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Transformation and Oncogenicity by Adenoviruses

  • Chapter
The Molecular Biology of Adenoviruses 2

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 110))

Abstract

Adenoviruses have attracted considerable attention since it was discovered by Trentin et al. (1962) and Huebner et al. (1962) that certain species (formerly called serotypes; Wigand et al. 1982) are oncogenic when injected into newborn hamsters. Since then, adenoviruses have been used extensively as a model for studies on tumor induction in vivo and cell transformation in vitro. Together with the small papovaviruses, they have played an important role in fundamental cancer research and have provided invaluable tools for studies on the organization and expression of eukaryotic genes. The introduction of new techniques of DNA sequencing, molecular cloning, and DNA transfection in the past few years have further contributed to a rapid development of adenovirus research in all its diverse aspects.

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  1. Department of Medical Biochemistry, Sylvius Laboratories, Wassenaarseweg 72, NL-2333 AL, Leiden, The Netherlands

    A. J. van der Eb & R. Bernards

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  1. A. J. van der Eb
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  2. R. Bernards
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  1. Institut für Genetik, Universität zu Köln, Weyertal 121, D-5000, Köln 41, Germany

    Walter Doerfler

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van der Eb, A.J., Bernards, R. (1984). Transformation and Oncogenicity by Adenoviruses. In: Doerfler, W. (eds) The Molecular Biology of Adenoviruses 2. Current Topics in Microbiology and Immunology, vol 110. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46494-2_2

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  • DOI: https://doi.org/10.1007/978-3-642-46494-2_2

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