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Speculations on the Role of Major Transplantation Antigens in Cell-Mediated Immunity Against Intracellular Parasites

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Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 82))

Abstract

In three major fields of immunology—“academic” immunology, immunology of infectious diseases, and transplantation immunology—exciting features in common have been discovered over the past few years. As early as the 1950’s, possible links between the transplantation reaction and cell-mediated immunity to cell-bound antigens or intracellular parasites were postulated. For instance, Mitchison speculated that cellular immune recognition of antigen in delayed-type hypersensitivity (DTH) reactions probably occurred only when the antigen involved (e.g., tuberculin or chemical allergens) were present on the cell-membrane, thus resembling a foreign transplantation antigen (Mitchison, 1954). Lawrence, stimulated by Thomas’ surveillance hypothesis (Thomas, 1959), proposed that immune lymphocytes recognize not only foreign antigens on cell surfaces, since cell-mediated immunity originally evolved against intracellular parasites, but also recognized a self-component (Lawrence, 1959, 1974). This self-plus-X hypothesis was a very lucid speculation that foresaw many of the principles discovered since. All these discoveries now lead to the conclusion that thymus-derived lymphocytes (T-cells) seem to express a double specificity for foreign antigenic determinants and for cell-surface self determinants (For reviews see Paul and Benacerraf, 1977; Munro and Bright, 1976; Doherty et al., 1976; Shearer et al., 1976; Forman, 1976; Zinkernagel and Doherty, 1977a; Koszinowski et al., 1977a; Schrader et al., 1977; Katz, 1977; Langman, 1978).

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Abbreviations

Ag-B:

Major rat histocompatibility

CMI:

Cell-mediated immunity

DTH:

Delayed-type hypersensitivity

H:

Major histocompatibility

H-2:

Major murine histocompatibility

HL-A:

Major human histocompatibility

Ir:

Immune response

P:

Parental

T:

Thymus derived

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  1. The Department of Cellular and Developmental Immunology, Research Institute of Scripps Clinic, La Jolla, California, 92037, USA

    Rolf M. Zinkernagel

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  11. Los Angeles, USA

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Zinkernagel, R.M. (1978). Speculations on the Role of Major Transplantation Antigens in Cell-Mediated Immunity Against Intracellular Parasites. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 82. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46388-4_4

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