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Assessment of Animal Tumour Promotion Data for the Human Situation

  • Conference paper
Diversification in Toxicology — Man and Environment

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 20))

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Abstract

There is considerable evidence that cancer development in humans and experimental animals includes different stages that are results of interactions between target cells and various endogenous/exogenous factors. In order to protect man from chemically induced cancer, the development of suitable test systems for the detection of carcinogenic potency has been and still is an important task of applied toxicological research. Conventional cancer bioassays in which rodents are exposed to a certain chemical over two years is commonly used to investigate possible carcinogens. This test procedure is costly with respect to time and money and makes use of a large number of animals.

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Abbreviations

PCB:

polychlorinated biphenyl

PCB:

126, 3,4,5,3′,4′-pentachlorobiphenyl

PCB:

118, 2,4,5,3′,4′-pentachlorobiphenyl

PCB:

153, 2,4,5,2′,4,5-hexachlorobiphenyl

CYP:

cytochrome P-450

PH:

partial hepatectomy

AHF:

altered hepatic foci

EROD:

7-ethoxyresorufin-O-dealkylase

PROD:

7-pentoxyresorufin-O-dealkylase

cx:

connexin

Ah:

aryl hydrocarbon

GST-P:

glutathione-S-transferase P

GJIC:

gap junctional intercellular communication.

References

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Author information

Authors and Affiliations

  1. Institute of Environmental Medicine, Karolinska Institutet, Box 210, S-171 77, Stockholm, Sweden

    Lars Wärngård, Marie Haag-Grönlund & Yvonne Bager

  2. Astra AB, S-151 85, Södertälje, Sweden

    Lars Wärngård

Authors
  1. Lars Wärngård
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  2. Marie Haag-Grönlund
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  3. Yvonne Bager
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Editor information

Editors and Affiliations

  1. Intercantonal Office for the Control of Medicines(IOCM), Erlachstrasse 8, CH-3000, Bern 9, Switzerland

    Jürg P. Seiler

  2. Krathusvej 2A, DK-8240, Risskov, Denmark

    Judith L. Autrup

  3. Steno Institute of Public Health, University of Åarhus, Universitetsparken, Bldg. 180, DK-8000, Åarhus C, Denmark

    Herman Autrup

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© 1998 Springer-Verlag Berlin Heidelberg

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Wärngård, L., Haag-Grönlund, M., Bager, Y. (1998). Assessment of Animal Tumour Promotion Data for the Human Situation. In: Seiler, J.P., Autrup, J.L., Autrup, H. (eds) Diversification in Toxicology — Man and Environment. Archives of Toxicology, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46856-8_28

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  • DOI: https://doi.org/10.1007/978-3-642-46856-8_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46858-2

  • Online ISBN: 978-3-642-46856-8

  • eBook Packages: Springer Book Archive

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