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The Transport of Amines Across the Axonal Membranes of Noradrenergic and Dopaminergic Neurones

  • Chapter
Catecholamines I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 90 / 1))

Abstract

In contrast to acetylcholine, which is removed at cholinergic junctions by enzymic degradation, the transmitter noradrenaline is primarily inactivated by membrane transport. Two membrane transport processes are capable of removing noradrenaline and other catecholamines from the extracellular fluid: neuronal and extraneuronal uptake. While the mechanisms related to the latter will be dealt with elsewhere in this volume by Trendelenburg (see Chap. 6), the present chapter is intended to cover mechanisms related to the neuronal fate of catecholamines. It will concentrate on recent results and consider aspects that have not been extensively treated in earlier reviews and books (e.g. Iversen 1967, 1975; von Euler 1972; Hertting and Suko 1972; Paton 1976a). The main emphasis is given to the amine carrier system associated with the axonal membrane of noradrenergic neurones.

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  1. K.-H. Graefe
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  2. H. Bönisch
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  1. Department of Pharmacology and Toxicology, University of WĂĽrzburg, Versbacher Str. 9, D-8700, WĂĽrzburg, Germany

    U. Trendelenburg (Professor Dr.) (Professor Dr.)

  2. Department of Pharmacology, Colorado University, Medical Center, 4200 East Ninth Street, 802 62, Denver, CO, USA

    N. Weiner (Professor Dr.) (Professor Dr.)

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Graefe, KH., Bönisch, H. (1988). The Transport of Amines Across the Axonal Membranes of Noradrenergic and Dopaminergic Neurones. In: Trendelenburg, U., Weiner, N. (eds) Catecholamines I. Handbook of Experimental Pharmacology, vol 90 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46625-0_4

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