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Prognostic Implications of Symptomatic Behaviors in Alzheimer’s Disease

  • Conference paper
Heterogeneity of Alzheimer’s Disease

Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

Summary

Symptomatic behaviors frequently accompany Alzheimer’s disease (AD) and include disturbances of mood, perception, and motor activity. The frequency of such symptoms reported in the literature varies depending upon symptom definition and stage of illness, but usually ranges between 20 to 40%. The biological bases that underlie these disturbances are not well understood, but probably related to the presence of specific pathological and neurochemical substrates (e.g., disproportionate pathology in limbic/paralimbic structures of the frontal-temporal lobes or changes in biogenic amine systems). A number of investigators, using different strategies and analytic methods, have shown that symptomatic behaviors are associated with a faster rate of cognitive decline. The biological significance of this association between behavior and cognition is unknown. It is conceivable, however, that the same distribution of pathologic lesions and neurochemical changes that predispose to psychosis may also hasten the rate of cognitive decline.

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Authors
  1. H. C. Chui
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  2. S. Lyness
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  3. E. Sobel
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  4. L. S. Schneider
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Editor information

Editors and Affiliations

  1. INSERM U324, 2ter rue de Alesia, F-75015, Paris, France

    Francois Boller

  2. Hopital Broca, 54 rue Pascal, F-75013, Paris, France

    F. Forette

  3. National Institute on Aging, National Institute of Health, Bethesda, MD, 20892, USA

    Z. S. Khachaturian

  4. Clinique de Neurologie, CHU La Timone, Bd Jean Moulin, F-13385, Marseille Cedex 05, France

    Michel Poncet

  5. Fondation Ipsen pour La Recherche Therapeutique, 30, rue Cambronne, F-75737, Paris Cedex 15, France

    Yves Christen PH. D.

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© 1992 Springer-Verlag Berlin Heidelberg

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Chui, H.C., Lyness, S., Sobel, E., Schneider, L.S. (1992). Prognostic Implications of Symptomatic Behaviors in Alzheimer’s Disease. In: Boller, F., Forette, F., Khachaturian, Z.S., Poncet, M., Christen, Y. (eds) Heterogeneity of Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46776-9_3

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  • DOI: https://doi.org/10.1007/978-3-642-46776-9_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46778-3

  • Online ISBN: 978-3-642-46776-9

  • eBook Packages: Springer Book Archive

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