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Hypothalamischer und hypophysärer Hypogonadismus des Mannes

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Verhandlungen der Deutschen Gesellschaft für innere Medizin

Part of the book series: Verhandlungen der Deutschen Gesellschaft für innere Medizin ((VDGINNERE,volume 86))

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Zusammenfassung

Unter Hypogonadismus wird eine Störung der endokrinen und/oder exokrinen Hodenfunktion verstanden. Die Ursache für einen Hypogonadismus kann entweder in den Testes selber lokalisiert sein, in den übergeordneten steuernden Organen Hypothalamus und Hypophyse, in den Zielorganen der Androgene oder im Transportsystem für Androgene (Tabelle 1). In den letzten Jahren hat die Forschung gerade auf dem Gebiete der zentralen Steuerung der Hodenfunktion erhebliche Fortschritte gemacht, und es ergeben sich aus den physiologischen Beobachtungen neue Ansätze für Diagnostik und Therapie des Hypogonadismus.

Referat anläßlich der gemeinsamen Sitzung der Deutschen Gesellschaft für innere Medizin und der Deutschen Gesellschaft für Neurologie

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Literatur

  • Axelrod L, Neer RM, Kliman B (1979) Hypogonadism in a male with immunologically active, biologically inactive luteinizing hormone: an exception to a venerable rule. J Clin Endocrinol Metab 48:279–287

    Article  PubMed  CAS  Google Scholar 

  • Beitins IZ, Dufau ML, O’Loughlin K, Catt KJ, McArthur JW (1977) Analysis of biological and immunological activities in the two pools of LH released during constant infusion of luteinizing hormone-releasing hormone (LHRH) in men. J Clin Endocrinol Metab 45:605–608

    Article  PubMed  CAS  Google Scholar 

  • Berquist C., Nillius SJ, Wide L (1979a) Intranasal gonadotropin-releasing hormone agonist as a contraceptive agent. Lancet 2: 215–217

    Article  CAS  Google Scholar 

  • Berquist C., Nillius SJ, Berg T, Skarin G, Wide L (1979b) Inhibitory effects on gonadotrophin secretion and gonadal function in men during chronic treatment with a potent stimulary luteinizing hormone-releasing hormone analogue. Acta Endocrinol (Kbh) 91:601–608

    Google Scholar 

  • Bremner WJ, Paulsen CA (1977) Prolonged intravenous infusions of LH-releasing hormone into normal men. Horm Metab Res 9:13–16

    Article  PubMed  CAS  Google Scholar 

  • Bremner WJ, Fernando NN, Paulsen CA (1977) The effect of luteinizing hormone-releasing hormone in hypogonadotrophic eunuchoidism. Acta Endocrinol (Kbh) 86:1–14

    CAS  Google Scholar 

  • Bowen P, Ferguson-Smith MA, Mosier D, Lee CSN, Butter HG (1965) The Lawrence-Moon-syndrome association with hypogonadotropic hypogonadism and sexchromosome anemploidy. Arch Intern Med 116:598–602

    Article  PubMed  CAS  Google Scholar 

  • Brown GM, Friend WC, Chambers JW (1979) Neuropharmacology of hypothalamic-pituitary regulation. In: Tolis G, Labrie F, Martin JB, Naftolin F (eds) Clinical neuroendocrinology. Raven Press, New York, pp 47–81

    Google Scholar 

  • Cacciari E, Cicognani A, Pirazzoli P, Bernardi F, Zappulla F, Capelli M, Tassinari D, Frejaville E (1979) Treatment of cryptorchidism by intranasal LH-RH. In: Laron Z, Tikva P (eds) Cryptorchidism. Karger, Basel München Paris London New York Sydney, pp 173–179

    Google Scholar 

  • Carmel PW, Araki S, Ferin M (1976) Pituitary stalk portal blood collection in rhesus monkeys evidence for pulsatile release of gonadotropin-releasing hormone (GnRH). Endocrinology 99: 243–248

    Article  PubMed  CAS  Google Scholar 

  • Carter JN, Tyson JE, Tolis G, Van Vliet S, Faiman C., Friesen HG (1978) Prolactin-secreting tumors and hypogonadism in 22 men. N Engl J Med 299: 847–852

    Article  PubMed  CAS  Google Scholar 

  • Chowdhury M, Steinberger A, Steinberger E (1978) Inhibition of de novo synthesis of FSH by the Sertoli cell factor (SCF). Endocrinology 103:644–649

    Article  PubMed  CAS  Google Scholar 

  • Conte FA, Grumbach MM, Kaplan SL, Reiter EO (1980) Correlation of luteinizing hormone-releasing factorinduced luteinizing hormone and follicle-stimulating hormone release from infancy to 19 years with the changing pattern of gonadotropin secretion in agonadal patients: Relation to the restraint of puberty. J Clin Endocrinol Metab 50:163–168

    Article  PubMed  CAS  Google Scholar 

  • Costin G, Kogut MD, Hymann CB, Ortega JA (1979) Endocrine abnormalities in thalassemia major. Am J Dis Child 133:497–502

    PubMed  CAS  Google Scholar 

  • Cunningham GR, Huckins C (1977) An FSH and prolactinsecreting pituitary tumor: Pituitary dynamics and testicular histology. J Clin Endocrinol Metab 44: 248–253

    Article  PubMed  CAS  Google Scholar 

  • Davies TF, Mountjoy CQ, Gomez-Pan A, Watson MJ, Hanker JP, Besser GM, Hall R (1976) A double blind cross over trial of gonadotrophin releasing hormone (LHRH) in sexually impotent men. Clin Endocrinol (Oxf) 5: 601–607

    Article  CAS  Google Scholar 

  • Dym M, Raj HGM, Lin YC, Chemes HE, Kotite NJ, Nayfeh SN, French FS (1979) Is FSH required for maintenance of spermatogenesis in adult rats? J Reprod Fertil [Suppl] 26: 175–182

    CAS  Google Scholar 

  • Franchi F, Luisi M, Kicovic PM (1978) Long-term study of oral testosterone undecanoate in hypogonadal males. Int J Androl 3: 1–5

    Google Scholar 

  • Franchimont P, Demoulin A, Verstraelen-Proyard J, Hazee-Hagelstein MT, Walton JS, Waites GMH (1978) Nature and mechanism of action of inhibin: perspective in regulation of male fertility. Int J Androl [Suppl] 2: 69–80

    Article  CAS  Google Scholar 

  • Franks S, Jacobs HS, Martin N, Nabarro JDN (1978) Hyperprolactinaemia and impotence. Clin Endocrinol (Oxf) 8: 277–287

    Article  CAS  Google Scholar 

  • Frey H, Aakvaag A, Saanum B, Falch J (1979) Bioavailability of oral testosterone undecanoate in males. Eur J Clin Pharmacol 16: 345–349

    Article  PubMed  CAS  Google Scholar 

  • Friend JN, Judge DM, Sherman BM, Santen JR (1976) FSH-secreting pituitary adenomas: stimulation and suppression studies in two patients. J Clin Endocrinol Metab 43: 650–657

    Article  PubMed  CAS  Google Scholar 

  • Gutai JP, Daneman D, Foley TP (1979) Response to pulsatile gonadotropin releasing hormone in hypothalamic hypogonadism. Acta Endocrinol [Suppl] (Kbh) 225: 137

    Google Scholar 

  • Happ J, Neubauer M, Egri A, Demisch K, Schöffling K, Beyer J (1975) GnRH therapy in males with hypogonadotrophic hypogonadism. Horm Metab Res 7: 526

    Article  PubMed  CAS  Google Scholar 

  • Happ J, Kollmann F, Krawehl C., Neubauer M, Krause U, Demisch K, Sandow J, Rechenberg W von, Beyer J (1978) Treatment of cryptorchidism with pernasal gonadotropin-releasing hormone therapy. Fertil Steril 29: 546–551

    PubMed  CAS  Google Scholar 

  • Hodson CA, Simpkins JW, Pass KA, Aylsworth CF, Steger RW, Meites J (1980) Effects of a prolactin secreting pituitary tumor on hypothalamic, gonadotropic and testicular function in male rats. Neuroendocrinology 30: 7–10

    Article  PubMed  CAS  Google Scholar 

  • Hsueh AJ, Dufau ML, Catt KJ (1976) Regulation of luteinizing hormone receptors in testicular interstitial cells by gonadotropin. Biochem Biophys Res Commun 72:1145–1150

    Article  PubMed  CAS  Google Scholar 

  • Illig R, Kollmann F, Borkenstein M, Kuber W, Exner GU, Kellerer K, Lunglmayr L, Prader A (1977) Treatment of cryptorchidism by intranasal synthetic luteinizing-hormone releasing hormone. Lancet 2:518–520

    Article  PubMed  CAS  Google Scholar 

  • Jacobson RI, Seyler LE, Tamorlane WV, Gertner JM, Genel M (1979) Pulsatile subcutaneous nocturnal administration of GnRH by portable infusion pump in hypogonadotropic hypogonadism: initiation of gonadotropin responsiveness. J Clin Endocrinol Metab 49: 652–654

    Article  PubMed  CAS  Google Scholar 

  • Jaramillo CJ, Charro-Salgado AL, Perez-Infante V, Obanza EB, Iglesias FC, Fernandez-Cruz A, Coy D, Schally AV (1978) Clinical studies with D-TRP6-luteinizing hormone-releasing hormone in men with hypogonadotropic hypogonadism. Fertil Steril 30:430–435

    PubMed  CAS  Google Scholar 

  • Johnsen SG (1966) A study of human testicular function by the use of human menopausal gonadotrophin and of human chorionic gonadotrophin in male hypogonadotrophic eunuchoidism and infantilism. Acta Endocrinol (Kbh) 53: 315–341

    CAS  Google Scholar 

  • Judd HL (1979) Biorhythms of gonadotropins and testicular hormone secretion. In: Krieger DT (ed) Endocrine rhythms. Raven Press, New York, pp 299–324

    Google Scholar 

  • Kletzky OA, Costin G, Marrs RP, Bernstein G, March CM, Mishell DR (1979) Gonadotropin insufficiency in patients with thalassemia major. J Clin Endocrinol Metab 48: 901–905

    Article  PubMed  CAS  Google Scholar 

  • Krulich L (1979) Central neurotransmitters and the secretion of prolactin, GH, LH and TSH. In: Edelman IS, Schultz SG (eds) Annual review of physiology. Annual Reviews Inc., Palo Alto, pp 603–615

    Google Scholar 

  • Labrie F, Auclair C., Cusan L, Kelly PA, Pelletier G, Ferland L (1978) Inhibitory effect of LHRH and its agonists on testicular gonadotrophin receptors and spermatogenesis in the rat. Int J Androl [Suppl] 2:1–6

    Google Scholar 

  • Leyendecker G (1979) The pathophysiology of hypothalamic ovarian failure. Eur J Obstet Gynec Reprod Biol 9:175–186

    CAS  Google Scholar 

  • deLorimer AA, Gordan GS, Lowe RC, Carbone JV (1965) Methyltestosterone, related steroids and liver function. Arch Intern Med 116:289–294

    Article  Google Scholar 

  • Lundberg PO, Wide L (1978) Sexual function in males with pituitary tumors. Fertil Steril 29:175–179

    PubMed  CAS  Google Scholar 

  • Marynick SP, Loriaux DL, Sherins RJ, Pita JC, Lipsett MB (1979) Evidence that testosterone can suppress pituitary gonadotropin secretion independently of peripheral aromatization. J Clin Endocrinol Metab 49:396–398

    Article  PubMed  CAS  Google Scholar 

  • Morgner KD, Geisthövel W, Niedergerke U, Mühlen A z v (1974) Hypogonadismus infolge Mangels an Luteotropin-Releasing-Hormon (LHRH) bei Prader-Lab-hart-Willi-Syndrom. Dtsch Med Wochenschr 99:1196–1198

    Article  PubMed  CAS  Google Scholar 

  • Mortimer CH, McNeilly AS, Fisher RA, Murray MAF, Besser GM (1974) Gonadotrophin-releasing hormone therapy in hypogonadal males with hypothalamic or pituitary dysfunction. Br Med J 4: 617–621

    Article  PubMed  CAS  Google Scholar 

  • Naftolin F, Ryan KJ, Davies IJ, Reddy VV, Flores F, Petro Z, Kuhn M, White RJ, Wolin L, Takaoka Y (1975) The formation of estrogens by central neuroendocrine tissues. Recent Prog Horm Res 31: 295–300

    PubMed  CAS  Google Scholar 

  • Nieschlag E, Rohr M, Wombacher H, Overzier C (1971) Leydig-Zell-Funktionstest. Bestimmung des Plasmatestosterons durch kompetitive Proteinbindung vor und nach hCG-Belastung. Klin Wochenschr 49:91–95

    Article  PubMed  CAS  Google Scholar 

  • Nieschlag E, Kley KH, Wiegelmann W, Solbach HG, Krüskemper HL (1973) Lebensalter und endokrine Funktion der Testes des erwachsenen Mannes. Dtsch Med Wochenschr 98:1281–1283

    Article  PubMed  CAS  Google Scholar 

  • Nieschlag E, Mauss J, Coert A, Kicovic P (1975) Plasma androgen levels in men after oral administration of testosterone or testosterone undecanoate. Acta Endocrinol (Kbh) 79: 366–371

    CAS  Google Scholar 

  • Nieschlag E, Cüppers HJ, Wiegelmann W, Wickings EJ (1976) Bioavailability and LH-suppressing effect of different testosterone preparations in normal and hypogonadal men. Horm Res 7:138–142

    Article  PubMed  CAS  Google Scholar 

  • Nieschlag E (1979) Der männliche Hypogonadismus. Internist 20:57–66

    PubMed  CAS  Google Scholar 

  • Pasqualini RQ (1950) Diagnostico de la insuficiencia testicular. Endocrinologia 1:20–27

    Google Scholar 

  • Patritti-Laborde N, Odell WD (1978) Short-loop feedback of luteinizing hormone: dose-response relationships and specificity. Fertil Steril 30:456–460

    PubMed  CAS  Google Scholar 

  • Sandow S, von der Ohe M, Kuhl H (1980) LH-RH and its analogues in contraception. Abstract, p 113, VI. Intern. Congress of Endocrinology, Melbourne/Australien

    Google Scholar 

  • Schill WB (1979) Fortschritte in der pharmakologischen Theapie der Subfertilität beim Mann — eine Übersicht. Andrologia 11:77–107

    Article  PubMed  CAS  Google Scholar 

  • Schneider HPG, Leyendecker G (1980) The normal and dysregulated human menstrual cycle. In: Briggs MH, Corbin A (eds) Adv Steroid Biochem Pharmacol 7: 23–50

    Google Scholar 

  • Schwarzstein L, Aparicio NJ, Turner D, Calamera JC, Mancini R, Schally AV (1975) Use of synthetic luteinizing hormone releasing hormone in treatment of Oligospermic men: a preliminary report. Fertil Steril 26:331–336

    PubMed  CAS  Google Scholar 

  • Schulte-Beerbühl M, Nieschlag E (1980) Comparison of testosterone, dihydrotestosterone, luteinizing hormone, and follicle-stimulating hormone in serum after injection of testosterone enanthate or testosterone cypionate. Fertil Steril 33: 201–203

    PubMed  Google Scholar 

  • Smith R, Donald RA, Espiner EA, Stronach SG, Edwards IA (1979) Normal adults and subjects with hypogonadotropic hypogonadism respond differently to D-Ser(TBU)6-LH-RH-EA10. J Clin Endocrinol Metab 48:167–180

    Article  PubMed  CAS  Google Scholar 

  • Snyder PJ, Rudenstein RS, Gardner DF, Rothman JG (1979) Repetitive infusion of gonadotropin-releasing hormone distinguishes hypothalamic from pituitary hypogonadism. J Clin Endocrinol Metab 48:864–868

    Article  PubMed  CAS  Google Scholar 

  • Steinberger A, Steinberger E (1976) Secretion of an FSH-inhibiting factor by cultured Sertoli cells. Endocrinology 99: 918–922

    Article  PubMed  CAS  Google Scholar 

  • Tharandt L, Schulte H, Benker G, Hackenberg K, Reinwein D (1977) Treatment of isolated gonadotropin deficiency in men with synthetic LH-RH and a more potent analogue of LH-RH. Neuroendocrinology 24:195–207

    Article  PubMed  CAS  Google Scholar 

  • Trockel U, Nieschlag E, Krüskemper HL (1980) Die differentialdiagnostische Bedeutung des Leydig-Zell-Stimulationstestes. Med Welt 31: 27–31

    PubMed  CAS  Google Scholar 

  • Vigersky RA, Easley RB, Loriaux DL (1976) Effect of fluoxymesterone on the pituitary-gonadal axis: the role of testosterone estradiol-binding globulin. J Clin Endocrinol Metab 43:1–5

    Article  PubMed  CAS  Google Scholar 

  • Westaby D, Paradinas FJ, Ogle SJ, Randell JB, Murray-Lyon IM (1977) Liver damage from long-term methyltestosterone. Lancet 2:261–272

    Article  Google Scholar 

  • Wickings EJ, Usadel KH, Dathe G, Nieschlag E (1980) The role of follicle stimulating hormone in testicular function of the mature rhesus monkey. Acta Endocrinol (Kbh) (in press)

    Google Scholar 

  • Wiegelmann W, Solbach HG, Kley HK, Nieschlag E, Rudorff KH, Krüskemper HL (1976) Effect of a new LH-RH analogue (D-Ser(TBU)6-EA10-LH-RH) on gonadotrophin and gonadal steroid secretion in men. Horm Res 7:1–10

    Article  PubMed  CAS  Google Scholar 

  • Wise PM, Rance N, Barr GD, Barraclough C (1979) Further evidence that luteinizing hormone-releasing hormone also is follicle-stimulating hormone-releasing hormone. Endocrinology 104: 940–945

    Article  PubMed  CAS  Google Scholar 

  • Zarate A, Valdés-Vallina F, González A, Perez-Ubierna C., Canales ES, Schally AV (1973) Therapeutic effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. Fertil Steril 24:485–486

    PubMed  CAS  Google Scholar 

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  1. Abt. für Experimentelle Endokrinologie, Univ.-Frauenklinik Münster, Deutschland

    E. Nieschlag & G. Brabant

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  1. E. Nieschlag
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  2. G. Brabant
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  1. Kliniken der Landeshauptstadt Wiesbaden, D-6200, Wiesbaden, Deutschland

    Bernhard Schlegel

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Nieschlag, E., Brabant, G. (1980). Hypothalamischer und hypophysärer Hypogonadismus des Mannes. In: Schlegel, B. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 86. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47091-2_12

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  • DOI: https://doi.org/10.1007/978-3-642-47091-2_12

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