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Consideration of the Cell Cycle in Chemotherapy of Acute Leukemia

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Book cover Current Concepts in the Management of Lymphoma and Leukemia

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 36))

Abstract

There is now convincing evidence that it is possible to regularly cure certain experimental leukemias by using chemotherapeutic schedules specifically designed to exploit known information about the kinetic behavior of the leukemic cells, whereas other treatment schedules employing the same or higher total doses of the same drugs fail to effect any cures [1–9]. Much greater difficulty is encountered in treating spontaneous animal leukemias and human leukemia effectively, and the present paper is concerned with what we believe are the main reasons for these different results. To help focus attention on some of the critical points, two representative studies in patients with acute leukemia will be described for illustrative purposes, and general conclusions drawn from these studies in the context of previous information.

This investigation was supported in part by research grants CA-05826 and CA-08748 from the National Cancer Institute, United States Public Health Service, the American Cancer Society, T-538A, The John C. McCarroll Memorial Fund, Hearst Foundation Fund, United Leukemia Fund, and the Junior Committee of the Society of Memorial Sloan-Kettering Cancer Center.

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Author information

Authors and Affiliations

  1. Divisions of Chemotherapy Research, Sloan-Kettering Institute for Cancer Research, USA

    Bayard Clarkson, Akio Todo, Makoto Ogawa, Timothy Gee & Jerrold Fried

  2. Divisions of Biophysics, Sloan-Kettering Institute for Cancer Research, USA

    Bayard Clarkson, Akio Todo, Makoto Ogawa, Timothy Gee & Jerrold Fried

  3. Department of Medicine, Memorial Hospital for Cancer and Allied Diseases, New York, N. Y., USA

    Bayard Clarkson, Akio Todo, Makoto Ogawa, Timothy Gee & Jerrold Fried

Authors
  1. Bayard Clarkson
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  2. Akio Todo
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  3. Makoto Ogawa
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  4. Timothy Gee
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  5. Jerrold Fried
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Editor information

Editors and Affiliations

  1. Department of Medicine, University of Chicago, Chicago, IL, USA

    John E. Ultmann M.D.

  2. Department of Radiology, University of Chicago, Chicago, IL, USA

    Melvin L. Griem

  3. Department of Pathology, University of Chicago, Chicago, IL, USA

    Robert W. Wissler Ph.D., M.D.

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© 1971 Springer-Verlag Berlin · Heidelberg

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Clarkson, B., Todo, A., Ogawa, M., Gee, T., Fried, J. (1971). Consideration of the Cell Cycle in Chemotherapy of Acute Leukemia. In: Ultmann, J.E., Griem, M.L., Kirsten, W.H., Wissler, R.W. (eds) Current Concepts in the Management of Lymphoma and Leukemia. Recent Results in Cancer Research, vol 36. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46259-7_13

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  • DOI: https://doi.org/10.1007/978-3-642-46259-7_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46261-0

  • Online ISBN: 978-3-642-46259-7

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