Abstract
It has not previously been clear whether cytogenetic biomarkers in healthy subjects will predict cancer. Earlier analyses of a Nordic and an Italian cohort indicated predictivity for chromosomal aberrations (CAS) but not for sister chromatid exchanges (SCES). A pooled analysis of the updated cohorts, forming a joint study base of 5271 subjects, will now be performed, allowing a more solid evaluation. The importance of potential effect modifiers, such as gender, age at testing, and time since testing, will be evaluated using Poisson regression models. Two other potential effect modifiers, occupational exposures and smoking, will be assessed in a case-referent study within the study base.
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References
Aitio A, Becking G et al (1988) Indicators for assessing exposure and biological effects of genotoxic chemicals. Consensus and technical reports. Commission of the European Communities. International Programme on Chemical Safety (UNEP-ILO-WHO), World Health Organization Regional Office for Europe, Institute of Occupational Health, Finland
Bonassi S, Abbondandolo A et al (1995) Are chromosome aberrations in circulating lymphocytes predictive of a future cancer onset in humans? Preliminary results of an Italian cohort study. Cancer Genet Cytogenct 79: 133–135
Clayton D, Hills M (1993) Statistical models in epidemiology. Oxford University Press, Oxford
Hagmar L, Bragger A et al (1994) Cancer risk in humans predicted by increased levels of chromosome aberrations in lymphocytes: Nordic Study Group on the Health Risk of Chromosome Damage. Cancer Res 54: 2919–2922
International Commission for Protection against Environmental Mutagens and Carcinogens (1988) Considerations for population monitoring using cytogenetic techniques. Mutat Res 204: 379–406
Nordic Study Group on the Health Risk of Chromosome Damage (1990a) A Nordic data base on somatic chromosome damage in humans. Mutat Res 241:325–337
Nordic Study Group on the Health Risk of Chromosome Damage (1990b) An inter-Nordic prospective study on cytogenetic endpoints and cancer risk. Cancer Genet Cytogenet 45: 85–92
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© 1998 Springer-Verlag Berlin · Heidelberg
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Hagmar, L. et al. (1998). Cancer Predictive Value of Cytogenetic Markers Used in Occupational Health Surveillance Programs. In: Schwab, M., Rabes, H.M., Munk, K., Hofschneider, H.P. (eds) Genes and Environment in Cancer. Recent Results in Cancer Research, vol 154. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46870-4_10
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DOI: https://doi.org/10.1007/978-3-642-46870-4_10
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