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Nucleotide Sequences of Adenovirus DNAs

  • H. van Ormondt
  • F. Galibert
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 110)

Abstract

The forty-odd identified human adenoviruses have been classified into groups A–G on the basis of DNA homology. After denaturation and renaturation of Ad DNA, single-stranded circles can be detected by electron microscopy, indicating that Ad DNA contains an inverted terminal repetition (ITR) of the type

5′ a b c ......c′ b′ a′

3′a′b′c′ ......c b a

A number of these ITRs have been elucidated at the nucleotide level, belonging to human serotype groups A–E and also comprising sequences from simian, equine, canine, prosimian (tupaia), rodent (mouse) and avian adenoviruses (Table 1.1).

Keywords

Inverted Terminal Repetition Adenovirus Type Open Frame Adenovirus DNAs Unidentified Reading Frame 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ahmed CMI, Chanda RS, Stow ND, Zain BS (1982a) The sequence of 3′ termini of mRNAs from early region III of adenovirus 2. Gene 19: 297–301PubMedCrossRefGoogle Scholar
  2. Ahmed CMI, Chanda RS, Stow ND, Zain BS (1982b) The nucleotide sequence of mRNA for the Mr 19,000 glycoprotein from early gene block III of adenovirus 2. Gene 20: 339–346PubMedCrossRefGoogle Scholar
  3. Akusjärvi G, Pettersson U (1978a) Sequence analysis of adenovirus DNA: I. Nucleotide sequence at the carboxy-terminal end of the gene for adenovirus type 2 hexon. Virology 91: 477–480PubMedCrossRefGoogle Scholar
  4. Akusjärvi G, Pettersson U (1978b) Nucleotide sequence at the junction between the coding region of the adenovirus 2 hexon messenger RNA and its leader sequence. Proc. Natl Acad Sci USA 75: 5822–5826PubMedCrossRefGoogle Scholar
  5. Akusjärvi G, Pettersson U (1979a) Sequence analysis of adenovirus DNA: complete nucleotide sequence of the spliced 5’ non-coding region of adenovirus 2 hexon messenger RNA. Cell 16: 841–850PubMedCrossRefGoogle Scholar
  6. Akusjärvi G, Pettersson U (1979b) Sequence analysis of adenovirus DNA. IV. The genomic sequences encoding the common tripartite leader of late adenovirus messenger RNA. J Mol Biol 134: 143–158PubMedCrossRefGoogle Scholar
  7. Akusjärvi G, Persson H (1981a) Gene and mRNA for precursor polypeptide VI from adenovirus type 2. J Virol 38: 469–482PubMedGoogle Scholar
  8. Akusjärvi G, Persson H (1981b) Controls of RNA splicing and termination in the major late adenovirus transcription unit. Nature 292: 420–426PubMedCrossRefGoogle Scholar
  9. Akusjärvi G, Mathews MB, Andersson P, Vennström B, Pettersson U (1980) Structure of genes for virus-associated RNA1 and RNA2 of adenovirus type 2. Proc Natl Acad Sci USA 77: 2424–2428PubMedCrossRefGoogle Scholar
  10. Akusjärvi G, Zabielski J, Perricaudet M, Pettersson U (1981) The sequence of the 3′ non-coding region of the hexon mRNA discloses a novel adenovirus gene. Nucleic Acids Res 9: 1–7PubMedCrossRefGoogle Scholar
  11. Aleström P, Akusjärvi G, Perricaudet M, Mathews MB, Klessig D, Pettersson U (1980) Sequence analysis of adenovirus DNA. VI. The nucleotide sequence of the gene for polypeptide IX from adenovirus type 2 and its unspliced messenger RNA. Cell 19: 671–681PubMedCrossRefGoogle Scholar
  12. Aleström, P, Stenlund A, Li P, Pettersson U (1982a) A common sequence in the inverted terminal repetitions of human and avian adenoviruses. Gene 18: 193–197PubMedCrossRefGoogle Scholar
  13. Aleström P, Akusjärvi G, Pettersson M, Pettersson U (1982b) DNA sequence analysis of the region encoding the terminal protein and the hypothetical N-gene product of adenovirus type 2. J Biol Chem 257: 13492–13498PubMedGoogle Scholar
  14. Arrand JR, Roberts RJ (1979) The nucleotide sequences at the termini of adenovirus-2 DNA. J Mol Biol 128: 577–594PubMedCrossRefGoogle Scholar
  15. Baker CC, Ziff EB (1980) Biogenesis, structures, and sites of encoding of the 5′ termini of adenovirus-2 mRNAs. Cold Spring Harbor Symp Quant Biol 44: 415–428PubMedCrossRefGoogle Scholar
  16. Baker CC, Ziff EB (1981) Promoters and heterogeneous 5’ termini of the messenger RNAs of adenovirus-2. J Mol Biol 149: 189–221PubMedCrossRefGoogle Scholar
  17. Baker CC, Hérissé J, Courtois G, Galibert F, Ziff E (1979) Messenger RNA for the Ad2 DNA binding protein: DNA sequences encoding the first leader and heterogeneity at the mRNA 5′ end. Cell 18: 569–580PubMedCrossRefGoogle Scholar
  18. Berk AJ, Sharp PA (1978) Structure of the adenovirus 2 early mRNAs. Cell 14: 695–711PubMedCrossRefGoogle Scholar
  19. Bos JL, Polder LJ, Bernards R, Schrier PI, van den Elsen PJ, van der Eb AJ, van Ormondt H (1981) The 2.2 kb Elb mRNA of human Ad12 and Ads codes for two tumor antigens starting at different AUG triplets. Cell 27: 121–131PubMedCrossRefGoogle Scholar
  20. Brinckmann U, Darai G, Flügel RM (1983) The nucleotide sequence of the inverted terminal repetition of the tree shrew adenovirus DNA. Gene 24: 131–135PubMedCrossRefGoogle Scholar
  21. Byrd PJ, Chia W, Rigby PWJ, Gallimore PH (1982) Cloning of DNA fragments from the left end of the adenovirus type 12 genome: transformation by cloned early region 1. J Gen Virol 60: 279–293PubMedCrossRefGoogle Scholar
  22. Chow LT, Broker TR, Lewis JB (1979) Complex splicing patterns of RNAs from the early regions of adenovirus 2. J Mol Biol 134: 265–303PubMedCrossRefGoogle Scholar
  23. Dekker BMM, van Ormondt H (1984) The nucleotide sequence of fragment HindIII-C of human adenovirus type 5 DNA (map positions 17.1–31.7) Gene 27: 115–120PubMedGoogle Scholar
  24. Denisova TS, Makhov AM, Gibadulin RA (1982) Identification of simian adenovirus SA7P. Vopr Virusol N4: 483–488Google Scholar
  25. D’Halluin JC, Milleville M, Boulanger PA (1983) Restriction maps of human adenovirus types 2, 5 and 3 for Bell, Clal, Pvul and Sphl endonucleases. Gene 21: 171–173Google Scholar
  26. Dijkema R, Dekker BMM (1979) The inverted terminal repetition of the DNA of weakly oncogenic adenovirus type 7. Gene 8: 7–15PubMedCrossRefGoogle Scholar
  27. Dijkema R, Dekker BMM, Van Ormondt H (1982) Gene organization of the transforming region of adenovirus type 7 DNA. Gene 18: 143–156PubMedCrossRefGoogle Scholar
  28. Engler JA, van Bree MP (1982) The nucleotide sequence of the gene encoding protein IVa2 in human adenovirus type 7. Gene 19: 71–80PubMedCrossRefGoogle Scholar
  29. Engler JA, Hoppe MS, van Bree MP (1983) The nucleotide sequence of the genes encoded in early region 2b of human adenovirus type 7. Gene 21: 145–159PubMedCrossRefGoogle Scholar
  30. Fowlkes DM, Shenk T (1980) Transcriptional control regions of the adenovirus VAI RNA gene. Cell 22: 405–423PubMedCrossRefGoogle Scholar
  31. Fraser N, Ziff E (1978) RNA structures near poly(A) of adenovirus-2 late messenger RNAs. J Mol Biol 124: 27–51PubMedCrossRefGoogle Scholar
  32. Friefeld BR, Lichy JH, Hurwitz J, Horwitz MS (1983) Evidence for an altered adenovirus DNA polymerase in cells infected with the mutant H5ts149. Proc Natl Acad Sci USA 80: 1589–1593PubMedCrossRefGoogle Scholar
  33. Galibert F, Hérissé J, Courtois G (1979) Nucleotide sequence of the EcoRI-F fragment of adenovirus 2 genome. Gene 6: 1–22PubMedCrossRefGoogle Scholar
  34. Garon CF, Parr RP, Padmanabhan R, Roninson I, Garrison JW, Rose JA (1982) Structural characterization of the adenovirus 18 inverted terminal repetition. Virology 121: 230–239PubMedCrossRefGoogle Scholar
  35. Gingeras TR, Sciaky D, Gelinas RE, Bing-Dong J, Yen CE, Kelly MM, Bullock PA, Parsons B, O’Neill KE, Roberts RJ (1982) Nucleotide sequences from the adenovirus genome J Biol Chem 257: 13475–13491PubMedGoogle Scholar
  36. Hérissé J, Courtois G, Galibert F (1980) Nucleotide sequence of the EcoRI D fragment adenovirus 2 genome. Nucleic Acids Res 8: 2173–2192PubMedCrossRefGoogle Scholar
  37. Hérissé J, Galibert F (1981a) Nucleotide sequence of the EcoRI E fragment of adenovirus 2 genome. Nucleic Acids Res 9: 1229–1240PubMedCrossRefGoogle Scholar
  38. Hérissé J, Rigolet M, Dupont de Dinechin S, Galibert F (1981b) Nucleotide sequence of adenovirus 2 DNA fragment encoding for the carboxylic region of the fiber protein and the entire E4 region. Nucleic Acids Res 9:4023–4042PubMedCrossRefGoogle Scholar
  39. Jörnvall H, Aleström P, Akusjärvi G, von Bahr-Lindström H, Philipson L, Pettersson U (1981) Order of the CNBr fragments in the adenovirus hexon protein. J Biol Chem 256: 6204–6212PubMedGoogle Scholar
  40. Kimura T, Sawada Y, Shinawawa M, Shimizu Y, Shiroki K, Shimojo H, Sugisaki H, Takanami M, Uemizu Y, Fujinaga K (1981) Nucleotide sequence of the transforming region Elb of adenovirus 12 DNA: structure and gene organization, and comparison with those of adenovirus type 5 DNA. Nuclei Acids Res 9: 6571–6589CrossRefGoogle Scholar
  41. Kruijer W (1983) Nucleotide sequence analysis of wild type and mutant genes encoding adenovirus DNA-binding protein: relation between structure and function of the protein. PhD Thesis, UtrechtGoogle Scholar
  42. Kruijer W, van Schaik FMA, Sussenbach JS (1980) Nucleotide sequence of a region of adenovirus 5 DNA encoding a hitherto unidentified gene. Nucleic Acids Res 8: 6033–6042PubMedCrossRefGoogle Scholar
  43. Kruijer W, van Schaik FMA, Sussenbach JS (1981) Structure and organization of the gene coding for the DNA binding protein of adenovirus type 5. Nucleic Acids Res 9: 4439–4457PubMedCrossRefGoogle Scholar
  44. Kruijer W, van Schaik FMA, Sussenbach JS (1982) Nucleotide sequence of the gene encoding adenovirus type 2 DNA binding protein. Nucleic Acids Res 10: 4493–4500PubMedCrossRefGoogle Scholar
  45. Kruijer W, van Schaik FMA, Speijer JG, Sussenbach JS (1983) Structure and function of adenovirus DNA binding protein: comparison of the amino acid sequences of the Ads and Ad12 proteins derived from nucleotide sequence of the corresponding genes. Virology 128: 140–153PubMedCrossRefGoogle Scholar
  46. Maat J, van Ormondt H (1979) The nucleotide sequence of the transforming HindIII-G fragment of adenovirus type 5 DNA. Gene 6: 75–90PubMedCrossRefGoogle Scholar
  47. Oosterom-Dragon EA, Anderson CW (1983) Polypeptide structure and encoding location of the adenovirus serotype 2 late, non-structural 33K protein. J Virol 45: 251–263PubMedGoogle Scholar
  48. Perricaudet M, Akusjärvi G, Virtanen A, Pettersson U (1979) Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses. Nature 281: 694–696PubMedCrossRefGoogle Scholar
  49. Perricaudet M, Le Moullec JM, Pettersson U (1980a) The predicted structure of two adenovirus T antigens. Proc Natl Acad Sci USA 77: 3778–3782PubMedCrossRefGoogle Scholar
  50. Perricaudet M, Le Moullec JM, Tiollais P, Pettersson U (1980b) Structure of two adenovirus type 12 transforming polypeptides and their evolutionary implications. Nature 288: 174–176PubMedCrossRefGoogle Scholar
  51. Persson H, Mathisen B, Philipson L, Pettersson U (1979) A maturation protein in adenovirus morphogenesis. Virology 93: 198–208PubMedCrossRefGoogle Scholar
  52. Persson H, Jörnvall H, Zabielski J (1980) Multiple RNA species for the precursor to an adenovirus encoded glycoprotein: identification and structure of the signal sequence. Proc Nati Acad Sci USA 77: 6349–6353CrossRefGoogle Scholar
  53. Shinagawa M, Padmanabhan R (1979) Nucleotide sequence at the inverted repetition of adenovirus type 2 DNA. Biochem Biophys Res Commun 87: 671–678PubMedCrossRefGoogle Scholar
  54. Shinagawa M, Padmanabhan R (1980) Comparative sequence analysis of the inverted terminal repetitions from different adenoviruses. Proc Natl Acad Sci USA 77: 3831–3835PubMedCrossRefGoogle Scholar
  55. Shinagawa M, Padmanabhan RV, Padmanabhan R (1980) The nucleotide sequence of the right-hand terminal Smal-K fragment of adenovirus type 2 DNA. Gene 9: 99–114PubMedCrossRefGoogle Scholar
  56. Shinagawa M, Ishiyama T, Padmanabhan R, Fujinaga K, Kamada M, Sato G (1983) Comparative sequence analysis of the inverted terminal repetition in the genomes of animal and avian adenoviruses. Virology 125: 491–495PubMedCrossRefGoogle Scholar
  57. Smart JE, Stillman BW (1982) Adenovirus terminal protein precursor. Partial amino acid sequence and the site of covalent linkage to virus DNA. J Biol Chem 257: 13499–12506PubMedGoogle Scholar
  58. Stâlhandske P, Persson H, Perricaudet M, Philipson L, Pettersson U (1983) Structure of three spliced mRNAs from region E3 of adenovirus type 2. Gene 22: 157–165PubMedCrossRefGoogle Scholar
  59. Steenbergh PH, Sussenbach JS (1979) The nucleotide sequence of the right-hand terminus of adenovirus type 5 DNA: implications for the mechanism of DNA replication. Gene 6: 307–318PubMedCrossRefGoogle Scholar
  60. Stetenbergh PH, Maat J, van Ormondt H, Sussenbach JS (1977) The nucleotide sequence at the termini of adenovirus type DNA. Nucleic Acids Res 4: 4371–4389CrossRefGoogle Scholar
  61. Stillman BW, Topp WC, Engler JA (1982) Conserved sequences at the origin of adenovirus DNA replication. J Virol 44: 530–537PubMedGoogle Scholar
  62. Sugisaki H, Sugimoto K, Takanami M, Shiroki K, Saito I, Shimojo H, Sawada Y, Uemizu Y, Uesugi S, Fujinaga K (1980) Structure and gene organization in the transforming HindIII-G fragment of Ad12. Cell 20: 777–786PubMedCrossRefGoogle Scholar
  63. Sung MT, Cao TM, Coleman RT, Budelier KA (1983) Gene and protein sequences of adenovirus protein VII, a hybrid basic chromosomal protein. Proc Natl Acad Sci USA 80: 2902–2906PubMedCrossRefGoogle Scholar
  64. Temple M, Antoine G, Delius H, Stahl S, Winnacker EL (1981) Replication of mouse adenovirus strain FL DNA. Virology 109: 1–12PubMedCrossRefGoogle Scholar
  65. Tolun A, Aleström P, Pettersson U (1979) Sequence of inverted terminal repetitions from different adenoviruses: demonstration of conserved sequences and homology between SA7 termini and SV40 DNA. Cell 17: 705–713PubMedCrossRefGoogle Scholar
  66. Tooze J (1981) The molecular biology of tumor viruses. 2nd edn, part 2, DNA tumor viruses (revised). Cold Spring Harbor Laboratory, Cold Spring Harbor, NYGoogle Scholar
  67. van Beveren CP, Maat J, Dekker BMM, van Ormondt H (1981) The nucleotide sequence of the gene for protein IVa2 and of the 5’ leader segment of the major late mRNAs of adenovirus type 5. Gene 16: 179–189PubMedCrossRefGoogle Scholar
  68. van Ormondt H, Hesper B (1983) Comparison of the nucleotide sequences of early region Elb DNA of adenovirus types 12, 7 and 5 (subgroups A, B and C ). Gene 21: 217–226PubMedCrossRefGoogle Scholar
  69. van Ormondt H, Maat J, Dijkema R (1980a) Comparison of nucleotide sequences of the early Ela regions for subgroups A, B and C of human adenoviruses. Gene 12: 63–76PubMedCrossRefGoogle Scholar
  70. van Ormondt H, Maat J, van Beveren CP (1980b) The nucleotide sequence of the transforming early region El of adenovirus type 5 DNA. Gene 11: 299–309PubMedCrossRefGoogle Scholar
  71. Virtanen A, Pettersson U (1983) The molecular structure of the 9S mRNAs from early region 1 A of adenovirus serotype 2. J Mol Biol 165: 496–99PubMedCrossRefGoogle Scholar
  72. Virtanen A, Aleström P, Persson H, Katze MG, Pettersson U (1982a) An adenovirus agnogene. Nucleic Acids Res 10: 2539–2548PubMedCrossRefGoogle Scholar
  73. Virtanen A, Pettersson U, Perricaudet M, Le Moullec JM, Tiollais P, Perricaudet M (1982b) Different mRNA from the transforming region of highly oncogenic and non-oncogenic human adenoviruses. Nature 295: 705–707PubMedCrossRefGoogle Scholar
  74. Zain S, Roberts RJ (1979) Sequences from the beginning of the fiber messenger RNA of adenovirus 2. J Mol Biol 131: 341–352PubMedCrossRefGoogle Scholar
  75. Zain S, Sambrook J, Roberts RJ, Keller W, Fried M, Dunn AR (1979) Nucleotide sequence analysis of the leader segments in a cloned copy of adenovirus 2 fiber mRNA. Cell 16: 851–861PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • H. van Ormondt
    • 1
  • F. Galibert
    • 2
  1. 1.Department of Medical BiochemistryUniversity of LeidenLeidenThe Netherlands
  2. 2.Laboratory of Experimental Hematology, Centre HayemHôpital St. LouisParisFrance

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