Abstract
Streptomycin was isolated from Streptomyces griseus by SCHATZ et al. in 1944 and was the first nontoxic broad spectrum antibiotic discovered which was also effective against the tubercle bacillus. The chemical structure is N-methyl-L-glucosaminidostreptoside-streptidine and the antibiotic is a highly polar organic base with a large number of hydrophilic and functional groups (Fig. 1).
Supported in part by grants CA 12021 from the P. H. S., GB 23052 from the NSF and a grant from the John A. Hartford Foundation, Inc.
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Schlessinger, D., Medoff, G. (1975). Streptomycin, Dihydrostreptomycin, and the Gentamicins. In: Corcoran, J.W., Hahn, F.E., Snell, J.F., Arora, K.L. (eds) Mechanism of Action of Antimicrobial and Antitumor Agents. Antibiotics, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46304-4_36
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