Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 110)
Nucleotide Sequences of Adenovirus DNAs
The forty-odd identified human adenoviruses have been classified into groups A–G on the basis of DNA homology. After denaturation and renaturation of Ad DNA, single-stranded circles can be detected by electron microscopy, indicating that Ad DNA contains an inverted terminal repetition (ITR) of the type
5′ a b c ......c′ b′ a′
A number of these ITRs have been elucidated at the nucleotide level, belonging to human serotype groups A–E and also comprising sequences from simian, equine, canine, prosimian (tupaia), rodent (mouse) and avian adenoviruses (Table 1.1).
3′a′b′c′ ......c b a
KeywordsInverted Terminal Repetition Adenovirus Type Open Frame Adenovirus DNAs Unidentified Reading Frame
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Unable to display preview. Download preview PDF.
- Denisova TS, Makhov AM, Gibadulin RA (1982) Identification of simian adenovirus SA7P. Vopr Virusol N4: 483–488Google Scholar
- D’Halluin JC, Milleville M, Boulanger PA (1983) Restriction maps of human adenovirus types 2, 5 and 3 for Bell, Clal, Pvul and Sphl endonucleases. Gene 21: 171–173Google Scholar
- Kimura T, Sawada Y, Shinawawa M, Shimizu Y, Shiroki K, Shimojo H, Sugisaki H, Takanami M, Uemizu Y, Fujinaga K (1981) Nucleotide sequence of the transforming region Elb of adenovirus 12 DNA: structure and gene organization, and comparison with those of adenovirus type 5 DNA. Nuclei Acids Res 9: 6571–6589CrossRefGoogle Scholar
- Kruijer W (1983) Nucleotide sequence analysis of wild type and mutant genes encoding adenovirus DNA-binding protein: relation between structure and function of the protein. PhD Thesis, UtrechtGoogle Scholar
- Tooze J (1981) The molecular biology of tumor viruses. 2nd edn, part 2, DNA tumor viruses (revised). Cold Spring Harbor Laboratory, Cold Spring Harbor, NYGoogle Scholar
© Springer-Verlag Berlin · Heidelberg 1984