Abstract
Drug metabolism refers to any chemical change which a drug undergoes during its sojourn in the body. These chemical changes can involve oxidation, reduction, cleavage (most often hydrolysis) and conjugation (with glucuronic acid, etc.). These chemical changes can have quite different effects on the action of any given drug, and the point I wish to emphasize is that drug metabolism and detoxication are not synonymous. Drug metabolism can cause little or no change in drug action, increase in drug action, or decrease in drug action. Besides these quantitative considerations, metabolism can affect drug action qualitatively—making a stimulant of the central nervous system from an inactive parent molecule or a molecule having a CNS depressant action.
This research was supported by grants from the National Institute of General Medical Sciences, National Institutes of Health, Bethesda, Maryland (Grants GM-06034 and GM-12675).
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Fouts, J.R. (1968). Hepatic Microsomal Drug Metabolism in the Perinatal Period. In: Adamsons, K. (eds) Diagnosis and Treatment of Fetal Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46172-9_22
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DOI: https://doi.org/10.1007/978-3-642-46172-9_22
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