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Current Topics in Microbiology and Immunology pp 37–77Cite as

Significance of Complement to the Mechanism of Action of Endotoxin

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 50))

Abstract

Bacterial endotoxins are derived from the outer membrane of the complex cell wall of gram negative bacteria (Mergenhagen et al., 1966; Bladen et al., 1967) and are macromolecular structures containing polysaccharide, phospholipid, and small quantities of protein. Over the years much of the interest in bacterial endotoxins (lipopolysaccharides) has arisen because of the diversity of physiopathological and immunological effects these products have on the host. The biochemist has largely been concerned with the chemical and molecular basis for endotoxin action while the immunobiologist has tried to relate biological activity to the well-established fact that endotoxins are potent antigens and may give rise to some as yet ill-defined forms of hypersensitivity phenomena. Several recent symposia and reviews pertaining to the historical, immunobiological, and chemical interests of bacterial endotoxins have been compiled (Landy and Braun, 1964; Zweifach and Janoff, 1965; Nowotny, 1966; Lüderitz et al., 1968; Neter, 1969) and it is out of the scope of this discussion to reiterate what has already been well documented in the literature except where certain of these references have a direct bearing on the subject at hand.

Supported in part by National Science Foundation Grant GB-2597, USPHS Grant AI-02566-09, Contract ONR 248(60) with the Office of Naval Research and USPHS Training Grant No. 5 TI-AI 282-03.

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Author information

Author notes

  1. Henry Gewurz (Established Investigator)

    Present address: Departments of Pediatrics and Surgery, University of Minnesota, USA

Authors and Affiliations

  1. Immunology Section, Laboratory of Microbiology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, 20014, USA

    Stephan E. Mergenhagen & Ralph Snyderman

  2. American Heart Association, USA

    Henry Gewurz (Established Investigator)

  3. Department of Microbiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Hyun S. Shin

Authors
  1. Stephan E. Mergenhagen
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  2. Ralph Snyderman
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  3. Henry Gewurz
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  4. Hyun S. Shin
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Editor information

Editors and Affiliations

  1. Genève, Switzerland

    W. Arber

  2. New Brunswick, USA

    W. Braun

  3. Göttingen, Germany

    F. Cramer

  4. Freiburg, Germany

    R. Haas

  5. Philadelphia, USA

    W. Henle  & H. Koprowski  & 

  6. München, Germany

    P. H. Hofschneider

  7. Basel, Germany

    N. K. Jerne

  8. Prague, Czech Republic

    P. Koldovský  & L. Syruček  & 

  9. Copenhagen, Denmark

    O. Maaløe

  10. Gießen, Germany

    R. Rott

  11. Wilhelmshaven, Germany

    H. G. Schweiger

  12. Rehovoth, Israel

    M. Sela

  13. Seattle, USA

    P. K. Vogt

  14. Würzburg, Germany

    E. Wecker

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© 1969 Springer-Verlag Berlin · Heidelberg

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Mergenhagen, S.E., Snyderman, R., Gewurz, H., Shin, H.S. (1969). Significance of Complement to the Mechanism of Action of Endotoxin. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 50. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46169-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-46169-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

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