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Alzheimer’s Disease: many Aetiologies; one Pathogenesis

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Heterogeneity of Alzheimer’s Disease

Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

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Summary

Recent genetic studies have clearly shown that Alzheimer’s disease (AD) has several aetiologies. Some cases have defined mutations in the β-amyloid precursor protein (APP) gene, others do not. Persons with Down’s syndrome presumably get AD because they constitutively overexpress APP. Despite these differences in aetiology, all cases seem to have similar clinical and pathological features. The simplest explanation of the fact that there are several aetiologies, but a single pathology, is that a pathological cascade occurs which can be triggered in several ways. It is not yet clear whether there are small clinical and pathological differences between cases with different aetiologies.

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Authors
  1. J. Hardy
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Editor information

Editors and Affiliations

  1. INSERM U324, 2ter rue de Alesia, F-75015, Paris, France

    Francois Boller

  2. Hopital Broca, 54 rue Pascal, F-75013, Paris, France

    F. Forette

  3. National Institute on Aging, National Institute of Health, Bethesda, MD, 20892, USA

    Z. S. Khachaturian

  4. Clinique de Neurologie, CHU La Timone, Bd Jean Moulin, F-13385, Marseille Cedex 05, France

    Michel Poncet

  5. Fondation Ipsen pour La Recherche Therapeutique, 30, rue Cambronne, F-75737, Paris Cedex 15, France

    Yves Christen PH. D.

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© 1992 Springer-Verlag Berlin Heidelberg

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Hardy, J. (1992). Alzheimer’s Disease: many Aetiologies; one Pathogenesis. In: Boller, F., Forette, F., Khachaturian, Z.S., Poncet, M., Christen, Y. (eds) Heterogeneity of Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46776-9_11

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  • DOI: https://doi.org/10.1007/978-3-642-46776-9_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46778-3

  • Online ISBN: 978-3-642-46776-9

  • eBook Packages: Springer Book Archive

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