Abstract
Quinine is the oldest chemotherapeutic drug still in use. The first recorded medical application of an infusion of the bark of the cinchona tree dates back to 1630 when Don Juan López de Cannizares was treated in Peru for an intermittent fever. Don Juan recommended the medication to the viceroy for the treatment of his wife, the Condesa de Chinchón. By 1639 the cinchona bark had reached Europe and became known as Jesuits’ powder.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ainley, A.D., King, H.: Antiplasmodial action and chemical constitution. II. Some simple synthetic analogs of quinine and cinchonine. Proc. R. Soc. B 125, 60–92 (1938)
Allison, R.G., Hahn, F.E.: Changes in superhelical density of closed circular deoxyribonucleic acid by intercalation of anti-R-plasmid drugs and primaquine. Antimicrob. Agents Chemother. 11, 251–257 (1977)
Andersag, H., Breitner, S., Jung, H.: Verfahren zur Darstellung von in 4-Stellung basisch substituierte Aminogruppen enthaltenden Chinolinverbindungen. Ger. Pat. 683–692 (1939)
Cavanaugh, M.W., Cavanaugh, D.J.: Studies on the pharmacology of tissue cultures. I. The action of quinidine on cultures of dissociated chick-embryo heart cells. Arch. Int. Pharmacodyn. 110, 43–55 (1957)
Chargaff, E.: Isolation and composition of the deoxypentose nucleic acids and of the corresponding nucleoproteins. In: The nucleic acids. Chargaff E., Davidson, J.N. (eds.), Vol.I. New York: Academic Press 1955
Clancy, C.F.: The lethal effect of certain antimalarial drugs on Tetrahymena pyriformis. Am. J. Trop. Med. Hyg. 17, 359–363 (1968)
Clarke, D.H.: The use of phosphorus 32 in studies on Plasmodium gallinaceum. II. Studies on conditions affecting parasite growth in intact cells and in lysates. J. Exp. Med. 96, 451–463 (1952)
Cohen, A., King, H.: Antiplasmodial action and chemical constitution. I. Cinchona alkaloidal derivatives and allied substances. Proc. R. Soc. B 125, 49–60 (1938)
Conklin, K.A., Chou, S.C.: The effects of antimalarial drugs on uptake and incorporation of macromolecular precursors by Tetrahymena pyriformis. J. Pharmacol. Exp. Ther. 180, 158–166 (1972)
Conklin, K.A., Chou, S.C., Ramanathan, S.: Quinine: Effect on Tetrahymena pyriformis. I. Inhibition of synchronized cell division and site of action. Pharmacology 2, 247–256 (1969)
Dyke, K., van, Szustkiewicz, C., Lantz, C.H., Saxe, L.H.: Studies concerning the mechanism of action of antimalarial drugs — Inhibition of the incorporation of adenosine-8-3H into nucleic acids of Plasmodium berghei. Biochem. Pharmacol. 18, 1417–1425 (1969)
Estensen, R.D., Krey, A.K., Hahn, F.E.: Studies on a deoxyribonucleic acid-quinine complex. Mol. Pharmacol. 5, 532–541 (1969)
Findlay, G.M.: Toxic reactions to antimalarial drugs. Recent Adv. Chemother. 2, 187–269 (1951)
Foley, G.E., McCarthy, R.E., Binns, V.M., Snell, E.E., Girard, B.M., Kidder, G.W., Dewey, V.C., Theyer, P.S.: A comparative study of the use of microorganisms in the screening of potential antitumor agents. Ann. N.Y. Acad. Sci. 76, 413–441 (1959)
Gerberg, E.J.: Evaluation of antimalarial compounds in mosquito test systems. Trans. R. Soc. Trop. Med. Hyg. 65, 358–363 (1971)
Hahn, F.E.: Structure-activity rules and the receptor hypothesis. Top. Infect. Dis. 1, 3–14 (1975)
Hahn, F.E., Ciak, J.: Elimination of bacterial episomes by DNA-complexing compounds. Ann. N.Y. Acad. Sci. 182, 295–304 (1971)
Hahn, F.E., Ciak, J.: Elimination of resistance determinants from R-factor R1 by intercalative compounds. Antimicrob. Agents Chemother. 9, 77–80 (1976)
Hahn,F.E., Krey, A.K.: Interaction of alkaloids with DNA. Prog. Mol. Subcell. Biol. 2,134–151 (1971)
Hahn, F.E., O’Brien, R.L., Ciak, J., Allison, J.L., Olenick, J.G.: Studies on modes of action of chloroquine, quinacrine and quinine and on chloroquine resistance. Mil. Med. 131,1071–1089(1966)
Hill. J.: The schizontocidal effect of some antimalarials against Plasmodium berghei. Ann. Trop. Med. Parasitol. 44, 291–297 (1950)
King, H., Work, T.S.: Antiplasmodial action and chemical constitution. V. Carbinolamines derived from 6-methoxyquinoline. J. Chem. Soc. 1942, 401–404
Krey, A.K., Hahn, F.E.: Studies on the methyl green-DNA complex and its dissociation by drugs. Biochemistry 14, 5061–5067 (1975)
Lambin, S., Bernard, J.: Sur les modalités d’action des substances alcaloîdiques. C. R. Soc. Biol. 149, 492–495 (1955)
Lantz, C.H., Van Dyke, K.: Studies concerning the mechanism of action of antimalarial drugs — II. Inhibition of the incorporation of adenosine-5′-monophosphate-3H into nucleic acids of erythrocyte-free malarial parasites. Biochem. Pharmacol. 20, 1157–1166 (1971)
O’Brien, R.L., Olenick, J.G., Hahn, F.E.: Reactions of quinine, chloroquine and quinacrine with DNA and their effects on the DNA and RNA polymerase reactions. Proc. Natl. Acad. Sci. USA 55, 1511–1517(1966)
Peters, W.: Chemotherapy and drug resistance in malaria. New York: Academic Press 1970
Pinder, R.M.: Antimalarials. In: Medicinal chemistry, 3rd ed. Parti. Burger, A. (ed.) New York Wiley & Sons 1970
Polet, H., Barr, C.F.: Chloroquine and dihydroquinine. In vitro studies of their antimalarial effect upon Plasmodium knowlesi. J. Pharmacol. Exp. Ther. 164, 380–386 (1968)
Powell, R.D., Tigertt, W.D.: Drug resistance of parasites causing human malaria. Ann. Rev. Med. 19, 81–102 (1968)
Priselkov, M.M., Samsonova, M.N., Pushkar, E.G.: Utilization of quinine and ditaine by microorganisms for biochemical purposes. Aptechn. Delo 7, 32 (1958), through Chem. Abstr. 54, 1655 (1960)
Romanovsky, D.L.: Specific action of quinine in malaria. Vrach (St. Petersburg) 12, 438–440 (1891), through Zbl. Bakteriol. Parasitenkd. 11, 219 (1892)
Schellenberg, K.A., Coatney, G.R.: The influence of antimalarial drugs on nucleic acid synthesis in Plasmodium gallinaceum and Plasmodium berghei. Biochem. Pharmacol. 6, 143–152 (1961)
Schulemann, W.: Synthetic anti-malarial preparations. Proc. R. Soc. Med. 25, 897–905 (1932)
Silverman, M.: Metal antagonism of the antibacterial action of atabrine and other drugs. Arch. Biochem. 19, 193–198 (1948)
Stollar, D., Grossman, L.: The reaction of formaldehyde with denatured DNA: spectrophotometric, immunologie and enzymic studies. J. Mol. Biol. 4, 31–38 (1962)
Tigertt, W.D., Clyde, D.F.: Drug resistance in the human malarias. In: Acquired resistance of microorganisms to chemotherapeutic drugs. Antibiotics and chemotherapy. Hahn, F.E. (ed.), Vol. 20, pp. 246–272. Basel: Karger 1976
Turner, R.B., Woodward, R.B.: The chemistry of the cinchona alkaloids. In: The alkaloids, chemistry and physiology III. p. 1 New York: Academic Press 1953
Walsh, C.J., Sherman, I.W.: Isolation, characterization and synthesis of DNA from a malaria parasite. J. Protozool. 15, 503–508 (1968)
Waring, M.: Variations of the supercoils in closed circular DNA by binding of antibiotics and drugs: evidence for molecular models involving intercalation. J. Mol. Biol. 54, 247–279 (1970)
Wiselogle, F.Y. (ed.): A survey of antimalarial drugs 1941–1945. Vol. I, p. 142. Ann Arbor: J.W. Edwards 1946
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Hahn, F.E. (1979). Quinine. In: Hahn, F.E. (eds) Mechanism of Action of Antieukaryotic and Antiviral Compounds. Antibiotics, vol 5 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46407-2_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-46407-2_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-46409-6
Online ISBN: 978-3-642-46407-2
eBook Packages: Springer Book Archive