Abstract
Prostaglandin (PG) D2 is a naturally occurring prostanoid that shows various kinds of pharmacological activity, such as inhibition of platelet aggregation, bronchoconstriction, sleep induction, and hypothermia, under various physiological and pathological conditions [1–3]. PGD2 is known to be actively produced by mast cells during IgE stimulation and to modify the anaphylactic process [4].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ikai K, Imamura S (1988) Prostaglandin D2 in the skin. Int J Dermatol 27:141–149
Ujihara M, Urade Y, Eguchi N, Hayashi H, Ikai K, Hayaishi O (1988) Prostaglandin D2 formation and characterization of its synthetases in various tissues of adult rat. Arch Biochem Biophys 260:521–531
Ito S, Narumiya S, Hayaishi O (1989) Prostaglandin D2: a biochemical perspective. Prostaglandins Leuko Essent Fatty Acids 37:219–234
Lewis RA, Soter NA, Diamond PT, Austin KF, Oates JA, Roberts LJII (1982) Prostaglandin D2 generation after activation of rat and human mast cells. J Immunol 129:1627–1631
Urade Y, Fumimoto N, Hayaishi O (1985) Purification and characterization of rat brain prostaglandin D synthetase. J Biol Chem 260:12410–12415
Urade Y, Fujimoto N, Ujihara M, Hayaishi O (1987) Biochemical and immunological characterization of rat spleen prostaglandin synthetase. J Biol Chem 262:3820–3825
Urade Y, Nagata A, Suzuki Y, Fujii Y, Hayaishi O (1987) Primary structure of rat brain prostaglandin D synthetase deduced from cDNA sequence. J Biol Chem 262:15132–15136
Ujihara M, Tsuchida S, Satoh K, Sato K, Urade Y (1988) Biochemical and immunological demonstration of prostaglandin D2, E2, and F2α formation from prostaglandin H2 by various rat glutathione S-transferase isozymes. Arch Biochem Biophys 264:428–437
Ujihara M, Horiguchi Y, Ikai K, Urade Y (1988) Characterization and distribution of prostaglandin D synthetase in rat skin. J Invest Dermatol 90:448 – 451
Urade Y, Ujihara M, Horiguchi Y, Ikai K, Hayaishi O (1989) The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. J Immunol 143:2982–2989
Urade Y, Ujihara M, Horiguchi Y, Igarashi, Nagata A, Ikai K, Hayaishi O (1990) Mast cells contain spleen-type prostaglandin D synthetase. J Biol Chem 265:371–375
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Ikai, K., Ujihara, M., Horiguchi, Y., Urade, Y. (1991). Prostaglandin D Synthetase Is Localized in Antigen Presenting Cells and Mast Cells. In: Ring, J., Przybilla, B. (eds) New Trends in Allergy III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46717-2_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-46717-2_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-46719-6
Online ISBN: 978-3-642-46717-2
eBook Packages: Springer Book Archive