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Tiamulin and Pleuromutilin

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Mechanism of Action of Antibacterial Agents

Part of the book series: Antibiotics ((1512,volume 5 / 1))

Abstract

In 1951 Kavanagh isolated from two basidiomycetes species, Pleurotus mutilus (Fr.) Sacc. and Pleurotus Passeckerianus Pilat, a substance which showed antibacterial activity. Kavanagh et al. (1951) named the crystalline material pleuromutilin. The antibacterial activity of this compound was modest and its spectrum largely confined to gram-positive organisms. Kavanagh and coworkers proposed for pleuromutilin the empirical formula C22H34O5; this was confirmed by subsequent chemical work. After a decade, the structural formula of this antibiotic was elucidated by both Arigoni’s group in Zürich (Naegeli, 1961; Arigoni, 1962) and by Birch and co-workers in Manchester (Birch etal., 1963; Birch etal., 1966). The sterochemical details of Formula I were established by Bonavia (1968) on the basis of X-ray and ORD data.

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Authors
  1. G. Högenauer
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Editors and Affiliations

  1. Department of the Army, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington D.C., 20012, USA

    Fred E. Hahn Ph.D.

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Högenauer, G. (1979). Tiamulin and Pleuromutilin. In: Hahn, F.E. (eds) Mechanism of Action of Antibacterial Agents. Antibiotics, vol 5 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46403-4_19

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  • DOI: https://doi.org/10.1007/978-3-642-46403-4_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46405-8

  • Online ISBN: 978-3-642-46403-4

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