Molecular Features and Basic Understanding of Protein-Carbohydrate Interactions: The Arabinose-Binding Protein-Sugar Complex
Protein-carbohydrate interactions play an important role in a wide range of biological and biochemical processes. The carbohydrate-binding proteins and enzymes that have been extensively studied show wide diversity in size, subunit composition and three-dimensional structure (Quiocho 1986). Moreover, there is variation in the nature of the carbohydrate ligands, which range from simple monosaccharides to polysaccharides, either free, such as glycogen and starch, or conjugated polymers such as glycoproteins and glycolipids. Despite this diversity and variability the molecular basis of the mode of binding of sugar substrates shows common features (Quiocho 1986).
KeywordsHydrogen Bond Donor Bind Site Residue Sugar Substrate Essential Residue Hydrogen Bond Donor Group
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