus pepticum mit Pirenzepin. Demter-Verlag, Gräfelfing, S 75–85
Lux G, Femppel J, Lederer PC, Rösch W, Domschke W (1979) Increased duodenal alkali load associated with the interdigestive myoelectric complex. Acta Hepatogastroenterol (Stuttg) 26: 166–169
Lux G, Lederer PC, Femppel J, Schmack B, Rösch W, Domschke W (1980) Motor and secretor activity of the duodenal interdigestive complex: an integrated function. In: Christensen J (ed) Gastrointestinal motility. Raven Press, New York, pp 311–318
Lux G, Lederer PC, Femppel J, Rösch W Domschke W (1980) Spontaneous and 13-NLE-Motilin-induced interdigestive motor activity of esophagus, stomach and small intestine in man. In: Christensen J (ed) Gastrointestinal motility. Raven Press, New York, pp 269–277
Szurszewski JH (1969) A migrating electric complex of the canine small intestine. Am J Physiol 217: 1751–1763
Vantrappen G, Janssens J, Hellemans J, Ghoos Y (1977) The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59: 1158–1166
Archibald LH, Moody FG, Simons M (1974) Effect of isoproternol on canine gastric acid secretion and blood flow. Surg Forum 25: 409–411
Archibald LH, Moody FG, Simons M (1975) Comparison of gastric mucosal blood flow as determined by aminopyrine clearance and y-labelled microspheres. Gastroenterology 69: 630–635
Cowley DJ, Code CF (1970) Effects of secretory inhibitors on mucosal blood flow in nonsecreting stomach of conscious dogs. Am J Physiol 218: 270–274
Fordtran JS, Walsh J (1973) Gastric acid secretion rate and buffer content of the stomach after eating. J Clin Invest 52: 645–657
Guth PH, Baumann H, Grossman MI et al. (1978) Measurement of gastric mucosal blood flow in man. Gastroenterology 74: 831–834
Jacobson ED (1965) The circulation of the stomach. Gastroenterology 48: 85–109
Jacobson ED, Linford RH, Grossman MI (1966) Gastric secretion in relation to mucosal blood flow studied by a clearance technique. J Clin Invest 45: 1–13
Jacobson ED, Swan KG, Grossman MI (1967) Blood flow and secretion in the stomach. Gastroenterology 52: 414–420
Lam SK, Isenberg J, Grossman MI et al. (1980) Gastric acid secretion is abnormally sensitive to endogenous gastrin released after peptone test meals in duodenal ulcer patients. J Clin Invest 65: 555–562
Malawer SJ, Powell DW (1967) An improved turbidimetric analysis of polyethelene glycol utilizing an emulsifier. Gastroenterology 53: 250–256
Müller-Lissner SA, Sonnenberg A, Blum AL (1981) Does gastric aminopyrine clearance reflect gastric mucosal blood flow or parietal cell function? Gut 22: im Druck
Rudick J, Werther JL, Chapman ML et al. (1971) Mucosal blood flow in canine antral and fundic pouches. Gastroenterology 60: 263–271
Shore PA, Brodie BB, Hogben CA (1975) The gastric secretion of drugs: A pH partition hypothesis. J Pharmacol Exp Ther 119: 361–369
Sonnenberg A, Blum AL (1980) Limitations to measurement of gastric mucosal blood flow by 14C-aminopyrine clearance. In: Fielding LP (ed) Gastro-intestinal mucosal blood flow. Churchill Livingstone, Edinburgh London New York, pp 43–58
Virchow R (1853) Historisches, Kritisches and Positives zur Lehre der Unterleibsaffektionen. Arch Pathol Anatom 5: 281–387
Walsh JH, Richardson CT, Fordtran JS (1975) pH dependence of acid secretion and gastrin release in normal and ulcer patients. J Clin Invest 55: 462–468
Wormsley KG, Grossman MI (1965) Maximal histalog test in control subjects and patients with peptic ulcer. Gut 6: 427–435
Zinner MJ, Kerr JC, Reynolds DG (1975) Adrenergic mechanisms in canine gastric circulation. Am J Physiol 229: 977–982
Zinner MJ, Kerr JC, Reynolds DG (1976) Primate gastric circulation: Effects of catecholamines and adrenergic blockade. Am J Physiol 230: 346–350
Arnold R, 1st M v, Minana I, Koop H (1980) Verhalten der antralen Gastrin (G)- and Somatostatin D)-Zellzahl sowie der immunoreaktiven Gastrin (IRG)- and Somatostatin (IRS)-Konzentration nach selektiv proximaler Vagotomie. Verh Dtsch Ges Inn Med 86: 849–851
Arnold R, Koop H, Creutzfeldt W (1980) Hormones and their role in ulcer disease. In: Holtermüller KH, Malagelada JR (eds) Advances in ulcer disease. Excerpta Medica, Amsterdam Oxford Princeton, pp 207–224
Berson SA, Yalow RS (1972) Radioimmunoassay in gastroenterology. Gastroenterology 62: 1061–1084
Cowley DJ, Dymock IW, Boyes BE, Wilson RY, Stagg BH, Lewin MR, Polak JM, Pearse AGE (1973) Zollinger Ellison syndrome type I. Clinical and pathological correlations in a case. Gut 14: 25–29
Creutzfeldt W, Arnold R, Creutzfeldt C, Track NS (1975) Pathomorphologic, biochemical, and diagnostic aspects of gastrinomas ( Zollinger Ellison syndrome ). Hum Pathol 6: 47–76
DiMagno EP, Go VLW (1974) Malabsorption secondary to antral gastrin cell hyperplasia. Mayo Clin Proc 49: 727–730
Ganguli PC, Polak JM, Pearse AGE, Elder JB, Hegarty M (1974) Antral-gastrin-cell hyperplasia in peptic ulcer disease. Lancet 1: 583–586
Hansky J (1974) Antral-gastrin-cell hyperplasia in peptic ulcer disease (letter). Lancet 1: 1344
Isenberg JI, Walsh JH, Grossman MI (1973) Zollinger-Ellison Syndrome. Gastroenterology 65: 140–165
Lamers CBH, Ruland CM, Joosten HJM, Verkooyen HCM, Tongeren JHM van, Rehfeld JF (1978) Hypergastrinemia of antral origin in duodenal ulcer. Am J Dig Dis 23: 998–1002
Lamers CBH, Tongeren JHM van (1977) Comparative study of the value of the calcium, secretin and meal stimulated increase in serum gastrin to the diagnosis of the Zollinger-Ellison syndrome. Gut 18: 128–134
McGuigan JE, Wolfe MM (1980) Secretin injection test in the diagnosis of gastrinoma. Gastroenterology 79: 1324–1331
Polak JM, Stagg B, Pearse AGE (1972) Two types of Zollinger Ellison syndrome: Immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states. Gut 13: 501–512
Russell RCG, Bloom SR, Davies WA, Polak JM, Reed PI (1975) Hypergastrinemio in a peptic ulcer patient with antral gastrin cell hyperplasia. Br Med J 4: 441
Straus E, Yalow RS (1975) Differential diagnosis of hypergastrinemia. In: Thompson JC (ed) Gastrointestinal hormones. University of Texas Press, Austin, pp 99–113
Austen FK (1979) Biologic implications of the structural and functional characteristics of the chemical mediators of immediate-type hypersensitivity. In: The Harvey lectures, vol 73. Academic Press, New York, p 93
Ehinger B, Owman C, Sporrong B (1968) Histochemical demonstration of histamine in paraffine sections by a fluorescance method. Biochem Pharmacol 17: 1977
Lichtenstein LM (1975) The mechanism of basophile histamine release induced by antigen and by the calcium ionophore A 23187. J Immunol 144: 1692
Lorenz W, Reimann H-J, Barth H, Kusche J, Meyer R, Doenicke A, Hutzel M (1972) A sensitive and specific method for the determination of histamine in human whole blood and plasma. Hoppe Seylers Z Physiol Chem 353: 911
Reimann H-J, Lorenz W, Fischer M, Froelich R, Meyer H-J, Schmal A (1977) Histamine and acute haemorrhagic lesions in rat gastric mucosa; Prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro. Agents Actions 7: 69
Reimann H-J, Swoboda K, Wendt P, Blümel G, Schmidt U, Rakette S, Ultsch B (1980) Die Wirkung des HDC-Blockers (+)-Catechin auf die menschliche Magenschleimhaut bei akuten und chronischen Erkrankungen. Verh Dtsch Ges Inn Med 86: 859–864
Ring J (1978) RIST, BRIST, RAST. Zur Serodiagnostik der allergischen Sofortreaktion. Dtsch Med Wochenschr 103: 365
Werner M (1960) Der intestinale Expositionstest. Internist 1: 202
Werner M, Ruppert V (1979) Praktische Allergiediagnostik. Thieme, Stuttgart
Becker H, Ruoff H-J (1979) Pentagastrin activation of adenyl-cyclase in human gastric biopsy specimens. Experientia 35: 781
Jacobsen ED, Thompson WJ (1976) Cyclic AMP and gastric secretion: the illusive second messenger. Adv Cyclic Nucleotide Res 7: 199
Miederer SE (1977) Die Histotopographie der Magenschleimhaut. Monographie. Thieme, Stuttgart
Ruoff H-J, Painz B, Becker M, Rack M, Sewing K-F, Malchow H (1979) Adenylate cyclase in human gastric mucosa: its activation by histamine in morphologically different biopsy specimens. Klin Wochenschr 57: 725
Simon B, Czygen P, Fröhlich W, Kather H (1977) Topographical studies on histamine and adrenaline sensitive adenylate cyclases in gastric and duodenal mucosa of human beings. Digestion 16: 185
Simon B, Kather H, Kommerell B (1978) Effects of prostaglandins and their methylated analogues upon human adenylate cyclase in the upper gastrointestinal tract. Digestion 17: 547
Soll AH (1979) Hormonal control of parietal cell function. World J Surg 3: 441
Andersson S, Grossman MI (1965) Profile of pH, pressure and potential difference at gastro-duodenal junction in man. Gastroenterology 49: 364
Cohen MM, Cheung GI, Lyster DM (1980) Prevention of aspirin-induced faecal blood loss by prostaglandin E2. Gut 21: 602
Johannson C, Kollberg B, Nordemar R, Bergstrom S (1979) Mucosal cytoprotection by prostaglandin E2. Lancet 1: 317
Müller P, Fischer N, Kather H, Simon B (1981) Prevention of aspirin-induced drop in gastric PD with 16,16-dimethyl-Prostaglandin E2. Lancet 1: 333–334
Müller P, Fischer N, Kather H, Simon B (1981) The cytoprotective effect of 16,16-dimethyl-prostaglandin E2 on bile salt induced damage to the human stomach. Br J Clin Pharmacol (in press)
Robert A, Nezamis JE, Lancaster C, Hanchar AJ (1979) Cytoprotection by prostaglandins in rats: prevention of gastric necrosis produced by alcohol, HCI, NaOH and thermal injury. Gastroenterology 77: 433
Robert A (1967) Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins. In: Samuelsson B, Paoletti R (eds) Advances in prostaglandin and thromboxane research. Raven Press, New York, pp 507–520
Robert A, Nezamis JE, Lancaster C, Hanchar AJ (1979) Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis by alcohol, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 77: 433–443
Miller TA, Jacobson ED (1979) Gastrointestinal cytoprotection by prostaglandins. Gut 20: 75–87
Johansson C, Kollberg B, Nordemar R, Samuelsson K, Bergström S (1980) Protective effect of prostaglandin E2 in the gastrointestinal tract during indomethacin treatment of rheumatic disease. Gastroenterology 78: 479–483
Cohen MM (1978) Mucosal cytoprotection by prostaglandin E2. Lancet 2: 1253–1254
Fung WP, Karim SMM, Tye CY (1974) Effect of 15(R)15 methyl prostaglandin E2 methylester on healing of gastric ulcers. Lancet 2: 10–12
Fung PW, Karim SMM (1976) Effect of prostaglandin E2 on the healing of gastric ulcer: a double-blind endoscopie trial. Aust NZ J Med 6: 121–122
Rybicka J, Gibinski K (1978) Methyl-prostaglandin analogues for healing of gastro-duodenal ulcers. Scand J Gastroenterol 13: 155–159
Bennett A, Stamford IF, Unger WG (1973) Prostaglandin E2 and gastric acid secretion in man. J Physiol 229: 349–360
Peskar BM, Seyberth H, Peskar BA (1980) Synthesis and metabolism of prostaglandins by human gastric mucosa. In: Samuelsson B, Paoletti R (eds) Advances in prostaglandin and thromboxane research, vol 8. Raven Press, New York, pp 1511–1514
Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (New Biol) 231: 232–235
Peskar BM (1977) On the synthesis of prostaglandins by human gastric mucosa and its modification by drugs. Biochim Biophys Acta 487: 307–314
Flower RJ, Vane JR (1972) Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature 240: 410
Woodbury DM, Fingl E (1975) Analgesic-antipytetics, anti-inflammatory agents and drugs employed in the therapy of gout. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, vol 5. MacMillan Publ. Co., New York, pp 325–358
Bustad LK, McClelland RK (1966) Swine in biomedical research. US Atomic Energy Commission and Battelle Memorial Institute, Frayne, Seattle
Muggenburg BA, McNutt SH, Kowalczyk T (1964) Pathology of gastric ulcers in swine. Am J Vet Res 25: 1354–1365
Rainsford KD (1978) Gastric mucosal ulceration induced in pigs by tablets but not suspensions or solutions of aspirin. J Pharm Pharmacol 30: 129–131
Rainsford KD, Peskar BM (1979) Relationship between gastric ulceration and mucosal prostaglandin concentrations following chronic oral administration of aspirin preparations to pigs. In: Brune K, Baggiolini M (eds) Arachidonic acid metabolism in inflammation and thrombosis. Agents Actions [Suppl] 4: 293–297
Jaffe BM, Behrman HR, Parker CW (1973) Radioimmunoassay measurement of prostaglandin E, A and F in human plasma. J Clin Invest 52: 398–504
Peskar BA, Anhut K, Kröner EE, Peskar BM (1978) Development, specificity and some applications of radioimmunoassays for prostaglandins and related compounds. In: Tillement JP (ed) Advances in pharmacology and therapeutics, vol 7. Pergamon Press, Oxford New York, pp 275–386
Peskar BA, Steffens Ch, Peskar BM (1979) Radioimmunoassay of 6-keto-PGFia in biological material. In: Albertini A, Daprada M, Peskar BA (eds) Radioimmunoassay of drugs and hormones. Elsevier-North Holland Biomed. Press, Amsterdam New York Oxford, pp 239–250
Rainsford KD, Peskar BM, Brune K (1981) Relationship between inhibition of prostaglandin production and gastric mucosal damage induced by anti-inflammatory drugs may depend on type of drugs and species. J Pharm Pharmacol 33: 127–128
Whittle BRA, Higgs GA, Eakins KE, Moncada S, Vane JR (1980) Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa. Nature 284: 271–273
Flower RJ, Vane JR (1974) Some pharmacologic and biochemical aspects of prostaglandin biosynthesis and its inhibition. In: Robinson HJ, Vane JR (eds) Prostaglandin synthetase inhibitors. Raven Press, New York, pp 9–18
Brune K, Gubler H, Schweitzer A (1979) Autoradiographic methods for the evaluation of ulcerogenic effects of anti-inflammatory drugs. Pharmacol Ther [B] 5: 199–207
Auer IO et. al. (1979) Gut 20: 261–268
Beck JD et al. (1980) Am J Hematol 8: 185–189
Biberfeld G et al. (1979) Arthritis Rheum 22: 978–982
Bird AG, Britton MD (1976) Gastroenterology 71: 926–932
Cobleigh MA et al. (1980) J Natl Cancer Inst 64: 1041–1045
Dopp AC et al. (1980) Gastroenterology 79: 276–282
Hayward AR et al. (1978) J Immunol 121: 1–5
Meyers S et al. (1976) Gut 17: 911–915
Moretta L et al. (1977) Eur J Immunol 7: 696–700
Pichler WJ et al. (1978) J Immunol 121: 1540–1548
Sachar DB et al. (1976) Ann NY Acad Sci 278: 565–573
Strickland RG et al. (1974) Gastroenterology 67: 569–577
Thayer WR et al. (1976) Gastroenterology 71: 379–384
Victorino, Hodgson (1980) Clin Exp Immunol 14: 156–165
Gupta S, et al. (1979) Cell Immunol 44: 242–251
Gupta S, Good RA (1977) Clin Exp Immunol 30: 222–228
Gupta, S, Good, RA (1978) Clin Immunol Immunopathol 11: 292–302
Gupta Set al. (1979) Clin Immunol Immunopathol 14: 86–95
Gupta Set al. (1979) Clin Exp Immunol 38: 342–347
Gupta S, Safai B, Good RA (1979) Cell Immunol 44: 242–251
Bernier JJ, Florent CH, Desmazures CH, Aymes CH, L’Hirondel CH (1978) Diagnosis of protein-losing enteropathy by gastrointestinal clearance of alpha -antitrypsin. Lancet 2: 763–764
Best W, Becktel JM, Singleton JM, Kern K (1978) Development of a Crohn’s disease activity index. National Cooperative Crohn’s disease study. Gastroenterology 70: 439
Crossley JR, Elliot RB (1977) Simple method for diagnosing protein-losing enteropathies. Br Med J 1: 428–429
Heaney MR, Fields J, Carter RA, Thompson RA, Asquith P (1979) Is fecal alphas-antitrypsin excretion a reliable screening test for protein-losing enteropathy? Lancet 2: 1161–1162
Keaney NP, Kelleher J (1980) Fecal excretion of alphas-antitrypsin in protein-losing enteropathy. Lancet 1: 242
Allan R, Cooke WT (1977) Evaluation of metronidazole in the management of Crohn’s disease. Gut 18: A422
Ammann RW, Müller-Schoop J, Knoblauch M (1978) Therapie des Morbus Crohn im akuten Schub mit Ornidazol ( Tiberal ). Schweiz Med Wochenschr 108: 1075
Beard M, Kenneth L, O’Fallon W, Kurland L, Dockerty M (1979) Lack of evidence for cancer due to use of metronidazole. N Engl J Med 301: 519
Beard C (1980) Cancer after Metronidazole. N Engl J Med 302: 520
Bernstein LH, Frank MS, Brandt LJ, Boley SJ (1980) Healing of perineal Crohn’s disease with metronidazole. Gastroenterology 79: 357
Best WR, Becktel JM, Singleton JW, Kern F (1976) National Cooperative Crohn’s Disease Study. Development of a Crohn’s disease activity index. Gastroenterology 70: 439
Blichfeldt P, Blomhoff JP, Myhre E, Gjone E (1978) Metronidazole in Crohn’s disease, a double blind cross-over clinical trial. Scand J Gastroenterol 13: 123
Davies PS, Rhodes J, Heatley RV, Owan E (1977) Metronidazole in the treatment of chronic proctitis: a controlled trial. Gut 18: 680
Friedman GD (1980) Cancer after metronidazole. N Engl J Med 302: 519
Goldmann P (1980) Metronidazole. N Engl J Med 303: 1212
Hartley-Asp B (1979) Mutagenicity of metronidazole. Lancet 1: 275
Järnerot G, Ursing B, Alm T, Barany F, Bergelin I, Ganrot-Norlin K, Krause U, Krook A, Rosen A (1981) Treatment of active Crohn’s disease with metronidazole or sulphasalazine. A preliminary report of a double blind controlled trial (CCDSS) (in press)
Kagnoff MF (1978) On the etiology of Crohn’s disease. Gastroenterology 75: 526
Kasper H, Sommer H, Kühn HA (1979) Therapy of Crohn’s disease with metronidazole An uncontrolled trial. Acta Hepatogastroenterol (Stuttg) 26: 217
Legator MS, Connor RH, Stoeckel M (1975) Detection of mutagenic activity of metronidazole and niridazole in body fluids of humans and mice. Science 189: 1118
Mayberry J, Rhodes J, Matthews N, Wensinck F (1981) Serum antibodies to anaerobic coccoid rods in patients with Crohn’s disease or ulcerative colitis and in medical and nursing staff. Br Med J 282: 108
Mitelman F, Hartley-Asp B, Ursing B (1976) Chromosome aberrations and metronidazole. Lancet 2: 802
Roe JE (1979) A critical appraisal of the toxicology of metronidazole. In: Philipps J, Collier J (eds) Metronidazole (Royal Society of Medicine. Internat. Congress and Symposium, Series no 18 ). Academic Press, London, p 215
Rustia M, Shubik P (1972) Induction of lung tumors and malignant lymphomas in mice by metronidazole. J Natl Cancer Inst 48: 721
Rustia M, Shubik P (1979) Experimental induction of hepatomas, mammary tumors and other tumors with metronidazole in non inbred SAS: MRC (WI) BR rats. J Natl Cancer Inst 63: 863 —21. Sachar DB, Auslander MO, Walfish JS (1980) Aetiological theories of inflammatory bowel disease. Clin Gastroenterol 9: 231
Summer RW, Switz DM, Sessions JT, Jr, Becktel JM, Best WR, Kern F, Jr, Singleton JW (1979) National Cooperative Crohn’s Disease Study. Results of drug treatment. Gastroenterology 77: 847
Ursing B, Kamme C (1975) Metronidazole for Crohn’s disease. Lancet 1: 775
Winship DH, Summers RW, Singleton JW, Best WR, Becktel JM, Fink LF, Kern F, Jr (1979) National Cooperative Crohn’s Disease Study. Study design and conduct of the study. Gastroenterology 77: 829
Arvanitakis C (1979) Abnormalities of jejunal mucosal enzymes in ulcerative colitis and Crohn’s disease. Digestion 19: 259–266
Dunne WT, Cooke WT, Allan RN (1977) Enzymatic and morphometric evidence for Crohn’s disease as a diffuse lesion of the gastrointestinal tract. Gut 18: 290–294
Ferguson A, Logan RF, McDonald TT (1980) Increased mucosal damage during parasite infection in mice fed an elemental diet. Gut 21: 37–43
Gutschmidt S (1981)“In situ” determinations of apparent Km and Vmax of brush border disaccharidases along the villi of normal human jejuna] biopsy specimens. A quantitative histochemical study. Histochemistry (in press)
Gutschmidt S, Riecken EO (1981) Peptidase activities in different segments of rat small intestine. Gastroentérol Clin Biol (in press)
Gutschmidt S, Lorenz-Meyer H, Riecken EO, Menge H (1978) Mikrodensitometrische Untersuchungen zur Charakterisierung von Enzymaktivitäten am Gewebsschnitt mittels enzymhistochemischer Farbreaktionen. Acta Histochem (Jena) [Suppl] 20: 249–259
Gutschmidt S, Kaul W, Riecken EO (1979) A quantitative histochemical technique for the characterization of a-glucosidases in the brush-border membrane of rat jejunum. Histochemistry 63: 81–101
Kimura T, Shiosaka S, Yoshida A (1978) Effect of dietary amino acids on jejunal sucrase and Leucinaminopeptidase activities in rats. J Nutr 108: 1099–1103
Lehnert S (1979) Changes in growth kinetics of jejunal epithelium in mice maintained on an elemental diet. Cell Tissue Kinet 12: 239–248
Lorenz-Meyer H, Fimmel C, Teutenberg M (1980) Der Effekt der Elementardiät auf Morphologie und Funktion der Dünndarmschleimhaut nach Langzeitexposition. Aktuel Ernähr Klin Prax 5: 74–80
Miller JM, Valbuena RM, Remigo MR (1978) Protection by an elemental diet against the toxic intestinal changes of 5-fluorouracil in rats. J Abdom Surg 20: 162–165
Mohiuddin M, Kramer S (1978) Therapeutic effect of an elemental diet on proline absorption across the irradiated rat small intestine. Radiat Res 75: 660–663
Morin CL, Ling V, Bourassa D (1980) Small intestinal and colonic changes induced by a chemically defined diet. Dig Dis Sci 25: 123–128
Nelson LM, Carmichael HA, Russell RI, Lee FD (1978) Small-intestinal changes induced by an elemental diet ( Vivionex) in normal rats. Clin Sci Mol Med 55: 509–511
Prizont R, Hersh T, Floch MH (1970) Jejunal bacterial flora in chronic small bowel disease. I. Celiac disease. II. Regional enteritis. Am J Clin Nutr 23: 1602–1607
Riecken EO, Sahlfeld M, Lorenz-Meyer H (1976) Quantitative Untersuchungen zur dreidimensionalen Struktur der Dünndarmschleimhaut bei Gesunden und Patienten mit einheimischer Sprue. Dtsch Med Wochenschr 101: 51–53
Riecken EO, Zennek A, Lay A, Menge H (1979) Quantitative study of mucosal structure, enzyme activities and phenylalanine accumulation in jejunal biopsies of patients with early and late onset diabetes. Gut 20: 1001–1007
Rosenzweig NS (1975) Diet and intestinal enzyme adaptation: implications for gastrointestinal disorders. Am J Clin Nutr 28: 648–655
Russell RI, Atherton ST, Nelson LM, Robertson E, Lee FD (1979) Effect of an elemental diet ( Vivonex) on the absorption abnormalities and histological appearances of the jejunum in untreated adult coeliac disease. Digestion 19: 335–339
Steinhardt HJ, Hacker HW, Hoffmann R, Malchow H (1979) Absorption vollresorbierbarer Diäten im Dünndarm. Ein Vergleich von Peptid-, Aminosäure-und Formeldiäten. Z Gastroenterol 17: 597–598
Vidon N, Hecketsweiler P, Butel J, Bernier JJ (1978) Effect of continuous jejunal perfusion of elemental and complex nutritional solutions on pancreatic enzyme secretion in human subjects. Gut 19: 194–198
Weiner R, Schmoz G, Hartig W, Matkowitz R, Conradi G (1980) Enterale Resorption unter oral bilanzierter synthetischer Diät (Berlamin). Klinisch experimentelle Untersuchungen mit dem modifizierten D-Xylose-Resorptionstest. Zentralbi Chir 105: 121–127
Young EA, Cioletti LA, Winborn WB, Traylor JB, Weser E (1980) Comparative study of nutritional adaptation to defined formula diets in rats. Am J Clin Nutr 33: 2106–2118
Garrod AE (1909) Inborn erros of metabolism. Univ. Press, Oxford
Weiser MM, Douglas AP (1976) An alternative mechanism for gluten toxicity in coeliac disease. Lancet 1: 567
Douglas A, Peters TJ (1970) Peptide hydrolase activity of human intestinal mucosa in adult coeliac disease. Gut 11: 15
Asquith P, Thompson RA, Cooke WT (1969) Serum immunglobulins in adult celiac disease. Lancet 2: 129
Katz J, Kantor FS, Hershovic T (1968) Intestinal antibodies to wheat fractions in celiac disease. Ann Intern Med 69: 1149
Falchuk ZM, Rogentine GN, Strober W (1972) Predominance of histocompatibility antigen HL-A8 in patients with glutensitive enteropathy. J Clin Invest 51: 1602
Pena AS, Leeuwen AV, Hooff JP v, Rood JJ v (1976) HLA-DW3 associated with coeliac disease. Lancet 506
Betuel H, Gebuhrer L, Descos L, Bertrand J, Freycon F, Lepetit JC (1980) Coeliac disease and its association with HLA makers. Los Angeles
Falchuk ZM, Nelson DL, Katz AJ, Bernardin JE, Kasadra DD (1980) Gluten-sensitive enteropathy. Influence of histocompatibility type on gluten sensitivy in vitro. J Clin Invest 66: 227
Strominger JL, Mann DL, Parham P, Robb R, Springer T, Terhorst C (1977) Structur of HL-AA and B antigens isolated from cultured human lymphocytes. Cold Spring Harbor Symp Quant Biol 41: 323
Trier JS, Falchuk ZM, Carey MC, Schreiber DS (1978) Celiac sprue and refractory sprue. Gastroenterology 75: 307
Albert E, Harms K, Bertele R, Andreas A, McNicholas A, Kuntz B, Scholz S, Schießl B, Wetzmüller H, Reissinger P, Weeser-Krell Ch (1978) B-cell alloantigens in coeliac disease. In: Perspectives in coeliac disease. Baltimore, p 123
Battle WM, Rubin MR, Cohen S, Snape WJ (1979) Gastrointestinal-motility dysfunction in amyloidosis. N Engl J Med 301: 24–25
Gilat T, Spiro HM (1968) Amyloidosis and the gut. Am J Dig Dis 13: 619–633
Gilat T, Revach M, Sohar E (1969) Deposition of amyloid in the gastrointestinal tract. Gut 10: 98–104
Missmahl HP, Gafni J (1964) Peri-collagen and peri-reticular amyloidosis their differentiation by polarization microscopy. Pathol Microbiol 27: 826–832
Rubenstein AE, Yahr MD, Mytilineou C, Bajaj K (1978) Peripheral catecholamine depletion in amyloid autonomic neuropathy. Mt Sinai J Med NY 45: 782–789
Schmidt H, Frühmorgen P, Riemann JF, Becker V (1981) Mucosal sugillations in the colon in secondary amyloidosis. Endoscopy (in press)
Schmidt H, Riemann JF (1981) Die Amyloidose des Magen-Darm-Traktes. Leber Magen Darm (im Druck )
Sohar E, Merker H-J, Missmahl H-P, Gafni J, Heller H (1967) Electron-microscope observations on peri-reticulin and pericollagen amyloidosis in rectal biopsies. J Pathol 94: 89–93
Beretta KR, Güller R, Singeisen M, Stalder GA (1978) Okkultes Blut im Stuhl eine prospektive Studie zum Vergleich von Haemoccult und Fecatest. Schweiz Med Wochenschr 108: 1905–1907
Brault J, Favre H (1979) Evaluation en pratique hospitalière du fecatest, un nouvel examen de laboratoire pour la recherche de sang occulte dans les selles. Schweiz Med Wochenschr 109: 73–76
Greegor DH (1971) Occult blood testing for detection of asymptomatic colon cancer. Cancer 28: 131–134
Gilbertsen VA, Mchugh R, Schuman L, Williams SE (1980) The earlier detection of colorectal cancers. A Preliminary report of the results of the occult blood study. Cancer 45: 2899–2901
Herzog, P, Holtermüller KH, Preiss J, Fischer J, Ewe K, Michaelis J (1981) Fecal daily blood loss and anatomic location determines the accuracy of testing for occult blood in patients with colonic polyps. Gastroenterology (Abstract) 80 (in press)
Jaffe RM, Kasten B, Young DS, MacLowry JD (1975) False-negative stool occult blood tests caused by ingestion of ascorbic acid (vitamin C). Ann Intern Med 83: 824–826
Miller SF, Knight AR (1977) The early detection of colorectal cancer. Cancer 40: 945–949
Schewe S, Feifel G, Heldwein, Weinzierl M, Wolf W, Bolte HD, Konrad E (1979) Sensitivität des Haemoccult-Tests bei kolorektalen Tumoren. Dtsch Med Wochenschr 104: 253–256
Stroehlein JR, Fairbanks VF, McGill DB, Go VLW (1976) Haemoccult detection of fecal occult blood quantitated by radioassay. Am J Dig Dis 21: 841–844
Winawer SJ, Andrews M, Flehinger B, Sherlock P, Schottenfeld D, Miller G (1980) Progress report on controlled trial of fecal occult blood testing for the detection of colorectal neoplasia. Cancer 45: 2959–2964
Winchester DP, Shull JH, Scanlon EF, Murrell JV, Smeltzer C, Yrba P, Iden M, Streelman DH, Magpayo R, Dow JW, Sylvester J (1981) A mass screening program for colorectal cancer using chemical testing for occult blood in the stool. Cancer 45: 2955–2958
Frimberger E, Frühmorgen P, Kühner W, Ottenjann R (1980) Salizylazosulfapyridin-Klysmen bei akuter linksseitiger Colitis ulcerosa. Ergebnisse einer Doppelblindstudie über ein neues Behandlungsprinzip. Munch Med Wochenschr 36: 1233
Miller B (1977) Wirkung und Nebenwirkungen der Therapie mit Salizylazosulfapyridin. In: Kremer K, Kivelitz H (Hrsg) Celitis ulcerosa. Thieme, Stuttgart, S 71
Moertel CG, Bargen JA (1959) A critical analysis of the use of salicylazosulfapyridin in chronic ulcerative colitis. Ann Intern Med 51: 789
Morrison LM (1953) Medical treatment of chronic ulcerative colitis. JAMA 153: 1580
Möller C, Kiviluoto O, Santavirta S, Holtz A (1978) Local treatment of ulcerative proctitis with salicylazosulphapyridine ( Salazopyrin) enema. Clin Trials J (Lond) 15: 199
Schulz U, Hanke P, Seige K (1973) Über die rektale Wirkung von Salazopyrin bei Colitis ulcerosa im doppelten Blindversuch. Wien Z Inn Med Grenzgeb 54: 185
Serebro H, Kay S, Javett S, Abrahams C (1977) Sulphasalzine rectal enemas: topical method of inducing remission of active ulcerative colitis affecting rectum and descending colon. Br Med J 12: 1264
Svartz N (1968) Treatment of ulcerative colitis with Salazopyrin. Int Surg 50: 421
Watkinson G (1961) Medical management of ulcerative colitis. Br Med J 1: 147
Watkinson G (1968) The medical treatment of ulcerative colitis. Postgrad Med J 44: 696
Watkinson G (1968) Ulcerative colitis. In: Goligher JC et al. (ed) Bailliére, Tindall and Cassell, London, pp 207–208
Kramer W, Buscher H-P, Gerok W, Kurz G (1979) Bile salt binding to serum components. Eur J Biochem 102: 1–9
Cronholm T, Sjövall J (1967) Bile acids in portal blood of rats fed different diets and cholestyramin. Eur J Biochem 2: 375–383
Stiehl A, Czygan P, Kommerell B (1978) Ursodeoxycholic acid versus chenodeoxycholic acid. Comparison of their effects on bile acids and bile lipid composition in patients with cholesterol gallstones. Gastroenterology 75: 1016–1020
Carey MC (1978) Critical tables for calculating the cholesterol saturation in native bile. J Lipid Res 19: 945–955
Corrigan OI, Su CC, Higuchi WI (1980) Mesophase formation during cholesterol dissolution in ursodeoxycholate-lecithin solution: new mechanism for gallstone dissolution in humans. J Pharm Sci 69: 869–870
Igimi H, Carey MC (1980) pH-Solubility relations of chenodeoxycholic and ursodeoxycholic acids: physical-chemical basis for dissimilar solution and membrane phenomena. J Lipid Res 21: 72–90
Stiehl A, Raedsch R, Czygan P, Götz R, Männer CH, Walker S, Kommerell B (1980) Effects of biliary bile acid composition on biliary cholesterol saturation in gallstone patients treated with chenodeoxycholic acid and/or ursodeoxycholic acid. Gastroenterology 79: 1192–1198
Narisawa T, Magaida NE, Weisenburger JH, Wynder EL (1974) Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N-nitro-N-nitrosoguanidine in rats. J Natl Cancer Inst 53: 1093–1097
Craddock VM (1978) Cell proliferation and induction of liver cancer. In: Remmer H, Bolt HM, Bannaschi P, Popper H (eds) Primary liver tumors. MTP Press, Lancaster, pp 377–383
Danzinger RG, Hofman AF, Schoenfield LJ, Thistle JL (1972) Dissolution of cholesterol gallstones by chenodeoxycholic acid. N Engl J Med 289: 1–8
Makino I, Shinozaki K, Yoshino K, Nakagawa S (1975) Dissolution of cholesterol gallstones by ursodeoxycholic acid. Jpn J Gastroenterol 76: 690–691
Banwell JG, Lepot A, Hanke DW, Sigdestad C (1978) Small intestinal epithelial renewall in the syrian hamster exposed to cholera enterotoxin. Gastroenterology 75: 717–722
Takeuchi K, Johnson LR (1979) Pentagastrin protects against stress ulceration in rats. Gastroenterology 76: 327–334
Burton K (1956) A study of the conditions and mechanism of the diphenylamine reaction for the calorimetric estimation of deoxyribonucleic acid. Biochem J 62: 315–323
Binder HJ, Dobbins JW, Racusen LC, Whiting DS (1978) Effect of propranolol on ricinoleic acid-and deoxycholic acid-induced changes of intestinal electrolyte movement and mucosal permeability. Gastroenterology 75: 668–673
Goerg KJ, Nell G, Sprecht W (1978) Correlation between the 51CrEDTA clearance and the secretion of fluid and electrolytes under the influence of deoxycholate ( DC) in the rat colon. Naunyn-Schmiedebergs Arch Pharmacol 302: R1
Mekhjian HS, Philips HS, Hofmann AF (1971) Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man. J Clin Invest 50: 1569–1577
Rummel W (1976) Wirkungen von Gallensäuren und Laxantien auf den mukosalen Transfer. Bull Schweiz Akad Med Wiss 32: 233–250
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Berges, W. et al. (1981). Gastroenterologie. In: Miehlke, K. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 87. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47092-9_15
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