Abstract
One of the goals of the scientist who works with antibiotics is to evolve tailor-made molecules to combat infectious diseases. Thus far, this goal has not been advanced much beyond the stage of modifying some chemical groups in naturally occurring antibiotic molecules (Coghill et al., 1949). Another avenue that might lead to the same goal could be the screening of known chemicals for antimicrobial action.
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References
Battaner, E., and D. Vazquez: Inhibitors of protein synthesis by ribosomes of the 80-S type. Biochim. Biophys. Acta 254, 316 (1971).
Cavalli, L. L., and G. A. Maccacaro: Polygenic inheritance of drug-resistance in the bacterium, Escherichia coli. Heredity 6, 311 (1952).
Coghill, R. D., F. H. Stodola, and J. L. Wachtel: Chemical modifications of natural penicillins. In: The Chemistry of Penicillin, H.T. Clarke, J. R. Johnson, and R. Robinson, eds. p. 680. Princeton, N.J.: Princeton University Press 1949.
Grollman, A. P.: Inhibition of messenger ribonucleic acid attachment to ribosomes. II. Proposed mechanism for the design of novel antiviral agents. Antimicrobial Agents and Chemotherapy 1968. American Society for Microbiology. G. L. Hobby, ed. p. 36.
Grollman, A. P., and M. L. Stewart: Inhibition of the attachment of messenger ribonucleic acid to ribosomes. Proc. Natl. Acad. Sci. U.S. 61, 719 (1968).
Hsu, W.T.: Translation of an RNA viral message in vitro; one-step polypeptide chain elongation. Biochem. Biophys. Res. Commun. 42, 405 (1971).
Huang, M. T., and A. P. Grollman: Effects of aurintricarboxylic acid on ribosomes and the biosynthesis of globin in rabbit reticulocytes. Mol. Pharm. 8, 111 (1972).
Joklik, W. K., and T. C. Merigan: Concerning the Mechanism of action of interferon. Proc. Natl. Acad. Sci. U.S. 56, 558 (1966).
Leader, D. P.: Aurintricarboxylic acid inhibition of the binding of phenyl-alanyl-tRNA to rat liver ribosomal subunits. FEBS Letters 22, 245 (1972).
Lebleu, B., G. Marbaix, J. Wérenne, A. Burny, and G. Huez: Effect of aurintricarboxylic acid and of NaF on the binding of globin messenger RNA to reticulocyte 40S ribosomal subunits. Biochem. Biophys. Res. Commun. 40, 731 (1970).
Levy, H. B., and W. A. Carter: Molecular basis of the action of interferon. J. Mol. Biol. 31, 561 (1968).
Lindenbaum, A., and J. Schubert: Binding of organic anions by serum albumin. J. Phys. Chem. 60, 1663 (1956).
Lindenbaum, A., M. R. White, and J. Schubert: Effect of aurintricarboxylic acid on beryllium inhibition of alkaline phosphatase. J. Biol. Chem. 196, 273 (1952).
Lund, E., and N. O. Kjeldgaard: Metabolism of guanosine tetraphosphate in E. coli. Eur. J. Biochem. 28, 316 (1972).
Marcus, A., J. D. Bewley, and D. P. Weeks: Aurintricarboxylic acid and initiation factors of wheat embryo. Science 167, 1735 (1970).
Marcus, P. I., and J. M. Salb: Molecular basis of interferon action: Inhibition of viral RNA translation. Virology 30, 502 (1966).
Mathews, M. B.: Mammalian chain initiation: the effect of aurintricarboxylic acid. FEBS letters 15, 201 (1971).
Pestka, S.: Translocation, aminoacyl-oligonucleotides, and antibiotic action. Cold Spring Harbor Symp. Quant. Biol. 34, 395 (1969 a).
Pestka, S.: Studies on the formation of transfer ribonucleic acid-ribosome complexes, XI. Antibiotic effects on phenylalanyl-oligonucleotide binding to ribosomes. Proc. Natl. Acad. Sci. U.S. 64, 709 (1969 b).
Pestka, S.: Inhibitors of ribosome function. Ann. Rev. Microbiol. 25, 487 (1971).
Roberts, W. K., and W. H. Coleman: Polyuridylic acid binding by protein from Ehrlich ascites cell ribosomes and its inhibition by aurintricarboxylic acid. Biochemistry 10, 4304 (1971).
Schubert, J., and A. Lindenbaum: Studies on the mechanism of protection by aurintricarboxylic acid in beryllium poisoning. II. Equilibria involving alkaline phosphatase. J. Biol. Chem. 208, 359 (1954).
Siegelman, F. L., and D. Apirion: Inhibition of polyuridylic acid-directed protein synthesis by aurintricarboxylate in extracts of Escherichia coli. J. Bacteriol. 105, 451 (1971 a).
Siegelman, F. L., and D. Apirion: Aurintricarboxylic acid, a perferential inhibitor of protein synthesis. J. Bacteriol. 105, 902 (1971 b).
Stewart, M. L., A. P. Grollman, and M. T. Huang: Aurintricarboxylic acid: inhibitor of initiation of protein synthesis. Proc. Natl. Acad. Sci. U.S. 68, 97 (1971).
Tal, M., M. Aviram, A. Kanarek, and A. Weiss: Polyuridylic acid binding and translating by Escherichia coli ribosomes: stimulation by protein I, inhibition by aurintricarboxylic acid. Biochim. Biophys. Acta 281, 381 (1972).
Wang, C. S., R. B. Naso, and R. B. Arlinghaus: Factor dependent binding of Rauscher leukemia virus RNA to ribosomes. Biochem. Biophys. Res. Commun. 47, 1290 (1972).
Weissbach, H., and N. Brot: Inhibition of transfer factor Ts by aurintricarboxylic acid. Biochem. Biophys. Res. Commun. 39, 1194 (1970).
Wilhelm, J. M., and R. Haselkorn: The chain growth rate of T4 lysozyme in vitro. Proc. Natl. Acad. Sci. U.S. 65, 388 (1970).
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Apirion, D., Dohner, D. (1975). Aurintricarboxylic Acid a Non-Antibiotic Organic Molecule that Inhibits Protein Synthesis. In: Corcoran, J.W., Hahn, F.E., Snell, J.F., Arora, K.L. (eds) Mechanism of Action of Antimicrobial and Antitumor Agents. Antibiotics, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46304-4_22
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DOI: https://doi.org/10.1007/978-3-642-46304-4_22
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