Abstract
Although it is known that red blood cells can be transferred intact from the peritoneal cavity to circulating blood by lymphatic channels (Florey and Witts, 1928; Courtice et al., 1953), the rate and efficiency of absorption from this site during intrauterine life has received little attention. However in recent years, the administration of blood to the human fetus by the intraperitoneal route in severe erythroblastosis fetalis has aroused further interest in this subject. In 1922, Cunningham carried out experiments on fetal kittens; after exposing the fetus to the presence of India ink in the peritoneal cavity for one hour, he found that the entry of material into mediastinal lymph nodes only occurred in association with the respiratory activity which he observed in older fetuses. Since then, the role of diaphragmatic movement in accelerating the rate of absorption of particulate matter and red cells from the peritoneal cavity has been established (Morris, 1953; Yoffey and Courtice, 1956). Thus it was postulated that uptake of blood might be slow and less efficient in the fetus owing to the absence of respiratory activity under normal intrauterine conditions.
Supported by Medical Research Council Grant MA 2500.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bowman, J. M. In Intrauterine Transfusion and Erythroblastosis Fetalis, Report of the Fifty-third Ross Conference on Pediatric Research. J. F. Lucey, and L. J. Butterfield, eds. Columbus, Ross Laboratories, 1966, p. 99.
Courtice, F. C, J. Harding, and A. W. Steinbeck. The removal of free red blood cells from the peritoneal cavity of animals. Austral. J. Exp. Biol. 31: 215, 1953.
Cunningham, R. S. Studies in absorption from serous cavities. V. The absorption of particulate matter from the peritoneal cavity of the fetus. Amer. J. Physiol. 62:253, 1922.
Drury, A. N., and E. M. Tucker. The relationship between natural and immune haemolysins and incompatibility of 51Cr labelled red cells in the sheep. Immunology 1:204, 1958.
Florey, H., and L. J. Witts. Absorption of blood from the peritoneal cavity. Lancet 1:1323, 1928.
Hahn, P. F., L. L. Miller, F. S. Robscheit-Robbins, W. F. Bale, and G. H. Whipple. Peritoneal absorption. Red cells labelled by radio-iron hemoglobin move promptly from peritoneal cavity into the circulation. J. Exper. Med. 80:77, 1944.
Hollingsworth, J. W. Disappearance of radioactive chromium tagged erythrocytes from tissues and body cavities of rabbits. Proc. Soc. Exp. Biol. & Med. 87:493, 1954.
Morris, B. The effect of diaphragmatic movement on the absorption of protein and of red cells from the peritoneal cavity. Austral. J. Exp. Biol. & Med. 31: 239, 1953.
Phibbs, R. H., P. Johnson, and W. H. Tooley. Circulatory changes in newborns with erythroblastosis fetalis with and without hydrops. Pediat. Res. 1:321, 1967.
Pritchard, J. A., and R. Weisman. The absorption of labelled erythrocytes from the peritoneal cavity of humans. J. Lab. & Clin. Med. 49:756, 1957.
Ullrey, D. E., E. R. Miller, C. H. Long, and B. H. Vincent. Sheep haematology from birth to maturity. I. Erythrocyte population, size and hemoglobin concentration. J. Animal Sci. 24:135, 1965.
Taylor, W. W., D. E. Scott, and J. A. Pritchard. Fate of compatible adult erythrocytes in the fetal peritoneal cavity. Obstet. & Gynec. 28:175, 1966.
Yoffey, J. M., and F. C. Courtice. Lymphatics, Lymph and Lymphoid Tissue. Cambridge, Mass.: Harvard University Press, 1956.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1968 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Towell, M.E., Gregg, J.R., Salvador, H.S., Solvonuk, P.F. (1968). Intraperitoneal Blood Transfusion in the Fetal Lamb. In: Adamsons, K. (eds) Diagnosis and Treatment of Fetal Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46172-9_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-46172-9_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-46174-3
Online ISBN: 978-3-642-46172-9
eBook Packages: Springer Book Archive