Advertisement

Erzeugung von Krankheiten der Zähne

  • H.-D. Cremer
  • W. Büttner
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 16 / 8)

Zusammenfassung

Krankheiten und Anomalien der Zähne wie Störungen in der Bildung der Zahnhartgewebe durch Hyper-, Hypo- und Avitaminosen, Änderungen der Struktur und Morphologie der Zähne durch Mineralmangel oder Störungen des Mineralhaushaltes und insbesondere die Zahncaries lassen sich bei vielen der gebräuchlichen Laboratoriumstiere erzeugen. Die experimentelle Forschung auf dem Gebiet der Zahnerkrankungen ist in den letzten Jahrzehnten wesentlich erweitert worden und hat wertvolle Beiträge zur Ätiologie sowie für Therapie und Prophylaxe erbracht. Von besonderem Interesse ist die Erzeugung der Zahncaries, denn man hofft, durch weitere Fortschritte in der experimentellen Cariesforschung diese in allen zivilisierten Ländern am meisten verbreitete Krankheit einzudämmen und ihr prophylaktisch wirksam begegnen zu können. Im Vergleich zur Caries ist die Häufigkeit anderer Zahnerkrankungen wesentlich geringer, so daß in den folgenden Ausführungen der Caries ein größerer Raum gewidmet wird. In der experimentellen Zahnmedizin ist dabei die Erzeugung rachitischer Zähne oder das Studium des Einflusses verschiedener Faktoren auf die Bildung der Zahnhartgewebe nicht nur an sich theoretisch und praktisch von Interesse, sondern auf Grund der teilweise bewiesenen, zum Teil aber nur angenommenen und noch unbewiesenen Zusammenhänge zur Caries von Bedeutung für die Ursachenforschung dieses Krankheitsbildes. In den folgenden Abschnitten wird die Erzeugung der einzelnen Zahnerkrankungen im Tierexperiment beschrieben. Hierbei erscheint es angezeigt, neben der Methodik auch jeweils auf die Möglichkeiten einzugehen, inwieweit man tierexperimentelle Ergebnisse auf menschliche Verhältnisse übertragen und pathologische Veränderungen auch für den Menschen auswerten kann.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Aebi, H.: Vitamin-D-Stoffwechsel und Karies. In: Zusammenhang zwischen Ernährung und Zahnkaries. Nutr. et Dieta 5, 82 (1964).Google Scholar
  2. Baer, P. N., and J. E. Lieberman; Periodontal disease in six strains of inbred mice. J. dent. Res. 39, 215 (1960).PubMedGoogle Scholar
  3. Baume, L. J., H. Becks, and H. M. Evans: Hormonal control of tooth eruption. J. dent. Res. 33, 80, 91, 104 (1954).Google Scholar
  4. Becks, H., and W. J. Furuta: Effect of magnesium deficient diets on oral and dental tissues. II. Changes in the enamel structure. J. Amer. dent. Ass. 28, 1083 (1941).Google Scholar
  5. Becks, H., and W. J. Furuta: The effect of magnesium deficient diets on oral and dental structures. III. Changes in the dentine and pulp tissue. Amer. J. Orthodont. Oral Surg. 28, 1 (1942).Google Scholar
  6. Bixler, D., and J. C. Mueller: The relation of systemic fluoride and thyroid gland activity to the incidence of dental caries in the rat. J. dent. Res. 36, 304 (1957).PubMedGoogle Scholar
  7. Bodingbauer, J.: Vergleichende Betrachtungen über das Vorkommen der Karies beim Menschen und beim Hunde. Z. Stomat. 44, 333 (1947).Google Scholar
  8. Bodingbauer, J.: Histopathologische und bakteriologische Studien über die Zahnbeinkaries des Hundes. Vet. Bull. 20, 760 (1950).Google Scholar
  9. Boyle, P. E., O. A. Bessey, and P. R. Howe: Rate of dentin formation in incisor teeth of guinea pigs on normal and on ascorbic acid-deficient diets. Arch. Path. 30, 90 (1940).Google Scholar
  10. Boyle, P. E., S. B. Wolbach, and O. A. Bessey: Histopathology of teeth of guinea pigs in acute and chronic vitamin C deficiency. J. dent. Res. 15, 331 (1936).Google Scholar
  11. Büttner, W., H. D. Cremer AND M. Herrmann: Ernährungsfaktoren bei Zahn-und Knochenbildung. V. Kariesdiagnostik an Zahnschliffen bei der Ratte. Dtsch. zahnärztl. Z. 11, 984 (1956).Google Scholar
  12. Büttner, W., Apparat zur Herstellung unentkalkter Serienschnitte menschlicher Zähne Dtsch. zahnärztl. Z. 11, 1068 (1956).Google Scholar
  13. Büttner, W., Effects of some trace elements on fluoride retention and dental caries. Arch. oral Biol. 6, 40 (1961).Google Scholar
  14. Büttner, W., Vitamin C, B-Vitamine sowie einige weitere Nahrungsfaktoren und Karies. In: Zusammenhang zwischen Ernährung und Zahnkaries. Nutr. et Dieta 5, 100 (1964).Google Scholar
  15. Cheyne, V. D.: A description of the salivary glands of the rat and a procedure for their extirpation. J. dent. Res. 18, 457 (1939a).Google Scholar
  16. Cheyne, V. D.: Effects of salivary gland extirpation upon experimental dental caries in the rat. Proc. Soc. exp. Biol. (N. Y.) 18, 587 (1939b).Google Scholar
  17. Constant, M. A., P. H. Phillips, and C. A. Elvehjem: Dental caries in the cotton rat. 13. The effect of whole grain and processed cereals on dental caries production. J. Nutr. 46, 271 (1952).PubMedGoogle Scholar
  18. Cottier, H.: Strahlenbedingte Lebensverkürzung. Berlin-Göttingen-Heidelberg: Springer-Verlag 1961.Google Scholar
  19. Crampton, E. W.: The growth of the odontoblasts of the incisor teeth as a criterion of the vitamin C intake of the guinea pig. J. Nutr. 33, 491 (1947).PubMedGoogle Scholar
  20. Cremer, H. D.: Caries bei Mensch und Versuchstier, ein Vergleich. Odont. Revy 8, 71 (1957).Google Scholar
  21. Cremer, H. D.: Experimentelle Untersuchungen zur Vitamin-D-Prophylaxe der Karies. In: Vitamin D und Kariesprophylaxe. Bern: Verlag Hans Huber 1958.Google Scholar
  22. Cremer, H. D., and W. Btttner: Karieshemmende Wirkung von Phosphaten. Ernährungs-Umschau 9, 68 (1962).Google Scholar
  23. Cremer, H. D., and H. J. Kinkel: Zeitlicher Verlauf und Erfassung der Karies in einer tierexperimentellen Studie. Arch. oral Biol. 3, 110 (1961).PubMedGoogle Scholar
  24. Dalderup, L. M., and B. C. P. Jansen: Evaluation of dental caries in the rat in non-decalcified sections of the molars. Int. Z. Vitaminforsch. 26, 235 (1955).Google Scholar
  25. English, J. H., C. A. Schlack, and F. Ellinger: Oral manifestations of ionizing radiation. II. Effect of 200 kV X-ray on rat incisor teeth when administered locally to the head in the 1500 R dose range. J. dent. Res. 33, 377 (1954).PubMedGoogle Scholar
  26. Fitzgerald, R. J., and P. H. Keyes: Demonstration of the etiologic role of streptococci in experimental caries in the hamster. J. Amer. dent. Ass. 61, 9 (1960).PubMedGoogle Scholar
  27. Francis, M. D., and A. H. Meckel; The in vitro formation and quantitative evaluation of carious lesions. Arch. oral Biol. 8, 1 (1963).PubMedGoogle Scholar
  28. Gaunt, W. E., and J. T. Irving: The influence of dietary calcium and phosphorus upon tooth formation. J. Physiol. (Lond.) 99, 18 (1940).Google Scholar
  29. Gebauer, H., and C. H. Plathner: Caries am Versuchstier und Ernährung. Dtsch. zahnärztl. Z. 14, 1693 (1959).Google Scholar
  30. Gedicke, K.: Rachitis und Zahnkaries; über die Möglichkeiten der Zahnkaries-Prophylaxe mit Vitamin D-Präparaten im Hinblick auf ihren sozialhygienischen Nutzen. Off. Gesundh.-Dienst 20, 419 (1958).Google Scholar
  31. Gilda, J. E., and P. H. Keyes: Increased dental caries activity in the Syrian hamster following desalivation. Proc. Soc. exp. Biol. (N. Y.) 66, 28 (1947).Google Scholar
  32. Gixx, J. T., and J. F. Volker; Effect of cadmium and fluorine on rat dentition. Proc. Soc. exp. Biol. (N. Y.) 57, 189 (1944).Google Scholar
  33. Gold, H. S., and P. H. Keyes: Periodontal lesions in the Syrian hamster. Oral Surg. 8, 1060 (1955).PubMedGoogle Scholar
  34. Goldman, H. M.: Experimental hyperthyroidism in guinea pigs. Amer. J. Orthodont. Oral Surg. 29, 665 (1943).Google Scholar
  35. Gortrer JR., R. A., and R. K. Kenigsberg: Factors concerned with the different erosive effects of grapefruit and grapefruit juice on rats’ molar teeth. J. Nutr. 46, 133 (1952).Google Scholar
  36. GortrerJR., R. A., J. S. R.starski, J. G. Bieri, and C. M. Mccay: Factors influencing the destructive effects of acidic beverages on the teeth of white rats and hamsters. Arch. Biochem. 8, 405 (1945).Google Scholar
  37. Gustafson, G., E. Stelling, and E. Brunius: Experimental dental caries in the golden hamster with special reference to examination and recording technique. Odont. T. 60, 101 (1952).Google Scholar
  38. Gustafsson, B. E.: Germ-free rearing of rats. Acta path. microbiol. stand., Suppl. LXXIII (1948).Google Scholar
  39. Hadjimarkos, D. M., and C. W. Bonhorst: The trace element selenium and its influence on dental caries susceptibility. J. Pediat. 52, 274 (1958).PubMedGoogle Scholar
  40. Hadjimarkos, D. M., C. A. Storvick, and L. F. Remmert: Selenium and dental caries. J. Pediat. 40, 451 (1952).PubMedGoogle Scholar
  41. Haldi, J., W. Wynn, K. D. Bentley, and M. L. Law: Dental caries in the albino rat in relation to the chemical composition of the teeth and of the diet. IV. Variations in the Ca/P ratio of the diet induced by changing the calcium content. J. Nutr. 67, 645 (1959).PubMedGoogle Scholar
  42. Hansen, L. S., and J. A. English: Histologic changes in the incisor teeth of rats serially sacrificed after receiving 1500 R of 200 kV X-ray irradiation. J. dent. Res. 36, 417 (1957).PubMedGoogle Scholar
  43. Herrmann, M., and F. Rozeik; Einfluß der Rachitis auf die Entstehung der Karies und Parodontitis marginalis chronica progressiva. Dtsch. zahnärztl. Z. 14, 639 (1959).Google Scholar
  44. Heuser, H.: Die Struktur des menschlichen Zahnschmelzes im oberflächenhistologischen Bild (Replica-Technik). Arch. oral Biol. 4, 50 (1961).PubMedGoogle Scholar
  45. Hoppert, C. A., P. A. Webber, and T. L. Canniff: The production of dental caries in rats fed an adequate diet. J. dent. Res. 12, 161 (1932).Google Scholar
  46. Howe, P. R.: Studies on dental disorders following experimental feeding with monkeys. J. Amer. dent. Ass. 11, 1149 (1924a).Google Scholar
  47. Howe, P. R.: Some experimental effects of deficient diets on monkeys. J. Amer. dent. Ass. 11, 1161 (1924b).Google Scholar
  48. Howe, P. R., L. G. Wesson, P. E. Boyle, and S. B. Wolbach: Low calcium rickets in the guinea pig. Proc. Soc. exp. Biol. (N. Y.) 45, 298 (1940).Google Scholar
  49. Hunt, H. R., C. A. Hoppert, and S. Rosen: Genetic factors in experimental rat caries. In: Advances in experimental caries research. Amer. Assoc. for the Advancement of Science, Washington, D.C., S. 66–81 (1955).Google Scholar
  50. Irving, J. T.: Influence of diets low in magnesium on histologic appearance of incisor teeth of rat. J. Physiol. (Lond.) 99, 8 (1940).Google Scholar
  51. Jenkins, G. N.: The physiology of the mouth. Oxford: Blackwell Scientific Publications 1960Google Scholar
  52. Johansen, E., and P. H. Keyes: Production and evaluation of experimental animal caries.Google Scholar
  53. Jenkins, G. N.: A review. In: Advances in experimental caries research. American Association for the Advancement of Science, Washington, D.C., S. 1–46, 1955.Google Scholar
  54. Kalter, H.: The teratogenic effects of hypervitaminosis A upon the face and mouth of inbred mice. In: The metabolism of oral tissues. Ann. N. Y. Acad. Sci. 85, Art. 1, pp. 42–55 (1960).Google Scholar
  55. Keyes, P. H.: Dental caries in the Syrian hamster. I. The character and distribution of lesions. J. dent. Res. 25, 341 (1946).PubMedGoogle Scholar
  56. Keyes, P. H.: Dental caries in the Syrian hamster VIII. The induction of rampant caries activity in albino and golden animals. J. dent. Res. 38, 525 (1959).PubMedGoogle Scholar
  57. Keyes, P. H.: The infectious and transmissible nature of experimental dental caries. Findings and implications. Arch. oral Biol. 1, 304 (1960).PubMedGoogle Scholar
  58. Keyes, P. H., and R. J. Fitzgerald; Dental caries in the Syrian hamster — IX. Arch. oral Biol. 7, 267 (1962).PubMedGoogle Scholar
  59. Kinkel, H. J., F. Kleiner, M. Melzer, and T. M. Marthaler: Evaluation of experimental rat caries. Symmetry of caries frequency in lower jaws of Wistar rats. Hely. odont. Acta 4, 62 (1960).Google Scholar
  60. Kite, O. W., J. H. Shaw, and R. F. Sognnaes: The prevention of experimental tooth decay by tube feeding. J. Nutr. 42, 89 (1950).PubMedGoogle Scholar
  61. König, K. G.: Effects of particle size of corn and sugar diets and of mastication on caries incidence in Osborne-Mendel rats. J. dent. Res. 41, 966 (1962).PubMedGoogle Scholar
  62. König, K. G.: Phosphate und Karies. In: Zusammenhang zwischen Ernährung und Zahnkaries. Nutr. et Dieta 5, 33 (1964).Google Scholar
  63. König, K. G.: Möglichkeiten der Kariesprophylaxe beim Menschen und ihre Untersuchung im kurzfristigen Rattenexperiment. Hans Huber: Bern/Stuttgart 1966.Google Scholar
  64. König, K. G., T. M. Marthaler and H. R. Mühlemann; Methodik der kurzfristig erzeugten Rattenkaries. Dtsch. Zahn-, Mund-and Kieferheilk. 29, 99 (1958).Google Scholar
  65. Korkhaus, G., and T. Jung: Bestrahlungsfolgen am Gesichtsschädel, insbesondere am Gebiß. Strahlenforschung und Strahlenbehandlung, Bd. IV, S. 235–251. Hrsg.: H. MEYER and J. BECKER. München: Verlag Urban & Schwarzenberg 1963.Google Scholar
  66. Krasse, B.: Oral aggregations of microbes. J. dent. Res. 42, 521 (1963).Google Scholar
  67. Larson, R. H.: The effect of EDTA on the pattern of caries development and its association with biologic changes in the rat. J. dent. Res. 38, 1207 (1959).PubMedGoogle Scholar
  68. Losee, F. L., L G Gerende, and J. L. Nemes; A thirty-day cariogenic diet for Osborne-Mendel rats. Md. Res. Proj. NM 008012.01. 14. Naval Med. Res. Inst., Bethesda (1955).Google Scholar
  69. Mannerberg, F.: Changes in the enamel in cases of erosion. Arch. oral Biol. 4, 59 (1961).PubMedGoogle Scholar
  70. Mcclure, F. J.: The cariostatic effect in white rats of phosphorus and calcium supplements added to the flour of bread formulas and to bread diets. J. Nutr. 72, 131 (1960).PubMedGoogle Scholar
  71. Mcclure, F. J.: Effect of diet on alveolar bone resorption. J. dent. Res. 40, 380 (1961).Google Scholar
  72. Mellanby, M.: Diet and the teeth. Part I. Dental structure in dogs. Spec. Rep. Ser. Med. Res. Coun. London No. 140 (1929).Google Scholar
  73. Mellanby, M.: Diet and the teeth: an experimental study. Part III. The effect of diet on dental structure and disease in man. Med. Res. Coun., Brit. Spec. Rep. Ser. No. 191, London (1934).Google Scholar
  74. Miller, W. D.: Die Mikroorganismen der Mundhöhle. Leipzig 1889.Google Scholar
  75. Mitchell, D. F., and W. G. Shafer: The effects of caries-producing diets initiated at various stages of pre-und postnatal development of the hamster J dent. Res. 28, 424 (1949).PubMedGoogle Scholar
  76. Muhler, J. C., W. H. Nebergall, and H. G. Day: Studies on stannous fluoride and other fluorides in relation to the solubility of enamel in acid and the prevention of experimental caries in rats. J. dent. Res. 33, 33 (1954).PubMedGoogle Scholar
  77. Orland, F. J.: Germfree animals in the specific etiology of dental caries. Symposium on recent advances in germfree animal experimentation, Univ. of Massachusetts, Amherst (1963).Google Scholar
  78. Orland, F. J., J. R. Blayney, R. W. Harrison, J. A. Reyniers, P. C. Trexler, H. Gordon, M. Wagner, and T. D. Luckey: Use of the germfree animal technique in the study of experimental dental caries. I. Basic dental study of rats reared free of all microorganisms. J. dent. Res. 33, 147 (1954).Google Scholar
  79. Pigman, W., H. C. Elliott, and R. O. Laffre: An artificial mouth for caries research. J. dent. Res. 31, 627 (1952).PubMedGoogle Scholar
  80. Pigman, W., E. Gilman, R. Powell, and L. Muntz: The action of individual bacterial strains on human teeth under in vitro conditions. J. dent. Res. 36, 314 (1957).PubMedGoogle Scholar
  81. Pindborg, J. J.: The pigmentation of the rat incisor as an index of metabolic disturbances. Oral Surg. 6, 780 (1953).PubMedGoogle Scholar
  82. Rauen, H. M.: Biochemisches Taschenbuch, 1. Aufl., Berlin-Göttingen-Heidelberg: Springer-Verlag 1956.Google Scholar
  83. Restarski, J. S., R. A. Gortner JR., and C. M. Mccay: A method for measuring the effects of acid beverages on the teeth of small laboratory animals. Science 102, 404 (1945).PubMedGoogle Scholar
  84. Reyniers, J A, P. C. Trexler, and R. F. Ervin: Rearing germ-free albino rats. LobundGoogle Scholar
  85. Repts. No 1. Notre Dame, Indiana, USA: Univ. Press 1946.Google Scholar
  86. Rizzo, A. A.: A new mouth prop for oral examinations and operative procedures in rodents. J. dent. Res. 38, 830 (1959).PubMedGoogle Scholar
  87. Rowles, S. L., D. A. S.daway, A. B. Macgregor, and E. A. Marsland: An apparatus for the production of dental caries in vitro. Arch. oral Biol. 8, 311 (1963).Google Scholar
  88. Rushton, M. A., M. Owen, W. Holgate, and J. Vaughan: The relation of radiation dose to radiation damage in the mandible of weanling rabbits. Arch. oral Biol. 3, 235 (1961).PubMedGoogle Scholar
  89. Schmidt, W. J., and A. Keil: Die gesunden und die erkrankten Zahngewebe des Menschen und der Wirbeltiere im Polarisationsmikroskop. München: Carl Hanser-Verlag 1958.Google Scholar
  90. Schour, I., and H. B. VAN Dyke: Changes in the teeth following hypophysectomy. J. dent. Res. 14, 69 (1932).Google Scholar
  91. Schour, I., and M. C. Smith: The histologic changes in the enamel and dentin of the rat incisor in acute and chronic experimental fluorosis. Univ. of Arizona, College of Agriculture, Techn. Bull. No. 52 (1934).Google Scholar
  92. Schwartz, A., and D. Weisberger: Salivary factors in experimental animal caries. in: Advances in experimental caries research. Amer. Assoc. for the Advancement of Science, Washington, D.C., S. 125–136 (1955).Google Scholar
  93. Shafer, W. G., P. G. Clark, D. Bixler, and J. C. Muhler: Salivary gland function in rats. II. Effect of thyroid function on salivary flow and viscosity. Proc. Soc. exp. Biol. (N. Y.) 98, 245 (1958).Google Scholar
  94. Shafer, W. G., and J. C. Muhler; Endocrine factors in experimental animal caries. In: Advances in experimental caries research. Amer. Assoc. for the Advancement of Science, Washington, D.C., S. 137–151 (1955).Google Scholar
  95. Shafer, W. G., and J. C. Muhler, Endocrine influences upon the salivary glands. In: The metabolism of oral tissues. Ann. N. Y. Acad. Sci. 85, Art. 1, pp. 215–227 (1960).Google Scholar
  96. Shaw, J. H.: Effect of nutritional factors on bones and teeth. In: Recent advances in the study of the structure, composition, and growth of mineralized tissues. Ann N Y Acad. Sci. 60, Art. 5, pp. 733–762 (1955).Google Scholar
  97. Shaw, J. H.: A survey of the incidence of dental caries in the rhesus monkey. J. dent. Res. 24, 129 (1945).Google Scholar
  98. C. A. Elvehjem, and P. H. Phillips; The effect of carbohydrate-free and carbohydrate-low diets on the incidence of dental caries in white rats. J. Nutr. 53, 151 (1954).Google Scholar
  99. C. A. Elvehjem, and R. F. Sognnaes: Experimental rat caries. J. Nutr. 53, 207 (1954).Google Scholar
  100. C. A. Elvehjem, and R. F. Sognnaes: Developmental factors in experimental animal caries. In: Advances in experimental caries research. Amer. Assoc. for the Advancement of Science, Washington, D.C., S. 82–106 (1955).Google Scholar
  101. Sobel, A. E., and A. Hanok: Calcification of teeth. I. Composition in relation to blood and lymph. J. biol. Chem. 176, 1103 (1948).Google Scholar
  102. Sobel, A. E., J. H. Shaw, A. Hanok, and S. Nobel: Calcification. XXVI. Caries susceptibility in relation to composition of teeth and diet. J. dent. Res. 39, 462 (1960).PubMedGoogle Scholar
  103. Sognnaes, R. F.: Caries-conducive effect of a purified diet when fed to rodents during tooth development. J. Amer. dent. Ass. 37, 676 (1948).PubMedGoogle Scholar
  104. Sognnaes, R. F.: Experimental rat caries. II. Location, sequence and extent of carious lesions produced in the Norway rat when raised on a generally adequate, finely powdered, purified ration. J. Nutr. 39, 139 (1949).PubMedGoogle Scholar
  105. Stephan, R. M.: The development of caries on the buccal and lingual tooth surfaces of rats as well as proximal and fissure caries. J. dent. Res. 30, 484 (1951).Google Scholar
  106. Stephan, R. M., and M. R. Harris: Location of experimental caries on different tooth surfaces in the Norway rat. In: Advances in experimental caries research. Amer. Assoc. for the Advancement of Science, Washington, D.C., S. 47–65 (1955).Google Scholar
  107. Stöckli, P; Einfluß einiger Phosphate auf die Morphologie der Schmelzoberfläche. Med. Diss., Zürich 1963.Google Scholar
  108. Tank, G., and C. A. Storvick: Effect of naturally occurring selenium and vanadium on dental caries. J. dent. Res. 39, 473 (1960).PubMedGoogle Scholar
  109. Wagner, M.: The possible influence of antibody on experimental dental caries in the gnotobiotic rat. Symposium on recent advances in germfree animal experimentation. Univ. of Massachusetts, Amherst (1963).Google Scholar
  110. Weinmann, J. P., and I. Schour: Experimental studies in calcification. I. The effect of a rachitogenic diet on the dental tissues of the white rat. Amer. J. Path. 21, 821 (1945).Google Scholar
  111. Westin, G.: Scorbutic changes in the teeth and jaws in man. Dent. Cosmos 67, 868 (1925).Google Scholar
  112. Wolbach, S. B., and P. R. Howe: The effect of the scorbutic state upon the production and maintenance of intercellular substances. Proc. Soc. exp. Biol. (N. Y.) 22, 400 (1925).Google Scholar
  113. Wolbach, S. B., and P. R. Howe, The incisor teeth of albino rats and guinea pigs in vitamin A deficiency and repair. Amer. J. Path. 9, 275 (1933).PubMedGoogle Scholar
  114. Wolf, J.: Plastische Histologie der Zahngewebe. Dtsch. Zahn-, Mund-and Kieferheilk. 7, 265, 507, 678 (1940).Google Scholar
  115. Wynn, W., and J. Halni, The erosive action of various fruit juices on the lower molar teeth of the albino rat. J. Nutr. 35, 489 (1948).PubMedGoogle Scholar
  116. Wynn, W., and J. Halni, K. D. Bentley, and M. L. Law: Dental caries in the Albino rat in relation to the chemical composition of the teeth and of the diet. II. Variations in the Ca/P ratio of the diet induced by changing the phosphorus content. J. Nutr. 58, 325 (1956).PubMedGoogle Scholar
  117. Zilva, S. S., and F. M. Wells; Changes in the teeth of the guinea pig, produced by a scorbutic diet. Proc. roy. Soc. B, London 90, 505 (1919).Google Scholar
  118. Zipkin, I., and F. J. Mcclure: Potentiation of smooth surface caries by sodium dehydroacetate variously administered to white rats. Proc. Soc. exp. Biol. (N. Y.) 97, 318 (1958).Google Scholar

Copyright information

© Springer-Verlag, Berlin · Heidelberg 1969

Authors and Affiliations

  • H.-D. Cremer
  • W. Büttner

There are no affiliations available

Personalised recommendations