Summary
Evidence for a genetic basis to Alzheimer’s disease includes several families of early onset, where the disease appears to segregate as a fully penetrant autosomal dominant disorder. The familial Alzheimer’s disease (FAD) locus can be localised to a region of chromosome 21 by cosegregation of anonymous DNA markers with the disease phenotype. New data confirming the original linkage is presented and in addition suggests the location of the Alzheimer’s disease gene as being centromeric of markers S1/S11 on the proximal long arm of chromsome 21. Each of the six pedigrees used in the recent study have disease onset below 62 years of age, with affected individuals present in at least two generations. The inability of other groups to find linkage of FAD to chromosome 21 (Schellenberg et al. 1988; Pericak-Vance et al. 1988) is discussed and their data shown to be consistent with our finding in early onset Alzheimer’s disease.
This research was supported by grants provided by the Medical Research Council, the Mental Health Foundation, and Research into Ageing.
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Haynes, A.R. et al. (1989). Alzheimer’s Disease and Chromosome 21. In: Boller, F., Katzman, R., Rascol, A., Signoret, JL., Christen, Y. (eds) Biological Markers of Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46690-8_14
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DOI: https://doi.org/10.1007/978-3-642-46690-8_14
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