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Neuronal Interaction with Mast Cells

  • Conference paper
New Trends in Allergy III

  • 142 Accesses

Abstract

There is significant information available in the literature suggesting that nerves can influence mast cells. Neurotransmitters are able to cause mast cells to secrete mediators in vitro. Stimulation of nerves can result in mast cell degranulation. Stimulation of nerves ex vivo by field stimulation can result in mast cell degranulation with consequent physiological effects. In experimental situations antigen will cause IgE-dependent/mast cell-dependent/nerve-dependent effects both on intestinal and respiratory tract epithelial cell integrity and physiological changes recorded as short circuit current in Ussing chambers. In vitro co-culture of mast cells with nerves grown from superior cervical ganglia show selective association and contact with mast cells, again with physiological consequences. In Pavlovian conditioning experiments of rats, we have been able to show after suitable training, associating antigen injection in sensitized animals with an appropriate stimulus, that on exposure to the stimulus alone, intestinal mast cell degranulation occurred with physiological consequences. Many of these results suggest a bi-directional communication between mast cells and nerves and it is likely that these may have, by extrapolation, significant implications for human physiology and disease.

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Author information

Authors and Affiliations

  1. Department of Pathology and Intestinal Diseases Research Unit, McMaster University, 2E1, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Ontario, Canada

    J. Bienenstock, M. H. Perdue & R. H. Stead

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  1. J. Bienenstock
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  2. M. H. Perdue
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  3. R. H. Stead
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Editors and Affiliations

  1. Hautklinik und Allergie-Abteilung, Universitäts-Krankenhaus Eppendorf, Martinistrasse 52, 2000, Hamburg 20, Federal Republic of Germany

    Johannes Ring

  2. Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Frauenlobstrasse 9-11, 8000, München 2, Federal Republic of Germany

    Bernhard Przybilla

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© 1991 Springer-Verlag Berlin Heidelberg

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Bienenstock, J., Perdue, M.H., Stead, R.H. (1991). Neuronal Interaction with Mast Cells. In: Ring, J., Przybilla, B. (eds) New Trends in Allergy III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46717-2_25

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  • DOI: https://doi.org/10.1007/978-3-642-46717-2_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46719-6

  • Online ISBN: 978-3-642-46717-2

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