Abstract
The successful identification of the defective gene in a number of heritable diseases (i.e., Duchenne muscular dystrophy, neurofibromatosis, fragile X syndrome) using molecular genetic techniques has stimulated several scientists to use a similar approach to Alzheimer’s disease (AD), the major cause of senile dementia in the Western population (Davies 1986).
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References
Bakker E, Van Broeckhoven C, Haan Jet al. (1991) DNA diagnosis for hereditary cerebral haemorrhage with amyloidosis ( Dutch type ). Am J Hum Genet 49: 518–521
Chartier-Harlin M-C, Crawford F, Hamandi K et al. (1991a) Screening for the ß-amyloid precursor protein mutation (APP717:Val- I1e) in extended pedigrees with early onset Alzheimer’s disease. Neurosci Lett 129: 134–135
Chartier-Harlin M-C, Crawford F, Houlden H et al. (1991b) Early-onset Alzheimer’s disease caused by mutations at codon 717 of the ß-amyloid precursor protein gene. Nature 353: 844–846
Davies P (1986) Genetics of Alzheimer’s disease: a review and a discussion of the implications. Neurobiol Aging 7: 459–466
Goate AM, Owen MJ, James LA et al. (1989) Predisposing locus for Alzheimer’s disease on chromosome 21. Lancet 1: 352–355
Goate AM, Chartier-Harlin M-C, Mullan M et al. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature 349: 704–706
Haan J, Hardy JA, Ross RAC (1991) Hereditary cerebral haemorrhage with amyloidosis–Dutch type: its importance for Alzheimer research. Trends Neurosci 14: 231–234
Kang J, Lemaire H-G, Unterbeck A et al. (1987) The precursor of Alzheimer’ s disease amyloid A4 protein. Nature 325: 733–736
Levy E, Carman MD, Fernandez-Madrid I et al. (1990) Mutation of the Alzheimer’s disease amyloid gene in hereditary cerebral haemorrhage, Dutch type. Science 248: 1124–1126
Martin J-J, Gheuens J, Bruyland M et al. (1991) Early-onset Alzheimer’ s disease in 2 large Belgian families. Neurology 41: 62–68
Murrell J, Farlow M, Ghetti B, Benson D (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer’s disease. Science 254: 97–99
Naruse S, Igarashi S, Kobayashi H et al. (1991) Mis-sense mutation Val-Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer’s disease. Lancet 337: 979
Pericak-Vance MA, Yamaoka LH, Haynes CS et al. (1988) Genetic linkage in Alzheimer’s disease families. Exp Neurol 102: 271–279
Pericak-Vance MA, Bebout JL, Gaskell PC Jr et al. (1991) Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. Am J Hum Genet 49: 1034–1050
Potter H (1991) Review and hypothesis: Alzheimer disease and Down syndrome–chromosome 21 non-disjunction may underlie both disorders. Am J Hum Genet 48: 1192–1200
Schellenberg GD, Bird TD, Wijsman EM et al. (1988) Absence of linkage of chromosome 21q21 markers to familial Alzheimer’s disease. Science 241: 1507–1510
Schellenberg GD, Anderson L, O’Dahl S et al. (1991a) APP.,7, APPb93, and PRIP gene mutations are rare in Alzheimer disease. Am J Hum Genet 49: 511–517
Schellenberg GD, Pericak-Vance MA, Wijsman EM et al. (1991b) Linkage analysis of familial Alzheimer disease, using chromosome 21 markers. Am J Hum Genet 48: 563–583
St. George-Hyslop PH, Tanzi RE, Polinsky RJ et al. (1987) The genetic defect causing familial Alzheimer’ s disease maps on chromosome 21. Science 253: 885–890
St. George-Hyslop PH, Haines JL, Farrer LA et al. (1990) Genetic linkage studies suggest that Alzheimer’s disease is not a single homogeneous disorder. Nature 347: 194–197
Tanzi RE, Gusella JF, Watkins PC et al. (1987a) Amyloid ß protein gene: cDNA, mRNA distribution and genetic linkage near the Alzheimer locus. Science 235: 880–884
Tanzi RE, St. George-Hyslop PH, Haines JL et al. (1987b) The genetic defect in familial Alzheimer’ s disease is not tightly linked to the amyloid ß-protein gene. Nature 329: 156–157
Van Broeckhoven C, Genthe CA, Vandenberghe A et al. (1987) Failure of familial Alzheimer’s disease to segregate with the A4 amyloid gene in several European families. Nature 329: 153–155
Van Broeckhoven C, Haan J, Bakker E et al. (1990a) Amyloid beta protein precursor gene and hereditary cerebral haemorrhage with amyloidosis ( Dutch ). Science 248: 1120–1122
Van Broeckhoven C, Backhovens H, Van Hul W et al. (1990b) Genetic linkage analysis in early-onset familial Alzheimer’s disease. In: Bunney WE Jr, Hippius H, Laakmann G, Schmauss M (eds) Neuropsychopharmacology. Springer, Berlin Heidelberg New York, pp 86–91
Van Duijn CM, Hendriks L, Cruts M et al. (1991) Amyloid precursor protein gene mutation in early-onset Alzheimer’s disease. Lancet 337: 978
Wicking C, Williamson R (1991) From linked marker to gene. Trends Genet 7: 288–293
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Van Broeckhoven, C., Martin, JJ. (1992). Molecular Genetics of Familial Alzheimer’s Disease. In: Mendlewicz, J., Hippius, H., Bondy, B., Ackenheil, M., Sandler, M. (eds) Genetic Research in Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46762-2_7
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DOI: https://doi.org/10.1007/978-3-642-46762-2_7
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