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Verhandlungen der Deutschen Gesellschaft für innere Medizin pp 782–802Cite as

Hämostaseologie

  • Conference paper

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Part of the book series: Verhandlungen der Deutschen Gesellschaft für innere Medizin ((VDGINNERE,volume 87))

Zusammenfassung

In der Pathogenese der sklerotischen Gefäßwandprozesse spielt die Proliferation mesenchymaler Zellen aus Intima, Media und Adventitia eine Schlüsselrolle. Andererseits kommt es dabei durch lokale Endothelläsionen und Gerinnungsaktivierung zur Abscheidung von Mikrothromben, welche inkorporiert und organisiert werden. Es resultiert eine weitere Verdickung der Gefäßwand und somit ein Fortschreiten des arteriosklerotischen Prozesses (Duguid 1946). Gerinnungsaktivierung und Zellproliferation treten also bei der Arteriosklerose parallel zueinander auf. Unsere Untersuchungen galten dem Problem, ob und wie Gerinnung und gesteigerte Vermehrung von Gefäßwandzellen miteinander ursächlich verknüpft sind. Es sollte der Einfluß von Thrombin, Faktor XIII (F XIII), Kallikrein und Fibronectin auf das Proliferationsverhalten von Fibroblasten, Endothelzellen und glatten Muskelzellen analysiert werden. Weitere Untersuchungen galten dem Ziel, eine Vorstellung über die zugrundeliegenden Wirkmechanismen zu erhalten.

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Author information

Authors and Affiliations

  1. Med. Univ.-Klinik, Deutschland

    R. Bernsmeier & H. D. Bruhn

  2. Univ.-Hautklinik, Kiel, Deutschland

    J. Pohl

  3. Abt. für Hämostaseologie des Zentrums für Innere Medizin, Zentrale Abt. des Strahlenzentrums, Univ. und Klin., Deutschland

    J.-C. Bernhard, I. Mahn & G. Müller-Berghaus

  4. Forschungsgruppe für Blutgerinnung und Thrombose, Max-Planck-Gesellschaft Gießen, Deutschland

    J.-C. Bernhard, I. Mahn & G. Müller-Berghaus

  5. Abt. Innere Medizin I und II und Abt. Klirr. Pharmakologie, Med. Univ.-Klinik, Heidelberg, Deutschland

    J. Harenberg, R. Zimmermann, D. Arleth, K. Matthes & E. Weber

  6. Med. Klinik Innenstadt, Univ. München, Deutschland

    W. Schramm & R. Marx

  7. Med. Univ.-Klinik und Patholog. Inst., Univ. Köln, Deutschland

    H. Linker, S. Steigleder, B. Königstein, K. Anschütz, H. D. Reuter, H. E. Schäfer, B. Ruping, W. Waidhas, W. Glöckner, H. Borberg & H. E. Wichmann

Authors
  1. R. Bernsmeier
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  2. H. D. Bruhn
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  3. J. Pohl
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  4. J.-C. Bernhard
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  5. I. Mahn
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  6. G. Müller-Berghaus
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  7. J. Harenberg
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  8. R. Zimmermann
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  9. D. Arleth
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  10. K. Matthes
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  11. E. Weber
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  12. W. Schramm
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  13. R. Marx
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  14. H. Linker
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  15. S. Steigleder
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  16. B. Königstein
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  17. K. Anschütz
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  18. H. D. Reuter
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  19. H. E. Schäfer
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  20. B. Ruping
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  21. W. Waidhas
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  22. W. Glöckner
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  23. H. Borberg
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  24. H. E. Wichmann
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Editor information

K. Miehlke

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© 1981 Springer-Verlag Berlin Heidelberg

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Bernsmeier, R. et al. (1981). Hämostaseologie. In: Miehlke, K. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 87. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47092-9_14

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  • DOI: https://doi.org/10.1007/978-3-642-47092-9_14

  • Publisher Name: J.F. Bergmann-Verlag, Munich

  • Print ISBN: 978-3-8070-0327-6

  • Online ISBN: 978-3-642-47092-9

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