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Biological Markers of Alzheimer’s Disease pp 30–38Cite as

Probes for the Molecular Components of Plaques and Tangles Point to a Broadening View of Alzheimer Pathology

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Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

Summary

The use of new antibody and cDNA probes has broadened our view as to the anatomical loci of the lesions in Alzheimer’s disease. Amyloid is deposited in many locations in the central nervous system, including areas that are not clinically affected by the disease process. Likewise, the neurofibrillary lesions are seen in locations beyond the classical distribution of NFT; however, these lesions do remain restricted to regions such as the hippocampus, cerebrocortical association areas, and certain limbic and brainstem nuclei that are affected clinically. Associated with the neurofibrillary lesions are some of the light microscopic stigmata of a growth or regenerative response. The stimulus for this response may arise as a result of the deposition of β-amyloid protein. Regenerative-type neurites are present in neurons undergoing degeneration, and therefore these processes occur concurrently in the same cell. A major component of the neuritic response is the microtubule-associated protein tau, which we have shown to undergo development ally regulated splicing. One of the previously reported sequences obtained directly from paired helical filament preparations corresponds to an immature tau isoform. The presence of an immature isoform in the paired helical filament may occur as a recapitulation of development, and its presence within a mature cellular milieu may be associated with the assembly of tau into filaments.

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Authors
  1. K. S. Kosik
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  2. D. J. Selkoe
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Editor information

Editors and Affiliations

  1. Inserm U324, 2 ter, rue d’Alesia, 75014, Paris, France

    François Boller

  2. University of California at San Diego, La Jolla, USA

    Robert Katzman

  3. Hôpital Purpan, Toulouse, France

    André Rascol

  4. Hôpital Salpêtrière, Paris, France

    Jean-Louis Signoret

  5. Fondation IPSEN pour la Recherche Thérapeutique, 30, rue Cambronne, F-75737, Paris Cédex, France

    Yves Christen

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© 1989 Springer-Verlag Berlin Heidelberg

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Kosik, K.S., Selkoe, D.J. (1989). Probes for the Molecular Components of Plaques and Tangles Point to a Broadening View of Alzheimer Pathology. In: Boller, F., Katzman, R., Rascol, A., Signoret, JL., Christen, Y. (eds) Biological Markers of Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46690-8_4

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  • DOI: https://doi.org/10.1007/978-3-642-46690-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46692-2

  • Online ISBN: 978-3-642-46690-8

  • eBook Packages: Springer Book Archive

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