Zusammenfassung
Neben dem antidiuretischen Hormon kommt den renalen Prostaglandinen (PG) wahrscheinlich eine Bedeutung bei der Regulation der renalen Wasserexkretion zu. So finden sich:
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1.
Eine hohe PG-Synthetase-Aktivität in den interstitiellen Zellen [16] und den Sammelrohrepithelien [13] des Nierenmarks.
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2.
Prostaglandin E hemmt die ADH-abhängige Wasserpermeabilitätsänderung an der Krötenblase [12] und im isolierten Sammelrohr [6].
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3.
Eine Hemmung der PG-Synthese steigert das renale Konzentrationsvermögen in vivo [1, 2, 8].
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Glänzer, K., Düsing, R., Kramer, H.J., Appenheimer, M., Vetter, H., Krück, F. (1980). Untersuchungen zur Beziehung von Arginin-Vasopressin, cAMP und Prostaglandin E2 zur renalen Konzentrationsfähigkeit des Menschen. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 86. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47091-2_45
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