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Mutation Spectra Resulting from Carcinogenic Exposure: From Model Systems to Cancer-Related Genes

  • Conference paper
Genes and Environment in Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 154))

Abstract

The events leading to cancer are complex and interactive. Alteration of cancer genes, such as the tumor suppressor gene p53, plays a central role in this process. Analysis of the frequency, type and site of mutations in important cancer-related genes may provide clues to the identification of etiological factors and sources of exposure. In this chapter we have selected a few examples of environmental human carcinogens and have attempted to use the knowledge of their mechanisms of mutagenesis, as derived from in vitro cell systems, as a key to understanding the complexity of p53 mutation spectra in tumors arising at the putative target organ. The analysis will focus on environmental exposure to UV radiation. The examples of tobacco smoke, dietary aflatoxin and vinyl chloride will be also briefly discussed.

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Authors and Affiliations

  1. Laboratory of Comparative Toxicology and Ecotoxicology, Viale Regina Elena 299, 00161, Rome, Italy

    E. Dogliotti & M. D’Errico

  2. International Agency for Research on Cancer, 150 cours Albert-Thomas, 69372, Lyon Cedex 08, France

    P. Hainaut & T. Hernandez

  3. Environmental Carcinogenesis Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA

    D. M. Demarini

Authors
  1. E. Dogliotti
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  2. P. Hainaut
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  3. T. Hernandez
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  4. M. D’Errico
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  5. D. M. Demarini
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Editor information

Editors and Affiliations

  1. Abteilung Zytogenetik, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany

    Manfred Schwab

  2. Pathologisches Institut, Universität München, Thalkirchner Straße 36, D-80377, München, Germany

    Hartmut M. Rabes

  3. Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany

    Klaus Munk

  4. Max-Planck-Institut für Biochemie, Am Klopferspitz 18a, D-82152, Martinsried, Germany

    Hans Peter Hofschneider

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© 1998 Springer-Verlag Berlin · Heidelberg

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Dogliotti, E., Hainaut, P., Hernandez, T., D’Errico, M., Demarini, D.M. (1998). Mutation Spectra Resulting from Carcinogenic Exposure: From Model Systems to Cancer-Related Genes. In: Schwab, M., Rabes, H.M., Munk, K., Hofschneider, H.P. (eds) Genes and Environment in Cancer. Recent Results in Cancer Research, vol 154. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46870-4_6

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  • DOI: https://doi.org/10.1007/978-3-642-46870-4_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46872-8

  • Online ISBN: 978-3-642-46870-4

  • eBook Packages: Springer Book Archive

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