Abstract
Secretion by exocytosis—a term introduced by de Duve (1963)—involves the fusion of the membrane of the catecholamine-storing vesicles with that of the cell, followed by the discharge of the soluble contents of this organelle directly into the extracellular space. When the first Handbook on Catecholamines (Blaschko and Muscholl 1972) was published, the chapter on the secretion of catecholamines (Smith and Winkler 1972) already presented exocytosis as the well established secretion mechanism for adrenal medulla and more tentatively also for sympathetic nerves. In the meantime many additional papers have been published, which have confirmed and extended this concept (550 of the 622 publications cited in this review appeared after 1972). On the other hand, the molecular mechanisms involved in exocytosis are still a matter of speculation.
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Winkler, H. (1988). Occurrence and Mechanism of Exocytosis in Adrenal Medulla and Sympathetic Nerve. In: Trendelenburg, U., Weiner, N. (eds) Catecholamines I. Handbook of Experimental Pharmacology, vol 90 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46625-0_2
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