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Epitopes on Allergens

  • Conference paper
New Trends in Allergy III

  • 141 Accesses

Abstract

By conventional immunological and physicochemical techniques natural allergens have been separated into antigenic and allergenic fractions. During the last years new methodological developments enabled to investigate their structures in detail. The first step was the identification of antigenic and allergenic (IgE-binding) epitopes on these molecules. This has been done for several major allergens from pollen, insect, fungal and epidermal allergens e.g. Usually 2–6 antigenic and 1–3 allergenic sites have been found. In some cases the primary structure of such epitopes or even the complete allergen has been uncovered. In a few of them (Der p I, Chi 11 e.g.) even the three-dimensional structure could be disclosed. Obviously sequential epitopes dominante — at least in grass pollen allergens. The methods which have been applied are monoclonal antibodies, improved techniques of peptide analysis and synthesis and above all cloning procedures.

These developments are very important both from practical and theoretical points of view. They will improve diagnostic procedures and disclose the basis of often surprising cross-reactivities. More important is the fact that B-cell-epitopes (being active during the manifestation of the allergic reaction) are obviously not identical with T-cell epitopes (important during sensitization). This fact could open new ways for a scientific-based approach to immuntherapy. Other prospective developments concern the presentation of these epitopes together with MHC-structures, the identification of possibly individual-specific patterns of sensitization and an reevaluation of the exact mechanisms of the initial step of IgE-medi-ated reactions. The dogma that bridging of membrance-bound IgE antibodies is induced by identical epitopes obviously has to be modified.

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Author information

Authors and Affiliations

  1. Department of Clinical Immunology, Friedrich Schiller University, Bachstrasse 18, O-6900, Jena, Federal Republic of Germany

    L. Jäger, C. Diener, W.-D. Müller & G. Schlenvoigt

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  1. L. Jäger
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  2. C. Diener
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  3. W.-D. Müller
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  4. G. Schlenvoigt
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Editors and Affiliations

  1. Hautklinik und Allergie-Abteilung, Universitäts-Krankenhaus Eppendorf, Martinistrasse 52, 2000, Hamburg 20, Federal Republic of Germany

    Johannes Ring

  2. Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Frauenlobstrasse 9-11, 8000, München 2, Federal Republic of Germany

    Bernhard Przybilla

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© 1991 Springer-Verlag Berlin Heidelberg

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Jäger, L., Diener, C., Müller, WD., Schlenvoigt, G. (1991). Epitopes on Allergens. In: Ring, J., Przybilla, B. (eds) New Trends in Allergy III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46717-2_4

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  • DOI: https://doi.org/10.1007/978-3-642-46717-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46719-6

  • Online ISBN: 978-3-642-46717-2

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