Skip to main content

Erhöhte Plasmalipide — ein Risikofaktor für die vorzeitige Arteriosklerose

  • Conference paper
  • 16 Accesses

Part of the book series: Sitzungsberichte der Heidelberger Akademie der Wissenschaften ((1008,volume 1986 / 2))

Zusammenfassung

Für die vorzeitige Entwicklung der Gefäßarteriosklerose, die sich oft durch Herzinfarkt schon im mittleren Lebensalter manifestiert, spielen Fettstoffwechselstörungen und besonders erhöhte Blutcholesterinspiegel als ein eigenständiger primärer Risikofaktor eine bedeutende Rolle. Da jedoch die Blutfettwerte in offenbar gesunden Bevölkerungsgruppen stark variieren, kann es im Einzelfall oft schwierig sein, den Risikofaktor Hypercholesterinämie zu ermitteln. Als sicher pathologisch gelten Blutfettwerte, wenn sie eine Stoffwechselstörung selbst anzeigen, z. B. bei einer genetischen Hypercholesterinämie. In den westlichen Industriegesellschaften sind in der Bevölkerung insgesamt die Blutfette höher. Wir behelfen uns, indem wir Blutfettwerte jenseits der 95. Perzentile als pathologisch ansehen.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Albers JJ, Cheng MC, Hazzard WR (1978) High density lipoproteins in myocardial infarction survivors. Metabolism 27:479–485

    Article  PubMed  CAS  Google Scholar 

  • Assmann G (1982) Lipid metabolism and atherosclerosis. Schattauer Verlag, Stuttgart New York

    Google Scholar 

  • Berg K, Borresen A, Dehlen G (1976) Serum-high-density lipoprotein and atherosclerotic heart disease. Lancet 1:499–501

    Article  PubMed  CAS  Google Scholar 

  • Brown MS, Goldstein JL (1975) Lipoprotein receptors and the genetic control of cholesterol metabolism in cultured human cells. Naturwissenschaften 62:385–389

    Article  PubMed  CAS  Google Scholar 

  • Brown MS, Goldstein JL (1979) Receptor-mediated endocytosis: Insights from the lipoprotein receptor system. Proc Natl Acad Sci USA 76:3330–3334

    Article  PubMed  CAS  Google Scholar 

  • Brown MS, Kovanen PT, Goldstein JL (1981) Regulation of plasma cholesterol by lipoprotein receptors. Science 212:628–635

    Article  PubMed  CAS  Google Scholar 

  • Brown MS, Goldstein JL (1983) Lipoprotein receptor in the liver. J Clin Invest 72:743–747

    Article  PubMed  CAS  Google Scholar 

  • Fielding CJ (1978) Origin and properties of remnant lipoproteins. In: Dietschy JM, Gotto AM Jr, Ontko JA (Hrsg) Disturbances in lipid and lipoprotein metabolism. Waverly Press, Inc, Baltimore, S 83–98

    Google Scholar 

  • Fredrickson DS, Levy RI, Lees RS (1967) Fat transport in lipoproteins — an integrated approach to mechanisms and disorders. N Engl J Med 276:32, 94, 148, 215, 273

    Google Scholar 

  • Fredrickson DS, Levy RI (1972) Familial hyperlipoproteinemia. In: Stanbury JB, Wyngaarden JB, Fredrickson DS (Hrsg) Metabolic basis of inherited diseases. McGraw-Hill, New York, S 545–614

    Google Scholar 

  • Fredrickson DS, Goldstein JL, Brown MS (1978) The familial hyperlipoproteinemias. In: Stanbury JB, Wyngaarden JB, Fredrickson DS (Hrsg) Metabolic basis of inherited diseases. McGraw-Hill, New York, S 604–655

    Google Scholar 

  • Goldstein JL, Hazzard WG, Schrott HG, Bierman E, Motulsky AG (1973) Hyperlipidemia in coronary artery disease. I. Lipid levels in 500 survivors of myocardial infarction. J Clin Invest 52:1533–1550

    Article  PubMed  CAS  Google Scholar 

  • Goldstein JL, Schrott HG, Hazzard WR, Bierman EL, Motulsky AG (1973) Hyperlipidemia in coronary artery disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J Clin Invest 52:1544–1568

    Article  PubMed  CAS  Google Scholar 

  • Goldstein JL, Brown MS (1977) The low density lipoprotein pathway and its relation to atherosclerosis. Ann Rev Biochem 46:897–930

    Article  PubMed  CAS  Google Scholar 

  • Goldstein JL, Brown MS (1979) The LDL receptor locus and the genetics of familial hypercholesterolemia. Ann Rev Genet 13:259–289

    Article  PubMed  CAS  Google Scholar 

  • Goldstein JL, Brown MS (1984) Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol. J Lipid Res 25:1450–1461

    PubMed  CAS  Google Scholar 

  • Gotto AM Jr (1978) Hyperlipidemia: Finding the patient at risk. Mod Medicine 6:62–74

    Google Scholar 

  • Humphries SE, Horsthemke B, Seed M, Holm M, Wynn V, Kessling AM, Donald JA, Jowett N, Galton DJ, Williamson R (1985) A common DNA polymorphism of the LDL receptor gene and its use in diagnosis. Lancet May 4, 1985:1003–1006

    Article  Google Scholar 

  • Inkeles S, Eisenberg D (1981) Hyperlipidemia and coronary atherosclerosis: a review. Medicine 60:110–123

    Article  PubMed  CAS  Google Scholar 

  • Lehrman MA, Goldstein JL, Brown MS, Russell DW, Schneider WJ (1985) Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain. Cell 41:735–743

    Article  PubMed  CAS  Google Scholar 

  • Lewis B (1981) Genes and nutrition in the regulation of human lipoprotein metabolism. Klin Wschr 59:1037–1042

    Article  PubMed  CAS  Google Scholar 

  • Mahley RW, Hui DY, Innerarity TL, Weisgraber KH (1981) Two independent lipoprotein receptors on hepatic membranes of dog, swine and man. J Clin Invest 68:1192–1206

    Article  Google Scholar 

  • Mahley RW (1983) Apolipoprotein E and cholesterol metabolism. Klin Wschr 61:225–232

    Article  PubMed  CAS  Google Scholar 

  • Mahley RW, Innerarity TL, Rall SC Jr, Weisgraber KH (1984) Plasma lipoproteins: apoprotein structure and function. J Lipid Res 25:1277–1294

    PubMed  CAS  Google Scholar 

  • Miller NE (1979) Plasma lipoproteins, lipid transport, and atherosclerosis: recent developments. J Clin Pathol 32:639–650

    Article  PubMed  CAS  Google Scholar 

  • Miller NE, La Ville A, Cook D (1985) Direct evidence that reverse cholesterol transport is mediated by high density lipoprotein in rabbit. Nature 314:109–111

    Article  PubMed  CAS  Google Scholar 

  • Pittman RC, Steinberg G (1984) Sites and mechanisms of uptake and degradation of high density and low density lipoproteins. J Lipid Res 25:1577–1585

    PubMed  CAS  Google Scholar 

  • Russell DW, Schneider WJ, Yamamoto T, Luskey KL, Brown MS, Goldstein JL (1984) Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor. Cell 37:577–585

    Article  PubMed  CAS  Google Scholar 

  • Schmitz G, Robeneck H, Lohmann U, Assmann G (1985) Interaction of HDL with cholesteryl ester laden macrophages: biochemical and morphological characterization of cell surface receptor binding endocytosis and resecretion of HDL by macrophages. The EMBO J 4:613–622

    CAS  Google Scholar 

  • Schneider WJ, Kovanen PT, Brown MS, Goldstein JL, Utermann G, Weber W, Havel RJ, Kotite L, Kane JP, Innerarity TL, Mahley RW (1981) Familiar dysbetalipoproteinemia: Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenals of rats, rabbits, and cows. J Clin Invest 68:1075–1085

    Article  PubMed  CAS  Google Scholar 

  • Sherill BC, Innerarity TL, Mahley RW (1980) Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process. J Biol chem 255:1804–1807

    Google Scholar 

  • Sparks JD, Sparks CE (1985) Apolipoprotein B and lipoprotein metabolism. Adv Lipid Res 24:1–47

    Article  Google Scholar 

  • Steinberg D (1983) Lipoproteins and atherosclerosis. A look back and a look ahead. Arteriosclerosis 3:283–301

    Article  PubMed  CAS  Google Scholar 

  • Südhof TC, Goldstein JL, Brown MS, Russell DW (1985) The LDL receptor gene: A mosaic of exons shared with different proteins. Science 228:885–893

    Article  Google Scholar 

  • Südhof TC, Russell RW, Goldstein JL, Brown MS, Sanchez-Pescador R, Bell GI (1985) Cassette of eight exons shared by genes for LDL receptor and EGF precursor. Science 228:893–895

    Article  PubMed  Google Scholar 

  • Tolleshavy H, Hobgood KK, Brown MS, Goldstein JL (1983) The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor. Cell 32:941–951

    Article  Google Scholar 

  • Turley SD, Dietschy JM (1982) Cholesterol metabolism and excretion. In: Arias I, Popper H, Schachter D, Shafritz DA (Hrsg) The Liver: Biology and Pathobiology. Raven Press, New York, S 467–492

    Google Scholar 

  • Utermann G, Jaeschke M, Menzel J (1975) Familial hyperlipoproteinemia type III: deficiency of a specific apolipoprotein (apo E-III) in the very-low-density lipoproteins. FEBS Lett 56:352–355

    Article  PubMed  CAS  Google Scholar 

  • Utermann G (1978) Genetik familiärer Hyperlipopidämien. Internist 19:465–469

    PubMed  CAS  Google Scholar 

  • Utermann G, Langenbeck U, Beisiegel U, Weber W (1980) Genetics of the apoprotein E system in man. Am J Hum Genet 32:339–347

    PubMed  CAS  Google Scholar 

  • Weisgraber KH, Rall SC, Mahley RW (1981) Human E apoprotein heterogenity. Cystein-arginine interchanges in the amino acid sequence of the apo E isoforms. J Biol Chem 256:9077–9083

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Schettler, G. (1986). Erhöhte Plasmalipide — ein Risikofaktor für die vorzeitige Arteriosklerose. In: Der Stoffwechsel der Plasmalipoproteine und seine Bedeutung für die Pathogenese der Arteriosklerose. Sitzungsberichte der Heidelberger Akademie der Wissenschaften, vol 1986 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46583-3_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-46583-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16583-5

  • Online ISBN: 978-3-642-46583-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics