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Specificity, Function, and Development of NK Cells pp 161–190Cite as

Ontogeny and Differentiation of Murine Natural Killer Cells and Their Receptors

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 230))

Abstract

Cellular immunology was actively investigated during the 1960s, stimulated in large part by the development of plaque assays for antibody-forming cells (Jerne and Nordin 1963) and the assay for cytotoxic cells (Rosenau and Moon 1964). The discovery that the thymus and bursa of Fabricius are necessary for the development of T and B cells (Miller and Mitchell 1969; Glick and Whatley 1967; Cooper et al. 1965) led to the concept of “central lymphoid organs.” Subsequently it appeared that the effector cell responsible for rejection of bone marrow allografts following large doses of total-body irradiation is not a T or a B cell, but is eliminated by destruction of bone marrow with the bone-seeking isotope 89Sr (Cudkowlcz and Bennett 1971; Bennett 1973). Thus these effector cells were termed “marrow-dependent” or M cells, based on the analogy with the thymus and bursa-dependent T and B cell. Later studies revealed that M cells are identical to natural killer (NK) cells.

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Authors and Affiliations

  1. Department of Pathology and Graduate Program in Immunology, University of Texas Southwestern Medical Center, Department of Pathology, 6000 Harry Hines Blvd., Dallas, TX, 75235-9072, USA

    P. V. Sivakumar, I. Puzanov, N. S. Williams, M. Bennett & V. Kumar

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  1. P. V. Sivakumar
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  2. I. Puzanov
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  3. N. S. Williams
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  4. M. Bennett
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  5. V. Kumar
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Editors and Affiliations

  1. Karolinska Institute, Microbiology and Tumor Biology Center, S-17177, Stockholm, Sweden

    Klas Kärre

  2. Basel Institute for Immunology, Grenzacherstraße 487, CH-4005, Basel, Switzerland

    Marco Colonna M.D.

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Sivakumar, P.V., Puzanov, I., Williams, N.S., Bennett, M., Kumar, V. (1998). Ontogeny and Differentiation of Murine Natural Killer Cells and Their Receptors. In: Kärre, K., Colonna, M. (eds) Specificity, Function, and Development of NK Cells. Current Topics in Microbiology and Immunology, vol 230. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46859-9_11

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