Skip to main content
SpringerLink
Log in

Das morphologische Substrat der Leberinsuffizienz

  • Conference paper
FÜnfundsiebzigster Kongress

Part of the book series: Verhandlungen der Deutschen Gesellschaft Für Innere Medizin ((VDGINNERE,volume 75))

  • 8 Accesses

Zusammenfassung

Leberinsuffizienz kann willkürlich und nicht scharf in zwei Formen unterteilt werden. Die erste ist eine relative milde Leberfunktionsschädigung, klinisch charakterisiert durch Müdigkeit uud Appetitlosigkeit. Die Leberfunktionsproben sind abnormal. Die andere Form ist die schwere hepatische Insuffizienz, die klinisch hauptsächlich mit cerebralen Erscheinungen wie Encephalopathie, Präkoma und Koma [1] einhergeht und bei der hamorrhagische Diathese häufig ist. Das Krankheitsbild hängt nicht nur von den strukturellen und funktionalen Anomalitäten der Leberzelle ab, sondern auch von der speziellen Sensitivität des Gehirns. Es ist unter diesen Umständen besonders arzneiempfindlich und Niereninsuffizienz [2, 3] kann auch eine Rolle spielen.

Original work referred to has been conducted under U.S. Public Health Service Grant AM 03846 and U.S. Army Contract No. Da 49-193-MD-2822

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 49.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Sherlock, S.: Diseases of the liver and biliary system, 4th ed., p. 103. Oxford: Blackwell Scientific Publications 1968.

    Google Scholar 

  2. Papper, S., Belsky, J. L., and Bleiffer, K. H.: Renal failure in Laennec’s cirrhosis of the liver. I. Description of clinical and laboratory features. Ann. intern. Med. 51, 759 (1959).

    Article  PubMed  CAS  Google Scholar 

  3. Baldus, W. P., and Summerskill, W. H. J.: Kidney in hepatic disease. Postgrad. Med. 41, 103 (1967).

    PubMed  CAS  Google Scholar 

  4. Wepler, W., u. Wildhirt, E.: Klinische Histopathologie der Leber. Stuttgart: Thieme 1968.

    Google Scholar 

  5. Bianchi, L.: Punktat-Morphologie und Differential Diagnose der Hepatitis. Bern: Huber Verlag 1967.

    Google Scholar 

  6. Popper, H., Steigmann, F., and Szanto, P. B.: Quantitative correlation of morphologic liver changes and clinical tests. Amer. J. clin. Path. 19, 710 (1949).

    CAS  Google Scholar 

  7. Hübner, G.: Die pathischen Reaktionen des Lebergewebes. Eine elektronenmikroskopische Studie. (Veröffentlichungen aus der morphologischen Pathologie, H. 78) Stuttgart: Fischer 1968.

    Google Scholar 

  8. Popper, H.: Organelle pathology of the liver. Trans. Coll. Phycns. (Philad.) 34, 127 (1967).

    CAS  Google Scholar 

  9. Lucké, B.: The pathology of fatal hepatitis. Amer. J. Path. 20, 471 (1944).

    PubMed  Google Scholar 

  10. Lucké, B., and Mallory, T.: The fulminant form of epidemic hepatitis. Amer. J. Path. 22, 867 (1946).

    Google Scholar 

  11. Ritt, D. J., Whelan, G., Werner, D. J., Eigenbrodt, E. H., Schenker, S., and Combes, B.: Acute hepatic necrosis with stupor or coma. An analysis of thirty-one patients. Medicine (Baltimore) 48, 151 (1969).

    Article  CAS  Google Scholar 

  12. Kalk, H.: Hepatitis und posthepatitische Leberkrankheiten. Verh. dtsch. Ges. inn. Med. 63, 177 (1957).

    Google Scholar 

  13. Trey, C., Lipworth, L., Chalmers, T. C, Davidson, C. S., Gottlieb, L. S., Popper, H., and Saunders, S. J.: Fulminant hepatic failure. Presumable contribution of Halothane. New Engl. J. Med. 279, 798 (1968).

    Article  PubMed  CAS  Google Scholar 

  14. Trey, C., Burns, D. G., and Saunders, S. J.: Treatment of hepatic coma by exchange blood transfusion. New Engl. J. Med. 274, 473 (1966).

    Article  PubMed  CAS  Google Scholar 

  15. Berger, R. L., Liversage, R. M., Chalmers, R. C, Graham, J. H., McGoldrick, D. M., and Stohlman, F.: Exchange transfusions in treatment of fulminant hepatitis. New Engl. J. Med. 274, 497 (1966).

    Article  PubMed  CAS  Google Scholar 

  16. Eiseman, B., Liem, D. S., and Raffucci, F.: Heterologous liver perfusion in treatment of hepatic failure. Ann. Surg. 162, 329 (1965).

    Article  PubMed  CAS  Google Scholar 

  17. Popper, H. Rubin, E., Gardiol, D., Schaffner, F., and Paronetto, F.: Drug-induced liver disease. A penalty for progress. Arch. intern. Med. 115, 128 (1965).

    Article  PubMed  CAS  Google Scholar 

  18. Klion, F. M., Schaffner, F., and Popper, H.: Hepatitis following administration of Halothane anesthesia. Ann. intern. Med. (in press).

    Google Scholar 

  19. Subcommittee on the National Halothane Study. Possible association between Halothane anesthesia and postoperative hepatic necrosis. J. Amer. med. Ass. 197, 775 (1966).

    Article  Google Scholar 

  20. Rodriguez, M., Paronetto, F., Schaffner, F., and Popper, H.: Antimitochondrial antibodies in jaundice following drug administration. J. Amer. med. Ass. 208, 648 (1969).

    Article  Google Scholar 

  21. Clain, D., Freston, J.W., Kreel, S., and Sherlock, S.: Clinical diagnosis of the Budd-Chiari syndrome. Quart.

    Google Scholar 

  22. Morrow, R. H., Smetana, H. F., Sai, F. T., and Edgecomb, J. H.: Unusual features of viral hepatitis in Accra, Ghana. Ann. intern. Med. 68, 1250 (1968).

    Article  PubMed  Google Scholar 

  23. Beckett, A. G., Livingstone, A. V., and Hill, K. R.: Acute alcoholic hepatitis. Brit. med. J. 2, 1113 (1961).

    Article  PubMed  CAS  Google Scholar 

  24. Edmondson, H. A., Peters, R. L., Reynolds, T. B., and Kuzma, O. T.: Sclerosing hyaline necrosis of the liver in the chronic alcoholic: A recognizable clinical syndrome. Ann. intern. Med. 59, 646 (1963).

    Article  PubMed  CAS  Google Scholar 

  25. Popper, H., and Szanto, P. B.: Fatty liver with hepatic failure in alcoholics. J. Mt Sinai Hosp. 24, 1121 (1957).

    CAS  Google Scholar 

  26. Schultz, J. C., Adamson, J. S., Workman, W. W., and Norman, T. D.: Fatal liver disease after intravenous administration of tetracycline in high dosage. New Engl. J. Med. 269, 999 (1963).

    Article  PubMed  CAS  Google Scholar 

  27. Ober, W. B., and Lecompte, P. M.: Acute fatty metamorphosis of the liver associated with pregnancy. A distinctive lesion. Amer. J. Med. 19, 743 (1955).

    Article  PubMed  CAS  Google Scholar 

  28. Reye, R. D. K., Morgan, G., and Baral, J.: Encephalopathy and fatty degeneration of the viscera. A disease entity in childhood. Lancet 1964 II, 749.

    Google Scholar 

  29. Cihula, J., Drasner, I., Dvorackova, I., Vortel, V., and Hroch, V.: Encephalitic syndrome with steatosis of the liver. Z. ges. inn. Med. 22, 14 (1967).

    PubMed  CAS  Google Scholar 

  30. Schaffner, F., and Popper, H.: Electron microscopy of human liver disease. In: Modern trends in pathology 2, p. 252. (T. Crawford, Ed.) England: Butterworths 1967.

    Google Scholar 

  31. Popper, H.: Cholestasis. Ann. Rev. Med. 19, 39 (1968).

    Article  PubMed  CAS  Google Scholar 

  32. Popper, H.: Pathogenese und Klassifizierung der Lebercirrhose. Med. Klin. 64, 1 (1969).

    Google Scholar 

  33. Popper, H., Elias, H., and Petty, D. E.: Vascular pattern of the cirrhotic liver. Amer. J. clin. Path. 22, 717 (1952).

    CAS  Google Scholar 

  34. Sheldon, S., Chiandussi, L., Guevera, L., Caesar, J. J., and Sherlock, S.: The measurement of hepatic blood flow and intrahepatic shunted blood flow by colloidal heat-denatured human serum albumin labelled with J131. J. clin. Invest. 40, 1346 (1961).

    Article  Google Scholar 

  35. Schaffner, F., and Popper, H.: Capillarization of hepatic sinusoids in man. Gastroenterology 44, 239 (1963).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Mount Sinai School of Medicine of the City University of New York, N.Y., USA

    H. Popper

Authors
  1. H. Popper
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Wiesbaden, Deutschland

    B. Schlegel

Rights and permissions

Reprints and permissions

Copyright information

© 1969 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Popper, H. (1969). Das morphologische Substrat der Leberinsuffizienz. In: Schlegel, B. (eds) FÜnfundsiebzigster Kongress. Verhandlungen der Deutschen Gesellschaft Für Innere Medizin, vol 75. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47085-1_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-47085-1_5

  • Publisher Name: J.F. Bergmann-Verlag, Munich

  • Print ISBN: 978-3-8070-0277-4

  • Online ISBN: 978-3-642-47085-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation