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Fc Receptors on Natural Killer Cells

  • Chapter
Specificity, Function, and Development of NK Cells

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 230))

Abstract

Cytotoxicity and cytokine production represent the two major functional effects that follow interaction of natural killer (NK) cells with a variety of target cells (reviewed in Trinchieri 1989). The receptor(s) involved in binding/recognition of target cells sensitive to spontaneous cytotoxicity (i.e., that mediated by NK cells from healthy nonimmunized individuals against nonsensitized targets) remain elusive. Target cells not bound spontaneously by NK cells can be recognized if coated with intact IgG antibodies, and NK cell recognition of these particulate immune complexes triggers antibody-dependent cell-mediated cytotoxicity (ADCC), following binding to receptors for the Fc portion of Ig (FcR) expressed on these cells. In these conditions, analogous to what is observed upon target cell recognition, cytokine expression and production are also induced with fast kinetics, and the same effects are elicited with monoclonal antibodies (mAb) to these molecules. Recognition of target cells that express major histocompatibility complex (MHC) class I antigens can modulate both FcR-dependent and FcR-independent NK cell activation, indicating that common biochemical events are elicited in both cases.

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Authors and Affiliations

  1. Kimmel Cancer Institute, Jefferson Medical College, BLSB 750, 233 S. 10th Street, Philadelphia, PA, 19107, USA

    B. Perussia

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  1. B. Perussia
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  1. Karolinska Institute, Microbiology and Tumor Biology Center, S-17177, Stockholm, Sweden

    Klas Kärre

  2. Basel Institute for Immunology, Grenzacherstraße 487, CH-4005, Basel, Switzerland

    Marco Colonna M.D.

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Perussia, B. (1998). Fc Receptors on Natural Killer Cells. In: Kärre, K., Colonna, M. (eds) Specificity, Function, and Development of NK Cells. Current Topics in Microbiology and Immunology, vol 230. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46859-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-46859-9_6

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