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Pharmacokinetic Drug Interactions

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Concepts in Biochemical Pharmacology

Abstract

Drugs may frequently interact adversely to cause drug toxicity or render a needed therapy ineffective. The situation is compounded by the current pattern of drug usage in which approximately ten different drugs are received by the average patient in the hospital. The number of drugs employed in combination in the out-patient setting is also increasing as more chronic diseases are treated for longer periods of time. In this therapeutic milieu, surveys of drug usage have shown that more than 10% of patients were concomitantly receiving drugs considered to interact adversely with one another. This suggests a need not only for an improved awareness of drug interactions by physicians but also for careful investigative documentation of drug interactions and their clinical relevance in man in order to provide a rational education in this important aspect of therapeutics. Mere proliferation of lists containing numerous speculative and inadequately documented drug interactions is educationally counter-productive, serving only to destroy credibility and to cause many physicians to shrug off drug interactions as hobgoblins from the pharmacologist’s imagination.

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  1. D. G. Shand
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  1. Laboratory of Chemical Pharmacology, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland, 20014, USA

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Shand, D.G., Mitchell, J.R., Oates, J.A. (1975). Pharmacokinetic Drug Interactions. In: Gillette, J.R., Mitchell, J.R. (eds) Concepts in Biochemical Pharmacology. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 28 / 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46314-3_11

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