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Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung pp 1–79Cite as

The Herpesviruses — A Biochemical Definition of the Group

  • Conference paper

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 49))

Abstract

The first version of this paper was written to introduce new students and fellows of my laboratory to the mysteries of herpesviruses. Consonant with this design sections dealing with well documented data were trimmed to the bone whereas many obscure phenomena, controversial data and seemingly trivial observations were discussed generously and at length. There is some doubt as to whether it was meant to be published, but it was not a review. The objective of reviews is frequently to bring order. But alas, even the most fluent summation of credible data frequently makes dull reading and too much plausible order, like very little entropy in chemical reactions, is not the most suitable environment on which to nurture the urge to discover. This version is more charitable but not less inbalanced. The bibliography reflects the intent of the paper and was updated last in December of 1968. It should be obvious without saying that no single account such as this can do justice or injustice, as the case may be, to the several hundred papers published on herpesviruses each year or to the many thousand papers published on herpesviruses since the first of the members of the family was experimentally transmitted to a heterologous host more than half a century ago (Gruter, 1924).

“When we give a definition it is for the purpose of using it”.

Henri Poincare in Science and Method

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References

  • Albrecht, P., J. Blaskovic, J. Jakubik, and J. Lesso: Demonstration of pseudo-rabies virus in chick embryo cell cultures and infected animals by the fluorescent antibody technique. Acta virol. 7, 289–296 (1963).

    Google Scholar 

  • Almeida, J. D., A. P. Waterson, and W. Plowright: The morphological characteristics of African Swine fever virus and its resemblence to tipula irridescent virus. Arch. ges. Virusforsch. 20, 392–396 (1967).

    PubMed  CAS  Google Scholar 

  • Amos, H.: The inactivation of herpes simplex virus by phosphatase enzymes. J. exp. Med. 98, 365–372 (1953).

    PubMed  CAS  Google Scholar 

  • Andrews, C. H.: Classification of viruses of vertebrates. Advanc. Virus Res. 9, 271–296 (1962).

    Google Scholar 

  • Ashe, W. K., and H. W. Scherp: Antigenic variations in herpes simplex virus isolates from successive recurrences of herpes labialis. J. Immunol. 94, 385–394 (1965).

    PubMed  CAS  Google Scholar 

  • Aurelian, L., and B. Roizman: Abortive infection of canine cells by herpes simplex virus. II. The alternative suppression of synthesis of interferon and viral constituents. J. molec. Biol. 11, 539–548 (1965).

    PubMed  CAS  Google Scholar 

  • Becker, P., J. L. Melnick, and H. D. Mayor: A morphologic comparison between the developmental stages of herpes zoster and human cytomegalovirus. Exp. molec. Path. 4, 11–23 (1965).

    Google Scholar 

  • Becker, Y., H. Dym, and I. Sarov: Herpes simplex virus DNA. Virology 36, 184–192 (1968).

    PubMed  CAS  Google Scholar 

  • Becker, Y., U. Olshevsky, and J. Levitt: The role of arginine in the replication of herpes simplex virus. J. gen. Virol. 1, 471–478 (1967).

    PubMed  CAS  Google Scholar 

  • Bedson, S. P., and J. V. T. Gostling: Further observations on the mode of multiplication of herpes virus. Brit. J. exp. Path. 39, 502–509 (1958).

    PubMed  CAS  Google Scholar 

  • Beilby, J. O. W., C. H. Cameron, R. D. Catterall, and D. Davidson: Herpesvirus hominis infection of cervix associated with gonorrhea. Lancet 1968 I, 1065–1066.

    Google Scholar 

  • Benda, R.: Attempt to differentiate B virus from herpes simplex virus by the fluorescent antibody technique. Acta virol. 10, 348–353 (1966a).

    PubMed  CAS  Google Scholar 

  • Benda, R.: Effect of heparin on B virus multiplication in vitro. Acta virol. 10, 376 (1966b).

    PubMed  CAS  Google Scholar 

  • Ben-Porat, T., and A. S. Kaplan: The chemical composition of herpes simplex and Pseudorabies viruses. Virology 16, 261–266 (1962).

    PubMed  CAS  Google Scholar 

  • Ben-Porat, T., and A. S. Kaplan: The synthesis and fate of Pseudorabies virus DNA in infected mammalian cells in the stationary phase of growth. Virology 20, 310–317 (1963).

    PubMed  CAS  Google Scholar 

  • Ben-Porat, T., and A. S. Kaplan: Mechanism of inhibition of cellular DNA synthesis by Pseudorabies virus. Virology 25, 22–29 (1965).

    PubMed  CAS  Google Scholar 

  • Benyesh-Melnick, M., F. Probstmeyer, R. McCombs, J. P. Brunschwig, and V. Vonka: Correlation between infectivity and physical virus particles in human cytomegalovirus. J. Bact. 92, 1555–1561 (1966).

    PubMed  CAS  Google Scholar 

  • Benyesh-Melnick, M., H. F. Stich, F. Rapp, and T. C. Hsu: Viruses and mammalian chromosomes. III. Effect of herpes zoster virus on human embryonal lung cultures. Proc. Soc. exp. Biol. (N.Y.) 117, 546–549 (1964).

    CAS  Google Scholar 

  • Bernhard, W.: Ultrastructural aspects of the normal and pathological nucleolus in mammalian cells. Nat. Cancer Inst. Monogr. 23, 13–38 (1966).

    PubMed  CAS  Google Scholar 

  • Beswick, T. S. L.: The origin and the use of the word herpes. Med. Hist. 6, 214–232 (1962).

    PubMed  CAS  Google Scholar 

  • Black, F. L., and J. L. Melnick: Microepidemiology of poliomyelitis and herpes-B infections; spread of the viruses within tissue cultures. J. Immunol. 74, 236–242 (1955).

    PubMed  CAS  Google Scholar 

  • Blank, H., and M. W. Brody: Recurrent herpes simplex: a psychiatric and laboratory study. Psychosom. Med. 12, 254–260 (1950).

    PubMed  CAS  Google Scholar 

  • Bocciarelli, D.S., Z. Orfei, G. Mondino, and A. Persechino: The core of a bovine herpes virus. Virology 30, 58–61 (1966).

    PubMed  CAS  Google Scholar 

  • Boiron, M., J. Tänzer, M.Thomas, and A. Hampe: Early diffuse chromosome alterations in monkey kidney cells infected in vitro with herpes simplex virus. Nature (Lond.) 209, 737–738 (1966).

    CAS  Google Scholar 

  • Brunell, P. A.: Separation of infectious varicella-zoster virus from human embryonic lung fibroblasts. Virology 31, 732–734 (1967).

    PubMed  CAS  Google Scholar 

  • Burkitt, D.: A sarcoma involving the jaws in African children. Brit. J. Surg. 46, 218–223 (1958).

    PubMed  CAS  Google Scholar 

  • Burkitt, D.: Long term permissions following one and two dose chemotherapy for African lymphoma. Cancer (Philad.) 20, 756–759 (1967).

    CAS  Google Scholar 

  • Carmichael, L. E., J. D. Strandberg, and F.D.Barnes: Identification of a cytopathogenic agent infectious for puppies as a canine herpesvirus. Proc. Soc. exp. Biol. (N.Y.) 120, 644–650 (1965).

    CAS  Google Scholar 

  • Carter, W. A., and H. B. Levy: Ribosomes: effect of interferon on their interaction with rapidly labeled cellular and viral RNAs. Science 155, 1254–1255 (1967).

    PubMed  CAS  Google Scholar 

  • Carter, W. A., and H. B. Levy: The recognition of viral RNA by mammalian ribosomes an effect of interferon. Biochem. biophys. Acta (Amst.) 155, 437–443 (1968).

    CAS  Google Scholar 

  • Caunt, A. E., and D.Taylor-Robinson: Cell-free varicella-zoster virus in tissue culture. J. Hyg. (Camb.) 62, 413–424 (1964).

    CAS  Google Scholar 

  • Clifford, P., S. Singh, J. Stjernsward, and G. Klein: Long-term survival of patients with Burkitt’s lymphoma: an assessment of treatment and other factors which may relate to survival. Cancer Res. 27, 2578–2617 (1967).

    PubMed  CAS  Google Scholar 

  • Cook, M. L., and J. G. Stevens: Labile coat: Reason for non infectious cell-free Varicella-Zoster virus in culture. J. Virol. 2, 1458–1464 (1968).

    PubMed  CAS  Google Scholar 

  • CoRiell, L. L.: Discussion to paper by B. Roizman. In: Viruses, nucleic, acids and cancer, p. 241. Baltimore, Maryland: William Wilkins Co. 1963.

    Google Scholar 

  • Crawford, L. V., and A. J. Lee: The nucleic acid of human cytomegalovirus. Virology 23, 105–107 (1964).

    PubMed  CAS  Google Scholar 

  • Dales, S.: An electron microscopic study of the early association between two mammalian viruses and their hosts. J. Cell Biol. 13, 303–322 (1962).

    PubMed  CAS  Google Scholar 

  • Dales, S., P. J. Gomatos, and K. C. Hsu: The uptake and development of reovirus in strain L cells followed with labeled viral ribonucleuc acid and ferritin antibody conjugates. Virology 25, 193–211 (1965).

    PubMed  CAS  Google Scholar 

  • Darlington, R. W., A. Granoff, and D. C. Breeze: Viruses and renal carcinoma of Rana pipiens. IL Ultrastructural studies and sequestial development of virus isolated from normal and tumor tissue. Virology 29, 149–156 (1966).

    PubMed  CAS  Google Scholar 

  • Darlington, R. W., and L. H. Moss III.: Herpes virus envelopment. J. Virol. 2, 48–55 (1968).

    PubMed  CAS  Google Scholar 

  • Darlington, R. W., and C. C. Randall: The nucleic acid content of equine abortion virus. Virology 19, 322–327 (1963).

    PubMed  CAS  Google Scholar 

  • Dowdle, W. R., A. J. Nahmias, R. W. Harwell, and F. P. Pauls: Association of antigenic type of herpesvirus hominis with site of viral recovery. J. Immunol. 99, 974–980 (1967).

    PubMed  CAS  Google Scholar 

  • Duxbury, A. E., and J. R. Lawrence: Primary venereal herpes simplex infection in male. Med. J. Aust. 46, 250–252 (1959).

    PubMed  Google Scholar 

  • Eagle, H.: Amino acid metabolism in mammalian cell culture. Science 130, 432–437 (1959).

    PubMed  CAS  Google Scholar 

  • Ejercito, P. M., E. D. Kieff, and B. Roizman: Characterization of herpes simplex virus strains differing in their effect on social behavior of infected cells. J. gen. Virol. 3, 357–364 (1968).

    Google Scholar 

  • Epstein, M. A.: Observations on the fine structure of mature herpes simplex virus and on the composition of its nucleoid. J. exp. Med. 115, 1–11 (1962a).

    PubMed  CAS  Google Scholar 

  • Epstein, M. A.: Observations on the mode of release of herpes virus from infected HeLa cells. J. Cell Biol. 12, 589–597 (1962b).

    PubMed  CAS  Google Scholar 

  • Epstein, M. A., B. G. Achong, and Y. M. Barr: Virus particles in culturedlympho blasts from Burkitt’s lymphoma. Lancet 1964 II, 702–703.

    Google Scholar 

  • Epstein, M. A., B. G. Achong, A. E. Churchill, and P. M. Biggs: Structure and development of the herpes-type virus of Marek’s disease. J. nat. Cancer 41, 805–820 (1968).

    CAS  Google Scholar 

  • Epstein, M. A., and Y. M. Barr: Characteristics and mode of growth of a tissue culture strain (EBI) of human lymphoblasts from Burkitt’s lymphoma. J. nat. Cancer Inst. 34, 231–240 (1965).

    PubMed  CAS  Google Scholar 

  • Epstein, M. A., K. Hummeler, and A. Berkaloft: The entry and distribution of herpes virus and colloidal gold in HeLa cells after contact in suspension. J. exp. Med. 119, 291–302 (1964a).

    PubMed  CAS  Google Scholar 

  • Falke, D.: Isolation of two variants with different cytopathic properties from a strain of herpes B virus. Virology 14, 492–495 (1961).

    PubMed  CAS  Google Scholar 

  • Falke, D.: Lipoid-analysen bei Riesenzellbildung durch herpesvirus hominis. Z. Naturforsch. 22, 1360–1362 (1967).

    CAS  Google Scholar 

  • Falke, D., R. Siegert u. W. Vogell: Elektronenmikroskopische Befunde zur Frage der Doppelmembranbildung des Herpes-simplex-Virus. Arch. ges. Virusforsch. 9, 484–496 (1959).

    PubMed  CAS  Google Scholar 

  • Farnham, A. E., and A. A. Newton: The effect of some environmental factors on herpes virus grown in HeLa cells. Virology 7, 449–461 (1959).

    PubMed  CAS  Google Scholar 

  • Fawcett, O. W.: Electron microscopic observations on intracellular virus like particles associated with the cells of the Lucké renal adenocarcinoma. J. biophys. biochem. Cytol. 2, 725–742 (1956).

    PubMed  CAS  Google Scholar 

  • Felluga, B.: Electron microscopic observations of Pseudorabies virus development in a line of pig kidney cells. Ann. Sclavo 5, 412–424 (1963).

    Google Scholar 

  • Flanagan, J. F.: Hydrolytic enzymes in KB cells infected with poliovirus and herpes simplex virus. J. Bact. 91, 789–797 (1966).

    PubMed  CAS  Google Scholar 

  • Flanagan, J. F.: Virus-specific ribonucleic acid synthesis in KB cells infected with herpes simplex virus. J. Virol. 1, 583–590 (1967).

    PubMed  CAS  Google Scholar 

  • Frearson, P.M., S.Kit, and D. R. Dubbs: Deoxythymidylate synthetase and deoxythymidine kinase activities of virus-infected animal cells. Cancer Res. 25, 737–744 (1965).

    PubMed  CAS  Google Scholar 

  • Fujiwara, S., and A. S. Kaplan: Site of protein synthesis in cells infected with Pseudorabies virus. Virology 32, 60–68 (1967).

    PubMed  CAS  Google Scholar 

  • Geder, L., F. Lehel, E. Jeney, and E. Gonczol: Further studies on localization and immunological properties of antigens induced by herpes simplex virus in HEp-2 cells. Acta microbiol. Acad. Sci. hung. 15, 151 (1968).

    CAS  Google Scholar 

  • Geder, L., and L. Vaczi: Localization of nuclear and cytoplasmic herpes simplex antigens in infected cells by immunofluorescence. Acta virol. 12, 97–105 (1968).

    PubMed  CAS  Google Scholar 

  • Geder, L., L. Vaczi, E. Gonczol, E. Jeney, and F. Lehel: “Early, nonvirion” antigens in herpes simplex virus infected tissue culture cells. I. Detection of “early” antigens with complement fixation test. Acta microbiol. Acad. Sci. hung. 13, 357–364 (1967a).

    CAS  Google Scholar 

  • Geder, L., L. Vaczi, E. Jeney, E. Gonczol, and F. Lehel: “Early, nonvirion” antigens in herpes simplex virus infected tissue culture cells. II. Intracellular localization of “early” antigen with indirect immunofluorescence technique. Acta microbiol. Sci. hung. 13, 365–372 (1967b).

    CAS  Google Scholar 

  • Gold, E., P. Wildy, and D. H. Watson: The development of infectivity, antigens and particles in herpes infected cells. J. Immunol. 91, 666–669 (1963).

    PubMed  CAS  Google Scholar 

  • Gonczol, E., E. Jeney, and L. Vaczi: Replication of herpes simplex virus in arginine-free media. II. DNA synthesis in infected and non-infected human embryonic fibroblast and HeLa tissue culture cells. Acta microbiol. Acad. Sci. hung. 14, 39–43 (1967).

    PubMed  CAS  Google Scholar 

  • Goodheart, C. R., G. Plummer, and J. L. Waner: Density difference of DNA of human herpes simplex viruses types I and II. Virology 35, 473–475 (1968).

    PubMed  CAS  Google Scholar 

  • Granboulan, N., P. Tournier, R. Wicker, and W. Bernhard: An electron microscope study of development of SV-40 virus. J. Cell Biol. 17, 423–441 (1963).

    PubMed  CAS  Google Scholar 

  • Granoff, A., P. E. Came, and K. A. Rafferty: The isolation and properties of viruses from Rana pipiens: their possible relationship to the renal adenocarcinoma of the leopard frog. Ann. N.Y. Acad. Sci. 126, 237–255 (1965).

    PubMed  CAS  Google Scholar 

  • Granoff, A., M. Gravell, and R. W. Darlington: Studies on the viral etiology of the frog renal carcinoma (Lucké tumor). In: Symposium on the Biology of Amphibian Tumors. Berlin-Heidelberg-New York: Springer 1969 (in press).

    Google Scholar 

  • Gravell, M., A. Granoff, and R. W. Darlington: Viruses and renal carcinoma of Rana pipiens. Virology 36, 467–475 (1968).

    PubMed  CAS  Google Scholar 

  • Gray, A., T. Tokumaru, and T. F. Scott: Different cytopathogenic effects observed in HeLa cells infected with herpes simplex virus. Arch. ges. Virusforsch. 8, 60–76 (1958).

    Google Scholar 

  • Gresser, I., and J. F. Enders: The effect of trypsin on representative myxoviruses. Virology 13, 420–426 (1961).

    PubMed  CAS  Google Scholar 

  • Gruter, W.: Das herpesvirus, seine ätiologische und klinische Bedeutung. Münch. med. Wschr. 71, 1058–1060 (1924).

    Google Scholar 

  • Hadhazy, G., F. Lehel, and L. Gergely: Studies on the influence of endogenous regulatory factors on the growth of herpes simplex virus. Acta microbiol. Acad. Sci. hung. 13, 145–150 (1966).

    PubMed  CAS  Google Scholar 

  • Hamada, C., T. Kamiya, and A. S. Kaplan: Serological analysis of some enzymes present in Pseudorabies virus-infected and uninfected cells. Virology 28, 271–281 (1966).

    PubMed  CAS  Google Scholar 

  • Hamada, C., and A. S. Kaplan: Kinetics of synthesis of various types of antigenic proteins in cells infected with Pseudorabies virus. J. Bact. 89, 1328–1334 (1965).

    PubMed  CAS  Google Scholar 

  • Hampar, B., and S.A. Ellison: Chromosomal aberrations induced by an animal virus. Nature (Lond.) 192, 445–147 (1961).

    Google Scholar 

  • Hampar, B., and S.A. Ellison: Cellular alterations in the MCH line of Chinese Hamster cells following infection with herpes simplex virus. Proc. nat. Acad. Sci. (Wash.) 49, 474–480 (1963).

    CAS  Google Scholar 

  • Hampar, B., and M. A. Keehn: Cumulative changes in the antigenic properties of herpes simplex virus from persistently infected cell cultures. J. Immunol. 99, 554–557 (1967).

    PubMed  CAS  Google Scholar 

  • Hay, J., G. J. Koteles, H. M. Keir, and H. Subak-Sharpe: Herpes virus specified ribonucleic acids. Nature (Lond.) 210, 387–390 (1966).

    CAS  Google Scholar 

  • Hay, J., H. Subak-Sharpe, and W. M. Shepherd: New transfer ribonucleic acid in BHK-21/C13 cells infected with herpes virus. Biochem. J. 103, 69 (1967).

    Google Scholar 

  • Henle, G., and W. Henle: Immunofluorescence in cells derived from Burkitt’s lymphoma. J. Bact. 91, 1248–1256 (1966a).

    PubMed  CAS  Google Scholar 

  • Henle, G., and W. Henle: Studies on cell lines derived from Burkitt’s lymphoma. Trans. N.Y. Acad. Sci. 29, 71–79 (1966b).

    PubMed  CAS  Google Scholar 

  • Henle, G., W. Henle, and V. Diehl: Relation of Burkitt’s tumor-associated herpes-type virus to infectious mononucleosis. Proc. nat. Acad. Sci. (Wash.) 59, 94–101 (1968).

    CAS  Google Scholar 

  • Henle, W., and G. Henle: Effect of arginine-deficient media on the herpes-type virus associated with cultured Burkitt tumor cells. J. Virol. 2, 182–191 (1968).

    PubMed  CAS  Google Scholar 

  • Hinuma, Y., M. Konn, J. Yamaguchi, D. J. Wudarski, J. R. Blakeslee Jr., and J. T. Grace: Immunofluorescence and herpes-type virus particles in the P3HR-I Burkitt lymphoma cell line. J. Virol. 1, 1045–1051 (1967).

    PubMed  CAS  Google Scholar 

  • Hinze, H. C., and D. L. Walker: Variation of herpes simplex virus in persistently infected tissue cultures. J. Bact. 82, 498–504 (1961).

    PubMed  CAS  Google Scholar 

  • Hochberg, E., and Y. Becker: Adsorption, penetration and uncoating of herpes simplex virus. J. gen. Virol. 2, 231–241 (1968).

    PubMed  CAS  Google Scholar 

  • Hoggan, M. D., and B. Roizman: The isolation and properties of a variant of herpes simplex producing multinucleated giant cells in monolayer cultures in the presence of antibody. Amer. J. Hyg. 70, 208–219 (1959a).

    PubMed  CAS  Google Scholar 

  • Hoggan, M. D., and B. Roizman: The effect of the temperature of incubation on the formation and release of herpes simplex virus in infected FL cells. Virology 8, 508–524 (1959b).

    PubMed  CAS  Google Scholar 

  • Hoggan, M. D., B. Roizman, and T. B. Turner: The effect of the temperature of incubation on the spread of herpes simplex virus in an immune environment in cell culture. J. Immunol. 84, 152–159 (1960).

    PubMed  CAS  Google Scholar 

  • Holden, M.: Nature and properties of herpes virus. J. infect. Dis. 50, 218–236 (1932).

    CAS  Google Scholar 

  • Holmes, I. H., and D. H. Watson: An electron microscope study of the attachment and penetration of herpes virus in BHK-21 cells. Virology 21, 112–123 (1961).

    Google Scholar 

  • Huang, A. S., and R. R. Wagner: Penetration of herpes simplex virus into human epidermoid cells. Proc. Soc. exp. Biol. (N.Y.) 116, 863–869 (1964).

    CAS  Google Scholar 

  • Huang, C. C.: Induction of a high incidence of damage to x chromosomes of Rattus (mastomys) natalensis by base analogues, viruses and carcinogens. Chromosoma (Berl.) 23, 162–179 (1967).

    CAS  Google Scholar 

  • Hummeler, K., G. Henle, and W. Henle: Fine structure of a virus in cultured lymphoblasts from Burkitt lymphoma. J. Bact. 91, 1366–1368 (1966).

    PubMed  CAS  Google Scholar 

  • Inglis, V. B. M.: Requirement of arginine for replication of herpes virus. J. gen. Virol. 3, 9–18 (1968).

    PubMed  CAS  Google Scholar 

  • Ivanicova, S., R. Skoda, V. Mayer, and F. Sokol: Inactivation of Ausjesky. disease (Pseudorabies) virus by nitrous acid. Acta virol. 7, 7–15 (1963) [Engl.]

    CAS  Google Scholar 

  • Jeney, E., E. Gonczol, and L. Vaczi: Replication of herpes simplex virus in arginine-free media. I. Effect of arginine-deficiency in different tissue culture cells. Acta microbiol. Acad. Sci. hung. 14, 31–37 (1967).

    CAS  Google Scholar 

  • Josey, W. E., A. J. Nahmias, and Z. M. Naib: Genital infection with Type 2 herpesvirus hominis - present knowledge and possible relation to cervical cancer. Amer. J. Obstet. Gynec. 101, 718–729 (1968).

    Google Scholar 

  • Kamiya, T., T. Ben-Porat, and A. S. Kaplan: The role of progeny viral DNA in the regulation of enzyme and DNA synthesis. Biochem. biophys. Res. Commun. 16, 410–415 (1964).

    PubMed  CAS  Google Scholar 

  • Kamiya, T., T. Ben-Porat, and A. S. Kaplan: Control of certain aspects of the infective process by progeny viral DNA. Virology 26, 577–589 (1965).

    PubMed  CAS  Google Scholar 

  • Kaplan, A. S.: A study of the herpes simplex virus-rabbit kidney cell system by the plaque technique. Virology 4, 435–457 (1957).

    PubMed  CAS  Google Scholar 

  • Kaplan, A. S.: Studies on the replicating pool of viral DNA in cells infected with Pseudorabies virus. Virology 24, 19–25 (1964).

    PubMed  CAS  Google Scholar 

  • Kaplan, A. S., and T. Ben-Porat: The effect of Pseudorabies virus on the nucleic acid metabolism and on the nuclei of rabbit kidney cells. Virology 8, 352–366 (1959).

    PubMed  CAS  Google Scholar 

  • Kaplan, A. S., and T. Ben-Porat: The incorporation of C14-labeled nucleosides into rabbit kidney cells infected with Pseudorabies virus. Virology 11, 12–27 (1960).

    PubMed  CAS  Google Scholar 

  • Kaplan, A. S., and T. Ben-Porat: The action of 5-fhiorouracil on the nucleic acid metabolism of Pseudorabies virus-infected and noninfected rabbit kidney cells. Virology 13, 78–92 (1961).

    PubMed  CAS  Google Scholar 

  • Kaplan, A. S., and T. Ben-Porat: The pattern of viral and cellular DNA synthesis in Pseudorabies virus-infected cells in the logarithmic phase of growth. Virology 19, 205–214 (1963).

    CAS  Google Scholar 

  • Kaplan, A. S., and T. Ben-Porat: Mode of replication of Pseudorabies virus DNA. Virology 23, 90–95 (1964).

    PubMed  CAS  Google Scholar 

  • Kaplan, A. S., and T. Ben-Porat: The replication of the double-stranded DNA of an animal virus during intracellular multiplication. Symposium Internat. Congr. of Microbiology, p. 463–482, Moscow 1966 a.

    Google Scholar 

  • Kaplan, A. S., and T. Ben-Porat: Mode of antiviral action of 5-iodouracil deoxyriboside. J. molec. Biol. 19, 320–332 (1966b).

    PubMed  CAS  Google Scholar 

  • Kaplan, A. S., T. Ben-Porat, and C. Coto: Studies on the control of the infective process in cells infected with Pseudorabies virus. In: Molecular biology of viruses, p. 527–545 (J. Colter, ed.). New York: Academic Press 1967.

    Google Scholar 

  • Kaplan, A. S., and A. E. Vatter: A comparison of herpes simplex and pseudo-rabies viruses. Virology 7, 394–407 (1959).

    PubMed  CAS  Google Scholar 

  • Kaufman, H. E.: The diagnosis of corneal herpes simplex infection by fluorescent antibody staining. Arch. Ophthal. 64, 382–384 (1960).

    PubMed  CAS  Google Scholar 

  • Keir, H. M.: DNA polymerases from mammalian cells. Prog. Nucleic Acid Res. Molec. Biol. vol. 4, p. 81–128 (J. N. Davidson and W. E. Cohn, eds.). New York: Academic Press 1965.

    Google Scholar 

  • Keir, H. M.: Virus-induced enzymes in mammalian cells infected with DNA-viruses. In: Molecular biology of viruses. XVIII Symp. Soc. Gen. Microbiol., p. 67–99. Cambridge, England: Cambridge University Press 1968.

    Google Scholar 

  • Keir, H. M., and E. Gold: Deoxyribonucleic acid nucleotidyltransferase and deoxyribo-nuclease from cultured cells infected with herpes simplex virus. Biochim. biophys. Acta (Amst.) 72, 263–276 (1963).

    CAS  Google Scholar 

  • Keir, H. M., J. Hay, J. M. Morrison, and H. Subak-Sharpe: Altered properties of deoxyribonucleic acid nucleotidyltransferase after infection of mammalian cells with herpes simplex virus. Nature (Lond.) 210, 369–371 (1966a).

    CAS  Google Scholar 

  • Keir, H. M., H. Subak-Sharpe, W. I. H. Shedden, D. H. Watson, and P. Wildy,: Immunological evidence for a specific DNA polymerase produced after infection by herpes simplex virus. Virology 30, 154–157 (1966b).

    PubMed  CAS  Google Scholar 

  • Kit, S., and D. R. Dubbs: Acquisition of thymidine kinase activity by herpes simplex infected mouse fibroblast cells. Biochem. biophys. Res. Commun. 11, 55–59 (1963a).

    CAS  Google Scholar 

  • Kit, S., and D. R. Dubbs: Non-functional thymidine kinase cistron in bromodeoxyuridine resistant strains of herpes simplex virus. Biochem. biophys. Res. Commun. 13, 500–504 (1963b).

    CAS  Google Scholar 

  • Klein, E., P. Clifford, G. Klein, and C. A. Hamberger: Further studies on the membrane immunofluorescence reaction of Burkitt lymphoma cells. Int. J. Cancer 2, 27–36 (1967a).

    PubMed  CAS  Google Scholar 

  • Klein, G., P. Clifford, E. Klein, and J. Stjernsward: Search for tumor-specific immune reactions in Burkitt lymphoma patients by the membrane immunofluorescence reaction. Proc. nat. Acad. Sci. (Wash.) 55, 1628–1635 (1966).

    CAS  Google Scholar 

  • Klein, G., E. Klein, and P. Clifford: Search for host defenses in Burkitt lymphoma membrane immunofluorescence tests on biopsies and tissue culture lines. Cancer Res. 27, 2510–2520 (1967b).

    PubMed  CAS  Google Scholar 

  • Klein, G., E. Klein, and P. Clifford: Host defenses in Leukemia and Burkitt’s tumor. Cancer (Philad.) 21, 587–594 (1968c).

    CAS  Google Scholar 

  • Klein, G., G. Pearson, G. Henle, W. Henle, V. Diehl, and J. Niederman C.: Relation between Epstein-Barr viral and cell membrane immunofluorescence in Burkitt tumor cells. II. Comparison of cells and sera from patients with Burkitt’s lymphoma and infectious mononucleosis. J. exp. Med. 128, 1021–1030 (1968b).

    PubMed  CAS  Google Scholar 

  • Klein, G., G. Pearson, J. S. Nadkarni, J. J. Nadkarni, E. Klein, G. Henle, W. Henle, and P. Clifford: Relation between Epstein-Barr viral and cell membrane immunofluorescence of Burkitt tumor cells. I. Dependence of cell membrane immunofluorescence on presence of EB virus. J. exp. Med. 128, 1011–1020 (1968a).

    CAS  Google Scholar 

  • Klemperer, H. G., G. R. Haynes, W. I. H. Shedden, and D. H. Watson: A virus-specific thymidine kinase in BHK-21 cells infected with herpes simplex virus. Virology 31, 120–128 (1967).

    PubMed  CAS  Google Scholar 

  • Kohlhage, H.: Differenzierung von Plaquevarianten des herpes simplex-virus durch Gradientenzentrifugation und Säulenchromatographie. Arch. ges. Virusforsch. 14, 358–365 (1964).

    PubMed  CAS  Google Scholar 

  • Kohlhage, H., u. G. Schieferstein: Untersuchungen über die genetische Stabilität des Plaque-bildes beim Herpes simplex-Virus in Zellkulturen. Arch. ges. Virusforsch. 15, 640–650 (1965).

    PubMed  CAS  Google Scholar 

  • Kohlhage, H., u. R. Siegert: Zwei genetisch determinierte Varianten eines Herpes simplex-Stammes. Arch. ges. Virusforsch. 12, 273–286 (1962).

    PubMed  CAS  Google Scholar 

  • Kvasnicka, A.: Relationship between herpes simplex and lip carcinoma. III. Neoplasma (Bratisl.) 10, 499–203 (1964).

    Google Scholar 

  • Kvasnicka, A.: Relationship between herpes simplex and lip carcinoma. IV. Selected cases. Neoplasma (Bratisl.). 12, 61–70 (1965).

    CAS  Google Scholar 

  • Lando, D., J. de Rudder et M. P. de Garilhe: Macromolecules et metabolites precurseurs a acides nucleiques. Bull. Soc. chim. Biol. (Paris) 47, 1033–1043 (1965).

    CAS  Google Scholar 

  • Lebrun, J.: E’tude de la localisation cellulaire du virus de Fherpes simplex par la methode des anticorps fluorescents. Extrait Bull. Micr. Appl. 2, 94–99 (1956a).

    Google Scholar 

  • Lebrun, J.: Cellular localization of herpes simplex virus by means of fluorescent antibody. Virology 2, 496–510 (1956b).

    PubMed  CAS  Google Scholar 

  • Lecatsas, G., and B. J. Erasmus: Electron microscopic study of the formation of African horse sickness virus. Arch. ges. Virusforsch. 22, 442–450 (1967).

    CAS  Google Scholar 

  • Lehane, D.E., H. F. Clark, and D. T. Karzon: Antigenic relationships among frog viruses demonstrated by the plaque reduction and neutralization kinetics tests. Virology 34, 590–595 (1968).

    PubMed  Google Scholar 

  • Levine, A. J., and H. S. Ginsberg: Biochemical studies on the mechanism by which the fiber antigen inhibits multiplication of type 5 adenovirus. J. Virol. 1, 747–757 (1967).

    PubMed  CAS  Google Scholar 

  • Levine, A. J., and H. S. Ginsberg: Role of adenovirus structural proteins in the cessation of host-cell biosynthetic functions. J. Virol. 2, 430–439 (1968).

    PubMed  CAS  Google Scholar 

  • Levy, H. B., and W. A. Carter: Molecular basis of the action of interferon. J. molec. Biol. 31, 561–577 (1968).

    PubMed  CAS  Google Scholar 

  • Lipschutz, B.: Untersuchungen über die Aetiologie der Krankheiten der Herpes-gruppe (herpes zoster, herpes genitalis, herpes febriles). Arch. Derm. Syph. (Berl.) 136, 428–482 (1921).

    Google Scholar 

  • Lipschutz, B.: Neurodermotrope Infektionen; in Handbuch der Haut und Geschlechtskrankheiten. Berlin: Springer 1932.

    Google Scholar 

  • Lunger, P. D.: The isolation and morphology of the Lücke frog kidney tumor virus. Virology 24, 138–145 (1964).

    PubMed  CAS  Google Scholar 

  • Lunger, P. D., R. W. Darlington, and A. Granoff: Cell-virus relationship in the Lucké renal adenocarcinoma: an ultrastructure study. Ann. N.Y. Acad. Sci. 126, 289–314 (1965).

    PubMed  CAS  Google Scholar 

  • Lwoff, A., R. Horne, and P. Tournier: A system of viruses. Cold Spr. Harb. Symp. quant. Biol. 27, 51–55 (1962).

    CAS  Google Scholar 

  • Lwoff, A., and P. Tournier: The classification of viruses. Amer. Rev. Microbiol. 20, 45–74 (1966).

    CAS  Google Scholar 

  • Marcus, P. I., and J. M. Salb: Molecular basis of interferon action: inhibition of viral RNA translation. Virology 30, 502–516 (1966).

    PubMed  CAS  Google Scholar 

  • Martin, W. B., D. Hay, L. V. Crawford, G. L. LeBouvier, and M. E. Crawford: Characteristics of bovine mammillitis virus. J. gen. Microbiol. 45, 325–332 (1966).

    PubMed  CAS  Google Scholar 

  • Mayor, H. D., S. E. Stevebaugh, R. M. Jamison, L. E. Jordan, and J. L. Mel-nick: Immunofluorescence, cytochemical and microcytological studies on the growth of simian vacuolating virus (SV-40) in tissue culture. Exp. molec. Path. 1, 397–416 (1962).

    PubMed  CAS  Google Scholar 

  • McAuslan, B. R.: Deoxyribonuclease activity of normal and poxvirus infected HeLa cells. Biochem. biophys. Res. Commun. 19, 15–20 (1965).

    CAS  Google Scholar 

  • McAuslan, B. R., P. Herde, D. Pett, and J. Ross: Nucleases of virus-infected animal cells. Biochem. biophys. Res. Commun. 20, 586–591 (1965).

    PubMed  CAS  Google Scholar 

  • McGavran, M. H., and M. C. Smith: Ultrastructural, cytochemical and micro-chemical observations on cytomegalovirus (salivary gland virus) infection of human cells in tissue culture. Exp. molec. Path. 4, 1–10 (1965).

    Google Scholar 

  • Meiselman, N., A. Kohn, and D. Danon: Electron microscopic study of penetration of newcastle disease virus into cells leading to formation of polykaryocytes. J. Cell Sci. 2, 71–76 (1967).

    PubMed  CAS  Google Scholar 

  • Melnick, J. L., M. Midulla, I. Wimberly, J. G. Barrera-Ora, and B. M. Levy: A new member of the herpesvirus group isolated from South American marmosets. J. Immunol. 92, 595–601 (1964).

    Google Scholar 

  • Mikharlova, G. R.: Action on the karyotype of man and animals. Genetica 7, 129–137 (1967).

    Google Scholar 

  • Mizell, M.: Introduction: state of the art. Proc. Symp. Biol. Amphibian Tumors. Berlin-Heidelberg-New York: Springer 1969 (in press).

    Google Scholar 

  • Morgan, C., S. A. Ellison, H. M. Rose, and D. H. Moore: Electron microscopic examination of inclusion bodies of herpes simplex virus. Proc. Soc. exp. Biol. (N.Y.) 82, 454–457 (1953).

    CAS  Google Scholar 

  • Morgan, C., S. A. Ellison, H. M. Rose, and D. H. Moore: Structure and development of viruses as observed in the electron microscope. I. Herpes simplex virus. J. exp. Med. 100, 195–202 (1954).

    CAS  Google Scholar 

  • Morgan, C., E. P. Jones, M. Holden, and H. M. Rose: Intranuclear crystals of herpes virus observed with the electron microscope. Virology 5, 568–571 (1958).

    PubMed  CAS  Google Scholar 

  • Morgan, C., and H. M. Rose: Adenoviruses and herpes simplex virus, with particular reference to intracellular crystals. 4th Internat. Conference on Electron Microscopy, vol. 2, p. 590–602. Berlin-Göttingen-Heidelberg: Springer 1960.

    Google Scholar 

  • Morgan, C., and H. M. Rose, M. Holden, and E. P. Jones: Electron microscopic observations on the development of herpes simplex virus. J. exp. Med. 110, 643–656 (1959).

    PubMed  CAS  Google Scholar 

  • Morgan, C., and H. M. Rose, and B. Mednis: Electron microscopy of herpes simplex virus. I. Entry. J. Virol. 2, 507–516 (1968).

    CAS  Google Scholar 

  • Morgan, J. F., H. J. Morton, and R. C. Parker: Nutrition of animal cells in tissue culture. I. Initial studies on a synthetic medium. Proc. Soc. exp. Biol. (N.Y.) 73, 1–8 (1950).

    CAS  Google Scholar 

  • Morris, V. L., and B. Roizman: Localization of frog virus multiplication in chick embryo cells by immunofluorescence. Proc. Soc. exp. Biol. (N.Y.) 124, 507–510 (1967).

    CAS  Google Scholar 

  • Morris, V. L., P. G. Spear, and B. Roizman: Some biophysical properties of frog viruses and their DNA. Proc. nat. Acad. Sci. (Wash.) 56, 1155–1157 (1966).

    CAS  Google Scholar 

  • Morrison, J. M., and H. M. Keir: Heat sensitive deoxyribonuclease activity in cells infected with herpes simplex virus. Biochem. J. 98, 37 (1966).

    Google Scholar 

  • Morrison, J. M., and H. M. Keir: Characterization of the deoxyribonuclease activity induced by infection with herpes virus. Biochem. J. 103, 70–71 (1967).

    Google Scholar 

  • Munk, K., and W.W.Ackermann: Some properties of herpes simplex virus. J. Immunol. 71, 426–430 (1953).

    PubMed  CAS  Google Scholar 

  • Munk, K., u. D. Donner: Cytopathischer Effekt und Plaque-Morphologie verschiedener Herpes-simplex-Virusstämme. Arch. ges. Virusforsch. 13, 529–540 (1963).

    PubMed  CAS  Google Scholar 

  • Munk, K., u. H. Fischer: Fluoreszenzimmunologische Unterschiede bei Herpes-simplex-Virusstämmen. Arch. ges. Virusforsch. 15, 539–548 (1965).

    Google Scholar 

  • Munk, K., and G. Sauer: Relationship between cell DNA metabolism and nucleocyto-plasmic alterations in herpesvirus-infected cells. Virology 22, 153–154 (1964).

    CAS  Google Scholar 

  • Munyon, W., and S. Kit: Inhibition of thymidine kinase formation in LM (TK~) cells simultaneously infected with vaccinia and a thymidine kinaseless vaccinia mutant. Virology 26, 374–377 (1966).

    Google Scholar 

  • Nahmias, A.: Proc. First Int. Congr. for Virology, Helsinki, Finland, in press (1968).

    Google Scholar 

  • Nahmias, A. J., and W. R. Dowdle: Antigenic and biologic differences in herpesvirus hominis. Prog. med. Virol. 10, in press (1968).

    Google Scholar 

  • Nahmias, A. J., and S. Kibrick: Inhibitory effect of heparin on herpes simplex virus. J. Bact. 87, 1060–1066 (1964).

    PubMed  CAS  Google Scholar 

  • Nahmias, A. J., S. Kibrick, and P. Bernfield: Effect of synthesis and biological polyanions on herpes simplex virus. Proc. Soc. exp. Biol. (N.Y.) 115, 993–996 (1964).

    CAS  Google Scholar 

  • Namhmias, A. J., M. Zuher, Z. M. Naib, W. E. Josey, and A. C. Clepper: Genital herpes simplex infection: virologie and cytologic studies. Obstet, and Gynec. 29, 395–400 (1967).

    Google Scholar 

  • Newton, A. A.: Synthesis of DNA in cells infected by virulant DNA viruses. In: Acid Nucleici e Lora Funzione Biologica, p. 109. Istituto Lombardo Accademia di Scienze e Lettere. Convegno Antomio Baselli (1964).

    Google Scholar 

  • Newton, A. A.: Proc. First Int. Congr. for Virology, Helsinki, Finland, in press (1968).

    Google Scholar 

  • Newton, A. A., P. P. Dendy, C. L. Smith, and P. Wildy: A pool size problem associated with the use of tritiated thymidine. Nature (Lond.) 194, 886–887 (1962).

    Google Scholar 

  • Newton, A. A., and M. G. P. Stoker: Changes in nucleic acid content of HeLa cells infected with herpes virus. Virology 5, 549–560 (1958).

    PubMed  CAS  Google Scholar 

  • Nichols, W. W.: One role of viruses in the etiology of chromosomal abnormalies. Amer. J. hum. Genet. 18, 81–92 (1966).

    PubMed  CAS  Google Scholar 

  • Nil, S., and J. Kamahora: Cytopathic changes induced by herpes simplex virus. Biken’s J. 4, 255–270 (1961).

    Google Scholar 

  • Nil, S., and J. Kamahora: High frequency appearance of amitotic nuclear divisions in PS cells induced by herpes simplex virus. Biken’s J. 6, 33–36 (1963a).

    Google Scholar 

  • Nil, S., and J. Kamahora: Location of herpetic viral antigen in interphase cells. Biken’s J. 6, 145–154 (1963b).

    Google Scholar 

  • Nil, S., C. Morgan, and H. M. Rose: Electron microscopy of herpes simplex virus. II. Sequence of development. J. Virol. 2, 517–536 (1968a).

    Google Scholar 

  • Nil, S., C. Morgan, H. M. Rose, and K. C. Hsu: Electron microscopy of herpes simplex virus. IV. Studies with ferritin-conjugated antibodies. J. Virol. 2, 1172–1184 (1968c).

    Google Scholar 

  • Nil, S., H. S. Rosenkranz, C. Morgan, and H. M. Rose: Electron microscopy of herpes simplex virus. III. Effect of hydroxyurea. J. Virol. 2, 1163–1171 (1968b).

    Google Scholar 

  • Nohara, H., and A. S. Kaplan: Induction of a new enzyme in rabbit kidney cells by Pseudorabies virus. Biochem. biophys. Res. Commun. 12, 189–193 (1963).

    CAS  Google Scholar 

  • O’Callaghan, D. J., W. P. Cheevers, G. A. Gentry, and C. C. Randall: Kinetics of cellular and viral DNA synthesis in equine abortion (herpes) virus infection of L-M cells. Virology 36, 104–114 (1968 a).

    PubMed  Google Scholar 

  • O’Callaghan, D. J., J. M. Hyde, G. A. Gentry, and C. C. Randall: Kinetics of viral deoxyribonucleic acid, protein and infectious particle production and alterations in host macromolecular synthesis in equine abortion (herpes) virus-infected cells. J. Virol. 2, 793–804 (1968b).

    PubMed  Google Scholar 

  • O’Conor, G. T., and A. S. Rabson: Herpes-like particles in an american lymphoma: preliminary note. J. nat. Cancer Inst. 35, 899–903 (1965).

    Google Scholar 

  • O’Dea, J. F., and J. K. Dineen: Fluorescent antibody studies with herpes simplex virus in unfixed preparations of trypsinized tissue cultures. J. gen. Microbiol. 17, 19–24 (1957).

    PubMed  Google Scholar 

  • Oshiro, L. S., H. M. Rose, C. Morgan, and K. C. Hsu: Electron microscopy study of the development of simian virus 40 by use of ferritin-labeled antibodies. J. Virol. 1, 384–399 (1967).

    PubMed  CAS  Google Scholar 

  • Piez, K. A., and H. Eagle: The free amino acid pool of cultured human cells. J. biol. Chem. 231, 533–545 (1958).

    PubMed  CAS  Google Scholar 

  • Plummer, G.: Serological comparison of the herpes viruses. Brit. J. exp. Path. 45, 135–141 (1964).

    PubMed  CAS  Google Scholar 

  • Plummer, G., and B. Lewis: Thermoinactivation of herpes simplex virus and cytomegalovirus. J. Bact. 89, 671–674 (1965).

    PubMed  CAS  Google Scholar 

  • Plummer, G. J. L. Waner, and C. P. Bowling: Comparative studies of type 1 and type 2 “herpes simplex” viruses. Brit. J. exp. Path. 49, 202–208 (1968).

    PubMed  CAS  Google Scholar 

  • Powell, W. F.: Radiosensitivity as an index of herpes simplex virus development. Virology 9, 1–19 (1959).

    PubMed  CAS  Google Scholar 

  • Prusoff, W. H., Y. S. Bakhle, and L. Sekely: Cellular and antiviral effects of halogenated deoxyribonucleosides. Ann. N.Y. Acad. Sci. 130, 135–150 (1965).

    PubMed  CAS  Google Scholar 

  • Rabin, E. R., A. B. Jenson, C. A. Phillips, and J. L. Melnick: Herpes simplex virus hepatitis in mice: an electron microscope study. Exp. molec. Path. 8, 34–48 (1968).

    PubMed  CAS  Google Scholar 

  • Rafferty, K. A., Jr.: The cultivation of inclusion-associated virus from Lucké tumor frogs. Ann. N.Y. Acad. Sci. 126, 3–21 (1966).

    Google Scholar 

  • Rafferty, K. A., Jr.: The biology of spontaneous renal carcinoma of the frog. Renal neoplasia, p. 301–315 (J. S. King, ed.). Boston: Little, Brown & Co. Inc. 1967.

    Google Scholar 

  • Rapp, F., and T. C. Hsu: Viruses and Mammalian chromosomes IV. Replication of herpes simplex virus in diploid hamster cells. Virology 25, 401–411 (1965).

    PubMed  CAS  Google Scholar 

  • Rapp, F., L. E. Rasmussen, and M. Benyesh-Melnick: The immunofluorescent focus technique in studying the replication of cytomegalovirus. J. Immunol. 91, 709–719 (1963).

    PubMed  CAS  Google Scholar 

  • Rawls, W. E., W. A. F. Tompkins, M. E. Figueroa, and J. L. Melnick: Herpesvirus type 2: association with carcinoma of the cervix. Science 161, 1255–1256 (1968).

    PubMed  CAS  Google Scholar 

  • Reissig, M., and A. S. Kaplan: The induction of amitotic nuclear division by Pseudorabies virus multiplying in single rabbit kidney cells. Virology 11, 1–11 (1960).

    Google Scholar 

  • Reissig, M., and A. S. Kaplan: The morphology of noninfective Pseudorabies virus produced by cells treated with 5-fluorouracil. Virology 16, 1–8 (1962).

    PubMed  CAS  Google Scholar 

  • Reissig, M., and J. L. Melnick: The cellular changes produced in tissue cultures by herpes B virus correlated with the concurrent multiplication of the virus. J. exp. Med. 101, 341–351 (1955).

    PubMed  CAS  Google Scholar 

  • Roane, P. R., Jr., and B. Roizman: Requirement for continuous protein synthesis for the development of resistance to UV light in HEp-2 cells infected with herpes simplex virus. Biochem. biophys. Acta (Amst.) 91, 168–170 (1964a).

    CAS  Google Scholar 

  • Roane, P. R., Jr., and B. Roizman: Studies of the determinant antigens of viable cells. II. Demonstration of altered antigenic reactivity of HEp-2 cells infected with herpes simplex virus. Virology 22, 1–8 (1964 b).

    Google Scholar 

  • Roane, P. R., Jr., and B. Roizman: Differentiation of nuclear and cytoplasmic herpesvirus antigens in infected cells. Virology 29, 668–670 (1966).

    PubMed  Google Scholar 

  • Roizman, B.: Virus infection of cells in mitosis. I. Observations on the recruitment of cells in karyokinesis into giant cells induced by herpes simplex virus and bearing on the site of virus antigen formation. Virology 13, 387–401 (1961).

    PubMed  CAS  Google Scholar 

  • Roizman, B.: Polykaryocytosis. Cold Spr. Harb. Symp. quant. Biol. 27, 327–342 (1962a).

    CAS  Google Scholar 

  • Roizman, B.: The role of hormones in viral infections. II. Acceleration of viral adsorption and penetration into cells treated with thyroid hormone in vitro. Proc. nat. Acad. Sci. (Wash.) 48, 973–977 (1962b).

    CAS  Google Scholar 

  • Roizman, B.: The role of hormones in viral infections. I. Suppression of viral adsorption and penetration into cells treated with parathyroid hormone in vitro. Proc. nat. Acad. Sci. (Wash.) 48, 795–803 (1962c).

    CAS  Google Scholar 

  • Roizman, B.: The programming of herpes virus multiplication in doubly-infected and in puro-mycin-treated cells. Proc. nat. Acad. Sci. (Wash.) 49, 165–171 (1963a).

    CAS  Google Scholar 

  • Roizman, B.: The programming of herpes virus multiplication in mammalian cells. Viruses, nucleic acids and cancer. Proc. of the 17th Annual Symp., p. 205–223, M. D. Anderson Hosp. and Tumor Inst. Baltimore: William Wilkins Company 1963b.

    Google Scholar 

  • Roizman, B.: Abortive infection of canine cells by herpes simplex virus. III. The interference of conditional lethal virus with an extended host range mutant. Virology 27, 113–117 (1965 a).

    PubMed  CAS  Google Scholar 

  • Roizman, B.: Extracellular pH and herpes simplex virus multiplication. Proc. Soc. exp. Biol. (N.Y.) 119, 1021–1023 (1965b).

    CAS  Google Scholar 

  • Roizman, B.: An Inquiry into the mechanisms of recurrent herpes infections of man. Perspectives in virology IV (M. Pollard, ed.), p. 283–304. New York: Harper & Row 1966 c).

    Google Scholar 

  • Roizman, B., and L. Aurelian: Abortive infection of canine cells by herpes simplex virus. I. Characterization of viral progeny from cooperative infection with mutants differing in ability to multiply in canine cells. J. molec. Biol. 11, 528 – 538 (1965).

    PubMed  CAS  Google Scholar 

  • Roizman, B., L. Aurelian, and P. R. Roane Jr.: The multiplication of herpes simplex virus. I. The programming of viral DNA duplication in HEp-2 cells. Virology 21, 482–498 (1963).

    PubMed  CAS  Google Scholar 

  • Roizman, B., G. S. Borman, and M. Kamali-Rousta: Macromolecular synthesis in cells infected with herpes simplex virus. Nature (Lond.) 206, 1374–1375 (1965).

    CAS  Google Scholar 

  • Roizman, B., and P. R. Roane Jr.: A physical difference between two strains of herpes simplex virus apparent on sedimentation in cesium chloride. Virology 15, 75–79 (1961 a).

    PubMed  CAS  Google Scholar 

  • Roizman, B., and P. R. Roane Jr.: Studies of the determinant antigens of viable cells. I. A method and its application in time culture studies for enumeration of killed cells based on the failure of virus multiplication following injury by cytotoxic antibody and complement. J. Immunol. 87, 714–727 (1961b).

    PubMed  CAS  Google Scholar 

  • Roizman, B., and P. R. Roane Jr.: Demonstration of a surface difference between virions of two strains of herpes simplex virus. Virology 19, 198–204 (1963).

    PubMed  CAS  Google Scholar 

  • Roizman, B., and P. R. Roane Jr.: The multiplication of herpes simplex virus. II. The relation between protein synthesis and the duplication of viral DNA in infected HEp-2 cells. Virology 22, 262–269 (1964).

    PubMed  CAS  Google Scholar 

  • Roizman, B., and P. G. Spear: Preparation of herpes simplex virus of high titer. J. Virol. 2, 83–84 (1968).

    PubMed  CAS  Google Scholar 

  • Roizman, B., and P. G. Spear: Viral infection and macromolecular biosynthesis of animal cells. Current topics in developmental biology, vol. 4. London and New York: Academic Press 1969 (in press).

    Google Scholar 

  • Roizman, B., and S. B. Spring: Alteration in immunologic specificity of cells infected with cytolytic viruses. Proc. Conf. on Cross Reacting Antigens and Neoantigens (J. J. Trentin, ed.), p. 85–96. Baltimore: William Wilkins & Co. 1967.

    Google Scholar 

  • Roizman, B., S. B. Spring, and P. R. Roane Jr.: Cellular compartmentalization of herpes virus antigens during viral replication. J. Virol. 1, 181–192 (1967).

    PubMed  CAS  Google Scholar 

  • Roizman, B., S. B. Spring, and J. Schwartz: The properties of the herpes virion and its precursor made in productively and abortively infected cells. Proc. symposium on viral defectiveness. Fed. Proc, in press (1969).

    Google Scholar 

  • Ross, L. J. N., D. H. Watson, and P. Wildy: Development and localization of virus-specific antigens during the multiplication of herpes simplex virus in BHK21 cells. J. gen. Virol. 2, 115–122 (1968).

    PubMed  CAS  Google Scholar 

  • Ross, R. W., and E. Orlans: The redistribution of nucleic acid and the appearance of specific antigen in HeLa cells infected with herpesvirus. J. Path. Bact. 76, 393–402 (1958).

    PubMed  CAS  Google Scholar 

  • Rouse, H. C., V. H. Bonifas, and R. W. Schlesinger: Dependence of adenovirus replication on arginine and inhibition of plaque formation by pleuropneumonia- like organisms. Virology 20, 357–365 (1963).

    CAS  Google Scholar 

  • Russell, W. C.: Herpes virus nucleic acid. Virology 16, 355–357 (1962).

    PubMed  CAS  Google Scholar 

  • Russell, W. C., and L. V. Crawford: Some characteristics of the deoxyribonucleic acid from herpes simplex virus. Virology 21, 353–361 (1963).

    PubMed  CAS  Google Scholar 

  • Russell, W. C., and L. V. Crawford: Properties of the nucleic acids from some herpes group viruses. Virology 22, 288–292 (1964).

    PubMed  CAS  Google Scholar 

  • Russell, W. C., E. Gold, H. M. Keir, H. Omura, D. H. Watson, and P. Wildy: The growth of herpes simplex virus and its nucleic acid. Virology 22, 103–110 (1964).

    CAS  Google Scholar 

  • Rustigan, R., J. B. Smulow, M. Tye, W. A. Gibson, and E. Shindell: Studies on latent infection of skin and oral mucosa in individuals with recurrent herpes simplex. J. invest. Derm. 47, 218–221 (1966).

    Google Scholar 

  • Sablina, O. V., and E. F. Bocharov: Chromosomal aberrations in the HeLa and HEp-2 tissue culture cells induced by herpes simplex virus. Genetika 4, 128–134 (1968).

    Google Scholar 

  • Saksela, E., and A. Vaheri: Absence of cell proliferation in proliferative CPE caused by herpes simplex virus. Scand. J. clin. Invest. 21, 50 (1968).

    Google Scholar 

  • Salzman, N. P.: The rate of formation of vaccinia deoxyribonucleic acid and vaccinia virus. Virology 10, 150–152 (1960).

    PubMed  CAS  Google Scholar 

  • Salzman, N. P., and E. D. Sebring: Sequential formation of vaccinia virus proteins and viral deoxyribonucleic acid replication. J. Virol. 1, 16–23 (1967).

    PubMed  CAS  Google Scholar 

  • Sauer, G., and K. Munk: Interference of actinomycin D with the replication of the DNA herpes virus. II. Relationship between yield of virus and time of actinomycin treatment. Biochim. Biophys. Acta (Amst.) 119, 341–346 (1966).

    CAS  Google Scholar 

  • Sauer, G., H. D. Orth, and K. Munk: Interference of actinomycin D with the replication of the herpes virus DNA. I. Difference in behavior of cellular and viral nucleic acid synthesis following treatment with actinomycin D. Biochim. Biophys. Acta (Amst.) 119, 331–340 (1966).

    CAS  Google Scholar 

  • Schiek, W.: Die Massendichte des Herpes simplex-Virus im Casiumchlorid-Wassergradienten. Beziehungen zur Plaquemorphologie auf HeLa-Zellen und zum serologischen Typ. Z. Immun.-Forsch. 132, 207–217 (1967).

    CAS  Google Scholar 

  • Schiek, W., u. K. E. Schneweiss: Beitrag zur Massen dichte von Plaquevarianten des Herpesvirus hominis im Caesiumchlorid-Wassergradient en. Arch. Ges. Virusforsch. 23, 280–283 (1968).

    PubMed  CAS  Google Scholar 

  • Schneweiss, K. E.: Serologische Untersuchungen zur Typendifferenzierung des Herpesvirus hominis. Z. Immuno-Forsch. 124, 24–48 (1962a).

    Google Scholar 

  • Schneweiss, K. E.: Der cytopatische Effekt des Herpes simplex-Virus. Zbl. Bakt., I. Abt. Orig. 186, 467–485 (1962b).

    Google Scholar 

  • Schwartz, J., and B. Roizman: Concerning the egress of herpes simplex virus from infected cells: electron and light microscope observations. Virology, in press (1969).

    Google Scholar 

  • Scott, T. F., C. F. Burgoon, L. L. Coriell, and H. Blank: The growth curve of the virus of herpes simplex in rabbit corneal cells grown in tissue culture with parallel observations on the development of the intranuclear inclusion body J. Immunol. 71, 385–396 (1953).

    PubMed  CAS  Google Scholar 

  • Scott, T. F., D. L. McLeod, and T. Tokumaru: A biologic comparison of two strains of herpesvirus hominis. J. Immunol. 86, 1–12 (1961).

    PubMed  CAS  Google Scholar 

  • Shedden, W. I. H., H. Subak-Sharpe, D. H. Watson, and P. Wildy: Immunological evidence for a specific DNA polymerase produced after infection by herpes simplex virus. Virology 30, 154–157 (1966).

    PubMed  Google Scholar 

  • Shipkey, F., R. Erlandson, R.Bailey, V. Babcock, and C. Southam: Virus Biographies. II. Growth of herpes simplex virus in tissue culture. Exp. molec. Path. 6, 39–67 (1967).

    PubMed  CAS  Google Scholar 

  • Siegert, R. S., and D. Falke: Electron microscopic investigation of the development of herpes hominis virus in culture cells. Arch. Ges. Virusforsch. 19, 230–249 (1966).

    PubMed  CAS  Google Scholar 

  • Siminoff, P.: The effect of 5-bromodeoxyuridine on herpes simplex infection of HeLa cells. Virology 24, 1–12 (1964).

    PubMed  CAS  Google Scholar 

  • Siminoff, P., and M. G. Menefee: Normal and 5-bromodeoxyuridine-inhibited development of herpes simplex virus. An electron microscope study. Exp. Cell Res. 44, 241 – 255 (1966).

    PubMed  CAS  Google Scholar 

  • Smith, K. O.: Physical and biological observations of herpes virus. J. Bact. 86, 999–1009 (1963).

    PubMed  CAS  Google Scholar 

  • Smith, K. O.: Relationship between the envelope and the infectivity of herpes simplex virus. Proc. Soc. exp. Biol. (N.Y.) 115, 814–816 (1964).

    CAS  Google Scholar 

  • Smith, K. O., and C. D. Dukes: Effects of 5-iodo-2-deoxyuridine (IDU) on herpesvirus synthesis and survival in infected cells. J. Immunol. 92, 550–554 (1964).

    PubMed  CAS  Google Scholar 

  • Soehner, R. L., G. A. Gentry, and C. C. Randall: Some psycho-chemical characteristics of equine abortion virus nucleic acid. Virology 26, 394–405 (1965).

    PubMed  CAS  Google Scholar 

  • Sokolov, M. I., A. V. Germanov, and L. S. Ratushkina: Obtaining of herpes virus mutants resistant to dextran sulfate. Probl. Virol. (N.Y.) 3, 363–372 (1967).

    Google Scholar 

  • Spear, P. G., and B. Roizman: Buoyant density of herpes simplex virus in solutions of cesium chloride. Nature (Lond.) 214, 713–714 (1967).

    CAS  Google Scholar 

  • Spear, P. G., and B. Roizman: The proteins specified by herpes simplex virus. I. Time of synthesis, transfer into nuclei, and properties of proteins made in productively infected cells. Virology 36, 545–555 (1968)

    PubMed  CAS  Google Scholar 

  • Speck, R. S., S. E. Jowetz, and V. R. Coleman: Studies on herpes simplex virus. I. The stability and preservation of egg-adapted herpes simplex virus. J. Bact 61, 253–258 (1951).

    PubMed  CAS  Google Scholar 

  • Spring, S. B., and B. Roizman: Herpes simplex virus products in productive and abortive infection. I. Stabilization with formaldehyde and preliminary analyses by isopycnic centrifugation in CsCl. J. Virol. 1, 294–301 (1967).

    PubMed  CAS  Google Scholar 

  • Spring, S. B., and B. Roizman: Herpes simplex virus products in productive and abortive infection. III. Differentiation of infectious virus derived from nucleus and cytoplasm with respect to stability and size. J. Virol. 2, 979–985 (1968).

    PubMed  CAS  Google Scholar 

  • Spring, S. B., B. Roizman, and J. Schwartz: Herpes simplex virus products in productive and abortive infection. J. Virol. 2, 384–392 (1968).

    PubMed  CAS  Google Scholar 

  • Stackpole, C. W., and M. Mizell: Electron microscopic observations of herpestype virus-related structures in frog renal adenocarcinoma. Virology 36, 63–72 (1968).

    PubMed  CAS  Google Scholar 

  • Stevens, J. G., and N.B. Groman: Properties of infectious bovine rhinotracheitis virus in a quantitated virus-cell culture system. Amer. J. vet. Res. 24, 1158–1163 (1963).

    PubMed  CAS  Google Scholar 

  • Stevens, J. G., and N. L. Jackson: Studies on a temperature-sensitive step essential to herpesvirus DNA replication. Virology 32, 654–661 (1967).

    PubMed  CAS  Google Scholar 

  • Stewart, S. E., E. Lovelace, J. J. Whang, G. Ngu, and V. Anomah: Burkitt tumor: tissue culture, cytogenetic and virus studies. J. nat. Cancer Inst. 34, 319–327 (1965).

    PubMed  CAS  Google Scholar 

  • Stich, H. F., T. C. Hsu, and F. Rapp: Viruses and mammalian chromosomes. I. Localization of chromosome aberrations after infection with herpes simplex virus. Virology 22, 439–445 (1964).

    PubMed  CAS  Google Scholar 

  • Stich, H. F.,K. M. Smith, and R. W. Ross: Electron microscope studies of HeLa cells infected with herpes virus. J. gen. Microbiol. 19, 244–249 (1958).

    Google Scholar 

  • Stoker, M. G. P.: Growth studies with herpes virus. 9th Symp. Soc. Gen. Microbiol., p. 142–170. Cambridge, England: Cambridge University Press (1959).

    Google Scholar 

  • Stoker, M. G. P.,and A.A. Newton: Mitotic inhibition in HeLa cells caused by herpes virus. Ann. N.Y. Acad. Sci. 81, 129–132 (1959).

    PubMed  CAS  Google Scholar 

  • Stoker, M. G. P., and R. W. Ross: Quantitative studies on the growth of herpes virusin HeLa cells. J. gen. Microbiol. 19, 250–266 (1958).

    PubMed  CAS  Google Scholar 

  • Subak-Sharpe, H.: Virus-induced changes in translation mechanisms. In: The molecular biology of viruses (L. V. Crawford and M. G. P. Stoker, eds.), p. 47–66. Cambridge, England: Cambridge University Press (1968).

    Google Scholar 

  • Subak-Sharpe, H., and J. Hay: An animal virus with DNA of high guanine and cytosine content which codes for sRNA. J. molec. Biol. 12, 924–928 (1965).

    PubMed  CAS  Google Scholar 

  • Subak-Sharpe, H., W. M. Shepherd, and J. Hay: Studies on sRNA coded by herpes virus. Cold Spr. Harb. Symp. quant. Biol. 31, 583–594 (1966).

    CAS  Google Scholar 

  • Sydiskis, R. J., and B. Roizman: Polysomes and protein synthesis in cells infected with a DNA virus. Science 153, 76–78 (1966).

    PubMed  CAS  Google Scholar 

  • Sydiskis, R. J., and B. Roizman: The disaggregation of host polyribosomes in productive and abortive infection with herpes simplex virus. Virology 32, 678–686 (1967).

    PubMed  CAS  Google Scholar 

  • Sydiskis, R. J., and B. Roizman: The sedimentation profiles of cytoplasmic polyribosomes in mammalian cells productively and abortively infected with herpes simplex virus. Virology 34, 562–565 (1968).

    PubMed  CAS  Google Scholar 

  • Takemoto, K. K., and P. Fabish: Inhibition of herpes virus by natural and synthetic polysaccharides. Proc. Soc. exp. Biol. (N.Y.) 116, 140–144 (1964).

    CAS  Google Scholar 

  • Tanaka, S., and C. M. Southam: Joint action of herpes simplex virus and 3-methy-cholanthrene in production of papilomas in mice. J. nat. Cancer Inst. 34, 441–451 (1965).

    PubMed  CAS  Google Scholar 

  • Tankersley, R. W., Jr.: Amino acid requirements of herpes simplex virus in human cells. J. Bact. 87, 609–613 (1964).

    PubMed  CAS  Google Scholar 

  • Tänzer, J., M. Thomas, Y. Stoitchkov, M. Boiron, and J. Bernard: Alterations chromosomiques observées dans des cellules de rein de singe infected in vitro par le virus de l’herpès. Ann. Inst. Pasteur 107, 366–373 (1964).

    Google Scholar 

  • Taverne, J., and P. Wildy: Purification of herpes simplex virus by chromatography of calcium phosphate. Nature (Lond.) 184, 1655–1656 (1959).

    CAS  Google Scholar 

  • Terni, M.: 1/infezione erpetica recidivante: conoscenze e problemi. Arcisped. S. Anna Ferrara 18, 515–532 (1965).

    PubMed  CAS  Google Scholar 

  • Tokumaru, T.: Psuedorabies virus in tissue culture: differentiation of two distinct strains of virus by cytopathogenic pattern induced. Proc. Soc. exp. Biol. (N. Y.) 96, 55–60 (1957).

    CAS  Google Scholar 

  • Tokumaru, T.: Studies of herpes simplex virus by the gel diffusion technique. I. Distribution of precipitating antibodies among human sera. J. Immunol. 95, 181–188 (1965 a).

    PubMed  CAS  Google Scholar 

  • Tokumaru, T.: Studies of herpes simplex virus by the gel diffusion technique. II. The characterization of viral and soluble precipitating antigens. J. Immunol. 95, 189–195 (1965b).

    PubMed  CAS  Google Scholar 

  • Toplin, I., P. M. Brandt, and P. Sottong: The density gradient centrifugation studies on the herpes-type virus of the Lucké tumor. Proc. Symp. on Biology of Amphibian Tumors. Berlin-Heidelberg-New York: Springer 1969 (in press).

    Google Scholar 

  • Toplin, I., and G. Schidlovsky: Partial purification and electron microscopy of virus in the EB-3 cell line derived from a Burkitt lymphoma. Science 152, 1084–1085 (1966).

    PubMed  CAS  Google Scholar 

  • Tweedell, K. S.: Induced oncogenesis in developing frog kidney cells. Cancer Res. 27, 2042–2052 (1967).

    Google Scholar 

  • Tytell, A. A., and R. F. Neuman: A medium free of agar, serum and peptone for plaque assay of herpes simplex virus. Proc. Soc. exp. Biol. (N. Y.) 113, 343–346 (1963).

    CAS  Google Scholar 

  • Vaheri, A.: Heparin and related polyonic substances as virus inhibitors. Acta path, microbiol. scand. 171, Suppl. (1964).

    Google Scholar 

  • Vaheri, A., and K. Cantell: The effect of heparin on herpes simplex virus. Virology 21, 661–662 (1963).

    PubMed  CAS  Google Scholar 

  • Vaheri, A., and K. Penttinen: Effect of polyphloroglucinol phosphate, an acid polymer, on herpes simplex virus. Ann. Med. exp. Fenn. 40, 334–341 (1962).

    PubMed  CAS  Google Scholar 

  • Vantis, J. T., and P. Wildy: Interaction of herpes virus and HeLa cells: comparison of cell killing and infective center formation. Virology 17, 225–232 (1962).

    Google Scholar 

  • Vozza, R., and D. Balducci: The technique of fluorescent antibodies in ophthalmology; a study of herpes simplex and vaccine kerato conjunctivites and human trachomatous infection. Amer. J. Ophthal. 52, 72–77 (1961).

    PubMed  CAS  Google Scholar 

  • Wallis, C., and J. L. Melnick: Thermostabilization and thermosensitization of herpesvirus. J. Bact. 90, 1632–1637 (1965).

    PubMed  CAS  Google Scholar 

  • Wallis, C., and J. L. Melnick: Stabilization of enveloped virus by dimethyl sulfoxide. J. Virol. 2, 953–954 (1968).

    PubMed  CAS  Google Scholar 

  • Wallis, C., C. S. Yang, and J. L. Melnick: Effect of cations on thermal inactivation of vaccinia, herpes simplex and adenoviruses. J. Immunol. 89, 41–46 (1962).

    PubMed  CAS  Google Scholar 

  • Watkins, J. F.: Adsorption of sensitized sheep erythrocytes to HeLa cells infected with herpes simplex virus. Nature (Lond.) 202, 1364–1365 (1964).

    CAS  Google Scholar 

  • Watson, D.H.: The structure of animal viruses in relation to their biological functions. Symp. Soc. gen. Microbiol. 18, 207–229 (1968).

    CAS  Google Scholar 

  • Watson, D.H., W. I. H. Shedden, A. Elliot, T. Tetsuka, P. Wildy, D. Bourgaux-Ramoisy, and E. Gold: Virus specific antigens in mammalian cells infected with herpes simplex virus. Immunology 11, 399–408 (1966).

    PubMed  CAS  Google Scholar 

  • Watson, D. H., and P. Wildy: Some serological properties of herpes virus particles studied with electron microscope. Virology 21, 100–111 (1963).

    PubMed  CAS  Google Scholar 

  • Watson, D. H., and P. Wildy, and W. C. Russell: Quantitative electron microscope studies on the growth of herpes virus using the techniques of negative staining and ultramicrotomy. Virology 24, 523–538 (1964).

    PubMed  CAS  Google Scholar 

  • Waubke, R., H. zur Hausen, and W. Henle: Chromosomal and autoradiographic studies of cells infected with herpes simplex virus. J. Virol. 2, 1047–1054 (1968).

    PubMed  CAS  Google Scholar 

  • Weller, T. H., and J. R. Hanshaw: Virologic and clinical observations on cytomegalic inclusion disease. New Engl. J. Med. 266, 1233–1234 (1962).

    PubMed  CAS  Google Scholar 

  • Wheeler, C. E.: Biologic comparison of a syncytial and a small giant cell-forming strain of herpes simplex. J. Immunol. 93, 749–756 (1964).

    PubMed  Google Scholar 

  • Wight, P. A. L., J. E. Wilson, J. G. Campbell, and E. Fraser: Virus-like particles in blood lymphocytes in acute Marek’s disease. Nature (Lond.) 216, 804–805 (1967).

    CAS  Google Scholar 

  • Wildy, P., W. C. Russell, and R. W. Horne: The morphology of herpes virus. Virology 12, 204–222 (1960).

    PubMed  CAS  Google Scholar 

  • Wilner, I.B.: A classification of the major groups of human and other animal viruses, 3rd ed., p. 7S. Minneapolis, Minnesota: Burgess Publ. Co. 1966.

    Google Scholar 

  • Wyburn-Mason, R.: Malignant change following herpes simplex. Brit. med. J. 1957 II, 615–616.

    Google Scholar 

  • Yamaguchi, J., Y. Hinuma, and J.T.Grace Jr.: Structure of virus particles extracted from a Burkitt lymphoma cell line. J. Virol. 1, 640–642 (1967).

    PubMed  CAS  Google Scholar 

  • Zambernard, J., and M. Mizell: Viral particles of the frog renal adenocarcinoma: causative agent or passenger virus. I. Fine structure of primary tumors and subsequent intracellular transplants. Ann. N.Y. Acad. Sci. 126, 127–145 (1965).

    PubMed  CAS  Google Scholar 

  • Zambernard, J., and A. E. Vatter: The fine structural cytochemistry of virus particles found in renal tumors of leopard frogs. I. An enzymatic study of the viral nucleoid. Virology 28, 318–324 (1966).

    PubMed  CAS  Google Scholar 

  • Zemla, J., C. Coto, and A. S. Kaplan: Correlation between loss of enzymatic activity and of protein from cells infected with Pseudorabies virus. Virology 31, 736–738 (1967).

    PubMed  CAS  Google Scholar 

  • Zinsser, H., and F. F. Tang: Further experiments on agents of herpes. J. Immunol. 17, 343–355 (1929).

    Google Scholar 

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  1. Department of Microbiology, The University of Chicago, Chicago, Illinois, 60637, USA

    Bernard Roizman

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  1. Genève, Switzerland

    W. Arber

  2. New Brunswick, USA

    W. Braun

  3. Göttingen, Germany

    F. Cramer

  4. Freiburg, Germany

    R. Haas

  5. Philadelphia, USA

    W. Henle  & H. Koprowski  & 

  6. München, Germany

    P. H. Hofschneider

  7. Basel, Switzerland

    N. K. Jerne

  8. Prague, Czech Republic

    P. Koldovsky  & L. Syruček  & 

  9. Copenhagen, Denmark

    O. Maaløe

  10. Gießen, Germany

    R. Rott

  11. Wilhelmshaven, Germany

    H.-G. Schweiger

  12. Rehovoth, Israel

    M. Sela

  13. Seattle, USA

    P. K. Vogt

  14. Würzburg, Germany

    E. Wecker

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Roizman, B. (1969). The Herpesviruses — A Biochemical Definition of the Group. In: Arber, W., et al. Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung. Current Topics in Microbiology and Immunology, vol 49. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46166-8_1

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