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Mechanism of Action of Antimicrobial and Antitumor Agents pp 668–698Cite as

Sulfonamides and Sulfones

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Part of the book series: Antibiotics ((ANTIBIOTICS,volume 3))

Abstract

The discovery of the antibacterial activity of sulfonamides1 in 1930’s marked the beginning of the era of modern antibacterial drug research. Subsequent observation of variations in the activities of these compounds by structural changes brought into sharp focus the power of molecular modification in drug development. The elucidation of the relationship between sulfanilamide and p-aminobenzoic acid provided one long sought-after mechanistic basis for a biochemical approach to chemotherapy. Much of the subsequent work in chemotherapy, and drug research in general, has been based on consideration of these facts.

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  1. Nitya Anand
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  1. Department of Biochemistry, The Medical and Dental Schools, Northwestern University, 303 E. Chicago Avenue, Chicago, Illinois, 60611, USA

    John W. Corcoran Ph.D.

  2. Department of the Army, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C., 20012, USA

    Fred E. Hahn Ph.D.

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Anand, N. (1975). Sulfonamides and Sulfones. In: Corcoran, J.W., Hahn, F.E., Snell, J.F., Arora, K.L. (eds) Mechanism of Action of Antimicrobial and Antitumor Agents. Antibiotics, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46304-4_45

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