Abstract
N-Nitrosodialkylamines are a unique class of environmental carcinogens which can cause tumors in rodents in a very organ specific manner. The mechanisms for these properties still await clarification. Possible involved parameters could be an organ specific metabolic activation, or the pharmacokinetics of the compounds or of the reactive intermediates. Furthermore, the repair mechanisms, which consequently govern the persistance of specific types of DNA damage may also play an important role. We are presently studying in which manner these individual mechanisms may contribute to organ specific effects of nitrosamines. This is done by assessing their genotoxicity in different organs. In this report, we will present some in vitro and in vivo data on the activities of N-nitrosodimethylamine (NDMA).
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© 1990 Springer-Verlag Berlin Heidelberg
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Brendler, S.Y., Schmezer, P., Hutter, KJ., Tompa, A., Pool-Zobel, B.L. (1990). Systemic Genotoxic Effects of N-Nitrosodimethylamine. In: Seemayer, N.H., Hadnagy, W. (eds) Environmental Hygiene II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46712-7_6
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DOI: https://doi.org/10.1007/978-3-642-46712-7_6
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