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Serum Inhibitors of Myxoviruses

  • Conference paper

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 47))

Abstract

The term “serum inhibitors of myxoviruses” has been used to designate proteinaceous substances differing from antibody and occurring in animal sera. These substances prevent agglutination of red blood cells by myxoviruses and at least some of them also inhibit reproduction of myxoviruses in susceptible cells.

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References

  • Alexandrova, G. I.: An analysis of the structure of the populations of inhibitor-sensitive and inhibitor-resistant A2 influenza virus strains. Acta virol. 6, 487–497 (1962).

    Google Scholar 

  • Ananthanaryan, R., and C. J. K. Paniker: Non-specific inhibitors of influenza viruses in normal sera. Bull. Wld Hlth Org. 22, 409–420 (1960).

    Google Scholar 

  • Anderson, S. G.: Mucins and mucoids in relation to influenza virus action. Aust. J. exp. Biol. med. Sci. 26, 347–411 (1948).

    PubMed  CAS  Google Scholar 

  • Bang, F. B., M. Foard, and D. T. Karzon: The determination and significance of substances neutralizing Newcastle Virus in human serum. Johns Hopk. Hosp. Bull. 87, 130–143 (1950).

    CAS  Google Scholar 

  • Bartolomei-Corsi, O., A. M. Casazza, A. di Marco, M. Ghione, and A. Zanella: Biological properties of a horse serum inhibitor against influenza A2 viruses. In VIIIth Int. Congr. Microbiol., Abstracts, Montreal, Quebec, Canada, No. D. 30. 5p. 96(1962).

    Google Scholar 

  • Bayer, M. E.: The reaction of receptor glycoprotein with influenza virus and neuraminidase. An electron microscopic study. Trans. N.Y. Acad. Sci. 26, Suppl. 1103–1111 (1965).

    Google Scholar 

  • Belyavin, G.: The mechanism of influenza virus haemagglutination as a model of specific receptor adsorption. J. gen. Microbiol. 32, 15–18 (1963).

    PubMed  CAS  Google Scholar 

  • Belyavin, G., and A. Cohen: Chromatography of influenza virus haemagglutination inhibitors. Virology 18, 144–145 (1962).

    PubMed  CAS  Google Scholar 

  • Biddle, F., D. S. Pepper, and G. Belyavin: Properties of horse serum gamma inhibitor. Nature (Lond.) 207, 381–383 (1965).

    CAS  Google Scholar 

  • Biddle, F., and K. F. Shortridge: Immunological cross-reactions of influenza virus inhibitors. Brit. J. exp. Path. 48, 285–293 (1967).

    Google Scholar 

  • Biddle, F., and J. P. Stevenson: Flocculation of influenza viruses by horse serum inhibitor. Nature (Lond.) 209, 1223–1225 (1966).

    CAS  Google Scholar 

  • Blaškovič, D., N. A. Maximovič, B. Styk, and P. Albrecht: Course of adaptation of the inhibitor-resistant influenza virus A2 to ferrets. Čs. Epidem. 10, 158–165 (1961) [in Slovak].

    Google Scholar 

  • Borecký, L.: A factor destroying virus receptors in pneumococcal cultures. I. Isolation and properties of the factor. Acta virol. 2, 73–83 (1958).

    PubMed  Google Scholar 

  • Borecký, L.: Mechanisms of nonspecific resistance of the organism. Bratislava, Vydavatel’stvo Slovenskej akadémie vied 1967 [in Slovak].

    Google Scholar 

  • Borecký, L., S. Halperen, and W. W. Ackermann: Comparative study of the interaction of polyoma and other hemagglutinating viruses with an isolated bovine mucoprotein. J. Immunol. 89, 752–758 (1962a).

    PubMed  Google Scholar 

  • Borecký, L., D. Kočišková, and L. Hána: An attempt to affect the level of serum inhibitors of myxoviruses in vivo. I. Effect of ethionine administration on the level of inhibitors in guinea-pig sera. Acta virol. 5, 236–244 (1961).

    Google Scholar 

  • Borecký, L., V. Lackovič, and V. Rathová: Surface properties of the egg and mouse lines of Al influenza virus. J. Immunol. 95, 387 (1965).

    PubMed  Google Scholar 

  • Borecký, L., V. Lackovič, and V. Rathová, and E. Mrena: The syndrome of adaptation of influenza viruses to laboratory animals. J. Hyg. Epidem. (Praha) 10, 277–287 (1966).

    Google Scholar 

  • Borecký, L., and V. Rathová: Investigations of possible cross reactions between preparations of Salmonellae containing Vi antigen and inhibitors or antibodies against myxoviruses. Acta virol. 7, 339–349 (1963b).

    Google Scholar 

  • Borecký, L., and V. Rathová, and D. Kočišková: An attempt to affect the level of serum inhibitors of myxoviruses in vivo. II. Effect of ethionine administration on virus multiplication. Acta virol. 6, 97–104 (1962 c).

    Google Scholar 

  • Borecký, L., and V. Rathová, and D. Kočišková, and L. Hána: Effect of d-1 ethionine on some factors of nonspecific resistance to myxoviruses. J. Hyg. Epidem. (Praha) 6, 65–70 (1962b).

    Google Scholar 

  • Borecký, L., and V. Rathová, and O. Križanová: Nonspecific resistance of the organism and myxovirus inhibitors. (Comparison of some antibacterial and antiviral mechanisms.) Folia microbiol. (Praha) 8, 137–146 (1963 a).

    Google Scholar 

  • Boretti, G., A. Di Marco, and J. Piera: Preparation and characterization of an influenza virus inhibitor from horse serum. G. Microbiol. 12, 55–70 (1964).

    CAS  Google Scholar 

  • Bowarnick, M., and P. M. de Burgh: Virus haemagglutination. Science 105, 550 (1947).

    Google Scholar 

  • Brans, L. M., E. Hertzberger, and J. L. Binkhorst: Studies on the elimination of nonspecific inhibitor in sera against influenza viruses with the aid of filtrates of Vibrio Cholerae. Antonie v. Leeuwenhoek 19, 309 (1953).

    CAS  Google Scholar 

  • Briody, B. A.: Antigenic mutants of influenza virus. Fed. Proc. 16, 407–408 (1957).

    Google Scholar 

  • Briody, B. A., and W. A. Cassel: Adaptation of influenza virus to mice. I. Changes in the growth curve of an A prime strain of influenza virus. J. Immunol. 74, 37–40 (1955b).

    PubMed  CAS  Google Scholar 

  • Briody, B. A., and W. A. Cassel, and M. A. Medill: Adaptation of influenza virus to mice. III. Development of resistance to beta-inhibitor. J. Immunol. 74, 41–45 (1955 a).

    PubMed  CAS  Google Scholar 

  • Bürgi, W., and K. Schmid: Preparation and properties of Zn-alfa2-glycoprotein of normal human plasma. J. biol. Chem. 236, 1066–1077 (1961).

    PubMed  Google Scholar 

  • Burnet, F. M., and J. D. Stone: The receptor-destroying enzyme of V. Cholerae. Aust. J. exp. Biol. med. Sci. 25, 227–235 (1947).

    PubMed  CAS  Google Scholar 

  • Burnet, J. M.: The effect of periodate on the virus inhibitory qualities of mucoids in solution. Aust. J. exp. Biol. med. Sci. 27, 218 (1949).

    Google Scholar 

  • Burnet, J. M., and J. F. McCrea: Inhibitory and inactivating action of normal ferret sera against an influenza virus strain. Aust. J. exp. Biol. med. Sci. 24, 277–282 (1946).

    PubMed  CAS  Google Scholar 

  • Casazza, A. M., A. di Marco, M. Ghione, and A. Zanella: Biological properties of a horse serum inhibitor against influenza A2 viruses. G. Microbiol. 12, 1–14 (1964).

    CAS  Google Scholar 

  • Choppin, P. W., and W. Stoeckenius: Interactions of ether-disrupted influenza A2 virus with erythrocytes, inhibitors, and antibodies. Virology 22, 482–492 (1964).

    PubMed  CAS  Google Scholar 

  • Choppin, P. W., and I. Tamm: Two kinds of particles with contrasting properties in influenza A virus strains from the 1957 pandemic. Virology 8, 539–542 (1959).

    PubMed  CAS  Google Scholar 

  • Choppin, P. W., and W. Stoeckenius: Studies of two kinds of virus particles which comprise influenza A2 virus strains. II. Reactivity with virus inhibitors in normal sera. J. exp. Med. 112, 921–944 (1960a).

    PubMed  CAS  Google Scholar 

  • Choppin, P. W., and W. Stoeckenius: Studies of two kinds of virus particles which comprise influenza A2 virus strains. I. Characterization of stable homogeneous substrains in reactions with specific antibody, mucorpotein inhibitors and erythrocytes. J. exp. Med. 112, 895–920 (1960b).

    PubMed  CAS  Google Scholar 

  • Chu, C. M.: The action of normal mouse serum on influenza virus. J. gen. Microbiol. 5, 739–757 (1951).

    PubMed  CAS  Google Scholar 

  • Cohen, A.: Protection of mice against Asian influenza virus infection by a normal horse serum inhibitor. Lancet 1960b II, 791–794.

    Google Scholar 

  • Cohen, A., and G. Belyavin: Hemagglutination inhibition of Asian influenza viruses: A new pattern of response. Virology 7, 59–74 (1959).

    PubMed  CAS  Google Scholar 

  • Cohen, A., and G. Belyavin: The influenza virus hemagglutination inhibitors of normal rabbit serum. I. Separation of the inhibitory components. Virology 13, 58–67 (1961).

    PubMed  CAS  Google Scholar 

  • Cohen, A., and G. Belyavin, and E. Newland: Analysis of the horse serum inhibitor of A2 influenza virus haemagglutination and infectivity. VIIIth Int. Congr. Microbiol., Montreal, Quebec, Canada, No. D. 30. 4, p. 95 (1962).

    Google Scholar 

  • Cohen, A., and F. Biddle: The effect of passage in different hosts on the inhibitor sensitivity of an Asian influenza virus strain. Virology 11, 458–473 (1960a).

    PubMed  CAS  Google Scholar 

  • Cohen, A., and F. Biddle: Haemagglutination inhibition. Interaction of influenza viruses with horse serum inhibitor. Nature (Lond.) 198, 508–509 (1963b).

    CAS  Google Scholar 

  • Cohen, A., and F. Biddle, and S. E. Newland: Analysis of horse serum inhibitors of A2 influenza virus haemagglutination. Brit. J. exp. Path. 46, 497–513 (1965a).

    PubMed  CAS  Google Scholar 

  • Cohen, A., and J. Dorman: Non-specific inhibitors of A2 influenza virus in human sera. Actavirol. 9, 519–525 (1965b).

    CAS  Google Scholar 

  • Cohen, A., S. E. Newland, and F. Biddle: Inhibition of influenza virus haemagglutination: A difference of behavior in sera from a single species. Virology 20, 518–529 (1963 a).

    PubMed  CAS  Google Scholar 

  • Davoli, R., and O. Bartolomei-Corsi: Nonspecific inhibition of the haemagglutination by influenza viruses. VI. Haemagglutination-inhibition and neutralization of infectivity of influenza viruses of the type A2 by normal guinea pig serum activated by heat. Sperimentale 109, 32–42 (1959).

    Google Scholar 

  • Dawson, P. S.: The nature of substances present in normal bovine sera inhibiting the activity of parainfluenza 3 virus. J. comp. Path. 73, 428–436 (1963).

    PubMed  CAS  Google Scholar 

  • Expert committee on respiratory virus diseases. Wld Hlth Org. techn. Rep. Ser., No 170 (1959).

    Google Scholar 

  • Fauconnier, B., R. M.Lartitégui et D. Barua: Adaptation artificielle du virus grippal aux inhibiteurs du serum normal. I. Obtention, à partir d’une souche sensible d’une variante insensible par culture du virus en présence de son inhibiteur. Ann. Inst. Pasteur 97, 473–478 (1959).

    CAS  Google Scholar 

  • Fiset, P.: Serological techniques. In: Techniques in experimental virology. London and New York: R. J. C. Harris 1964.

    Google Scholar 

  • Francis, T., Jr.: Dissociation of hemagglutinating and antibody measuring capacities of influenza virus. J. exp. Med. 85, 1–7 (1947).

    PubMed  CAS  Google Scholar 

  • Fridman, E. A.: Non-specific neutralization of influenza virus and methods for its removal. Thesis Leningrad 1955 [in Russian].

    Google Scholar 

  • Füresz, J.: Studies on inhibitors of influenza virus haemagglutination in normal rabbit and ferret sera. Canad. J. Microbiol. 5, 505–511 (1959).

    Google Scholar 

  • Gamburg, V. P.: Haemagglutination inhibitor and neutralizing factor of A2 influenza virus in sera. Acta virol. 5, 317–324 (1961).

    Google Scholar 

  • Geft, R. A., and R. Ya. Polyak: Removal of thermostable inhibitors against A2 influenza virus from immune horse sera by rivanol. Acta virol. 7, 91 (1963).

    CAS  Google Scholar 

  • Gibbons, R. A.: The sensitivity of the neuraminosidic linkage in mucosubstances towards acid and towards neuraminidase. Biochem. J. 89, 380–391 (1963).

    PubMed  CAS  Google Scholar 

  • Ginsberg, H., and R. J. Wedgwood: Properdin and the inactivation of viruses. Ann. N.Y. Acad. Sci. 83, 528–532 (1960).

    PubMed  CAS  Google Scholar 

  • Ginsberg, H. S., and F. L. Horsfall: A labile component of normal serum which combines with various viruses. Neutralization of infectivity and inhibition of hemagglutination by the component. J. exp. Med. 90, 475–495 (1949).

    PubMed  CAS  Google Scholar 

  • Gorbunova, A. S., V. M. Stakhanova, A. N. Lozhkina, and V. D. Olli: Comparative efficacy of methods for treatment of sera with carbon dioxide, V. Cholerae filtrate and potassium periodate for eliminating unspecific inhibitors of hemagglutination to influenza A2 virus. Vop. Virus. 4, 750–753 (1959) [in Russian].

    PubMed  CAS  Google Scholar 

  • Gorev, N. E.: The use of broth culture filtrates of Pseudomonas fluorescens for the destruction of non-specific thermostabile (at 56° C) influenza virus inhibitor in human sera. Acta virol. 2, 171–178 (1958).

    PubMed  CAS  Google Scholar 

  • Gottschalk, A.: Chemistry of virus receptors. In: The viruses (F. M. Burnet and W. M. Stanley). New York and London 1959.

    Google Scholar 

  • Gottschalk, A.: The chemistry and biology of sialic acids and related substances. Cambridge 1960.

    Google Scholar 

  • Hána, L.: Some properties of haemagglutination inhibitor against influenza C virus. Proc. of the IVth Int. Congr. Biochem. Vienna 1958, 7, Sympos. 7, 160–162 (1958).

    Google Scholar 

  • Hána, L.: Non-specific inhibitors of myxoviruses. Zprávy z epidemiol. a mikrobiol. 5, 40–43 (1963a) [in Slovak].

    Google Scholar 

  • Hána, L., and B. Styk: Influence of delipidisation on the haemagglutination inhibiting activity of rat serum against influenza typ C viruses. Acta virol. 4, 392–393 (1960b).

    Google Scholar 

  • Hána, L., and B. Styk: Lipoids as inhibitors of heamagglutination-inhibiting activity against “avid” of A2 influenza. Acta virol. 5, 190–192 (1961).

    Google Scholar 

  • Hána, L., and B. Styk: An attempt to differentiate beta-inhibitor from cofactor occurring in bovine serum. Acta virol. 6, 77–83 (1962).

    PubMed  Google Scholar 

  • Hána, L., and B. Styk, and D. Kočišková: Estimation of the distribution and the character of inhibitors against “avid” A2 influenza virus strains in protein fractions of guinea pig and horse sera obtained by paper electrophoresis. Acta virol. 4, 356–364 (1960a).

    Google Scholar 

  • Hána, L., and B. Styk, and Š. Schramek: Studies on the size of antibodies, cofactor and nonspecific inhibitors of influenza virus using separation on Sephadex G-200. Science Tools 10, 1–4 (1963 b).

    Google Scholar 

  • Harboe, A., and R. Reenaas: The course of antibody development to influenza A2 strains. Acta path. microbiol. scand. 46, 266–272 (1959).

    PubMed  CAS  Google Scholar 

  • Harboe, A., and R. Reenaas, and M. Oppedal: Studies on Francis inhibitor of influenza virus hemagglutination in rabbit serum fractions obtained by electrophoresis on starch-grain. Acta path. microbiol. scand. 44, 92–105 (1958).

    PubMed  CAS  Google Scholar 

  • Hollós, I.: The effect of modified Francis-inhibitors on reproduction of influenza virus. Acta microbiol. Acad. Sci. hung. 10, 82–83 (1963).

    Google Scholar 

  • Horváth, S.: Comparison of the experimental results obtained in the course of inactivation of non-specific inhibitors in serum by means of the haemagglutination and virus neutralization tests. Arch. ges. Virusforsch. 11, 295–303 (1961).

    PubMed  Google Scholar 

  • Isaacs, A., and A. Bozzo: The use of V. cholerae filtrates in the destruction of non-specific inhibitor in ferret sera. Brit. J. exp. Path. 32, 325–335 (1951).

    PubMed  CAS  Google Scholar 

  • Isachenko, V. A., G. A. Smirnova, and A. S. Gorbunova: Isolation of an inhibitor-sensitive variant from an inhibitor-resistant influenza A2 culture by gel-filtration with Sephadex. Vop. Virus. 10, 97–98 (1965) [in Russian].

    PubMed  CAS  Google Scholar 

  • James, S. M., and P. Fiset: Serum inhibitors of Asian strains of influenza virus. Nature (Lond.) 184, Suppl. 21, 1656–1657 (1959).

    Google Scholar 

  • Jandásek, L.: Study of the interaction between the “transition strains” of influenza virus A2 and the inhibitor contained in the sera of normal guinea pigs. J. Hyg. Epidem. (Praha) 8, 44–48 (1964).

    Google Scholar 

  • Jandásek, L.: Inhibitoren des Influenzavirus. Arch. exp. Vet. Med. 21, 313–318 (1967).

    Google Scholar 

  • Jensen, K. E.: “Memorandum”. Communicable Disease Center, Montgomery, Alabama, 1958.

    Google Scholar 

  • Jandásek, L., and A. Montgomery: New set of type A influenza viruses. J. Amer. med. Ass. 164, 2025–2029 (1957).

    Google Scholar 

  • Jordan, W. S., and R. O. Ozeasohn: The use of RDE to improve the sensitivity of hemagglutination-inhibition test for the serologic diagnosis of influenza. J. Immunol. 72, 229–235 (1954).

    PubMed  Google Scholar 

  • Karzon, D. T.: Non-specific viral inactivating substance (VIS) in human and mammalian sera. J. Immunol. 76, 454–463 (1956).

    PubMed  CAS  Google Scholar 

  • Karzon, D. T., and R. H. Bussell: Studies of the nonspecific inactivation of Newcastle disease virus by mammalian sera. Ann. N.Y. Acad. Sci. 83, 539–550 (1960).

    PubMed  CAS  Google Scholar 

  • Kathan, R. H., C. A. Johnson, and R. J. Winzler: On the glycoprotein inhibitor of viral hemagglutination from human erythrocytes. Acta Soc. Med. upsalien. 64, 290 (1959).

    CAS  Google Scholar 

  • Kathan, R. H., and R. J. Winzler: Structure studies on the myxovirus hemagglutination inhibitor of human erythrocytes. J. biol. Chem. 238, 21–25 (1963).

    CAS  Google Scholar 

  • Kathan, R. H., and R. J. Winzler, and C. A. Johnson: Preparation of an inhibitor of viral hemagglutination from human erythrocytes. J. exp. Med. 113, 37–45 (1961).

    PubMed  CAS  Google Scholar 

  • Klein, M., and A. Deforest: A serum inhibitor in animal and human sera of bovine enteroviruses. II. In vivo activity and role in “natural” resistance to infection. J. Immunol. 92, 822–826 (1964b).

    PubMed  CAS  Google Scholar 

  • Klein, M., G. Evans, A. Deforest, and B. Kleger: A serum inhibitor in animal and human sera of bovine enteroviruses. I. Properties and in vitro activity. J. Immunol. 95, 816–821 (1964a).

    Google Scholar 

  • Klein, M., G. Evans, and Y. Zellat: Properties of non-antibody inhibitor in the sera of man and other animals. Fed. Proc. 21, 461 (1962).

    Google Scholar 

  • Konno, J.: Beta-inhibitor, its biological and physico-chemical properties with particular emphasis on the differences from alfa-inhibitor, immune serum and properdin. Tohoku J. exp. Med. 67, 391–405 (1958).

    PubMed  CAS  Google Scholar 

  • Kosyakov, P. N., M. S. Berdinskikh, and Z. I. Rovnova: Ability of viruses to overcome the action of inhibitors and antibodies. Vop. Virus. 7, 28–35 (1962b) [in Russian].

    Google Scholar 

  • Kosyakov, P. N., N. M. Gruzdeva, and M. S. Berdinskikh: The problem of the therapeutic effect of specific antibodies and inhibitors in influenza infection. Vop. Virus. 8, 301–307 (1963) [in Russian].

    Google Scholar 

  • Kosyakov, P. N., and Z. I. Rovnova: Virus-cell system exposed to specific antibody and inhibitors. VIIIth Int. Congr. for Microbiology, Abstracts, Montreal, Quebec, Canada, No. E 32 B. 12. p. 109 (1962a).

    Google Scholar 

  • Krasovskaya, I. A.: Changes in some properties of influenza A2 virus after treatment with sodium periodate. Vop. Virus. 9, 434–437 (1964) [in Russian].

    Google Scholar 

  • Krikszens, A. E.: Some chemical and physical characteristics of purified beta-inhibitor from bovine serum. Proc. Soc. exp. Biol. (N.Y.) 126, 176–181 (1967).

    CAS  Google Scholar 

  • Križanová, O., and J. Leško: Separation of gamma-inhibitor on carboxymethyl cellulose. Acta virol. 7, 179–182 (1964).

    Google Scholar 

  • Križanová, O., V. Rathová, D. Kočišková, and J. Szántó: The purification and some properties of the beta-inhibitor from bovine serum. Bratisl. lek. Listy 43, 22–29 (1963) [in Slovak].

    Google Scholar 

  • Križanová, O., and F. Sokol: Purification of bovine serum beta inhibitor by chromatographic methods and its reaction with Al influenza virus. Acta virol. 10, 35–42 (1966).

    PubMed  Google Scholar 

  • Križanová-Laučíková, O., J. Szántó, and P. Albrecht: Localization of virus hemagglutination inhibitor in the chorioallantoic membrane. Virology 15, 501–503 (1961a).

    PubMed  Google Scholar 

  • Križanová-Laučíková, O., J. Szántó, and D. Kočišková: Purification and some properties of the thermostable inhibitor against avid A2 influenza virus from horse serum. Acta virol. 5, 4–11 (1961b).

    PubMed  Google Scholar 

  • Križanová-Laučíková, O., J. Szántó, and D. Kočišková, G. Ruttkay-Nedecký, and F. Sokol: Differences in the properties of two inhibitors avid A2 influenza virus strains from horse serum. Acta virol. 5, 12–18 (1961c).

    PubMed  Google Scholar 

  • Laurell, A. B.: Inhibitor capacity of some purified human serum proteins on haemagglutination by influenza virus. Acta path. microbiol. scand. 49, 213–222 (1960).

    PubMed  CAS  Google Scholar 

  • Levy, A. H., P. S. Norman, and R. R. Wagner: Electrophoresis of serum inhibitors of influenza viruses. Fed. Proc. 18, 580 (1959).

    Google Scholar 

  • Link, F., D. Blaškovič, and J. Raus: On the therapeutic effect of gamma inhibitor in mice infected with an inhibitor-sensitive unadapted A2 influenza virus. Acta virol. 9, 553 (1965).

    PubMed  CAS  Google Scholar 

  • Link, F., J. Szántó, and O. Križanová: A quantitative assay of the in vivo protective effect of gamma inhibitor against inhibitor sensitive A2 influenza virus strain. Acta virol. 8, 71–75 (1964).

    PubMed  CAS  Google Scholar 

  • Lippelt, H., u. W. Wirth: Unspezifische Hemmfaktoren im Meerschwein-Normalserum gegenüber Influenza-Viren. Arch. ges. Virusforsch. 9, 497–509 (1959).

    PubMed  CAS  Google Scholar 

  • Lobodziňska, M., and O. Križanová: The relationship between hemagglutination and adsorption of influenza viruses on red blood cells of different animal species and their total sialic acid content. Arch. Immunol. Ter. dośw. 13, 631–638 (1965).

    Google Scholar 

  • Lobodziňska, M., and O. Križanová: Purification and properties of an influenza virus inhibitor isolated from mouse lungs. Acta virol. 10, 28–34 (1966).

    PubMed  Google Scholar 

  • Luzyanina, T. Ya., and R. Ya. Polyak: Localization on the termolabile virus-neutralizing factors in the protein fractions of rabbit and guinea pig sera. Yearbook Institute of Experimental Medicine of the Academy of Medical Sciences of the USSR, 1957, p. 330–332. Leningrad 1958 [in Russian].

    Google Scholar 

  • Luzyanina, T. Ya., and R. Ya. Polyak, and A. A. Smorodintsev: Virus-neutralizing activity of non-specific thermolabile normal serum inhibitors against the myxovirus, adenovirus and enterovirus groups. Yearbook Institute of Experimental Medicine of the Academy of Medical Sciences of the USSR, 1960, p. 422–427. Leningrad 1961 [in Russian].

    Google Scholar 

  • Luzyanina, T. Ya., A. L. Salminen, and A.A. Smorodintsev: Peculiarities of the interaction of thermostable inhibitors from normal sera with type A2 influenza viruses of the 1957 pandemic Acta virol. 4, 137–145 (1960).

    Google Scholar 

  • Luzyanina, T. Ya., and A. A. Smorodintsev: Neutralization of mumps virus in chick embryo cell cultures. Acta virol. 9, 160–164 (1965).

    PubMed  CAS  Google Scholar 

  • McCrea, J. F.: Nonspecific serum inhibition of influenza haemagglutination. Aust. J. exp. Biol. med. Sci. 24, 283–291 (1946).

    PubMed  CAS  Google Scholar 

  • McCrea, J. F.: Mucins and mucoids in relation to influenza virus action. II. Isolation and characterization of the serum mucoid inhibitor of heated influenza virus. Aust. J. exp. Biol. med. Sci. 26, 355 (1948).

    PubMed  CAS  Google Scholar 

  • Medill-Brown, M., and B. A. Briody: Mutation and selection pressure during adaptation of influenza virus to mice. Virology 1, 301–312 (1955).

    PubMed  CAS  Google Scholar 

  • Meyer, H. M., Jr., M. R. Hilleman, M. L. Miesse, I. P. Cramford, and A. S. Bankhead: New antigenic variant in Far East influenza epidemic 1957. Proc. Soc. exp. Biol. (N.Y.) 95, 609–6l6 (1957).

    Google Scholar 

  • Morawiecki, A., and E. Lisowska: Polymerized orosomucoid an inhibitor of influenza virus hemagglutination. Biochem. biophys. Res. Commun. 18, 606–610 (1965).

    PubMed  CAS  Google Scholar 

  • More virus inhibitors. (Leading articles.) Lancet 1961 I, 755–756.

    Google Scholar 

  • Mulder, J., de Novijer, and L. M. Blans: The influence of treating ferret influenza antisera with enzymes of crude filtrate of Vibrio cholerae on the titre of the antibodies. Antonie van Leeuwenhoek 18, 128 (1952).

    PubMed  CAS  Google Scholar 

  • Nagase, M., and Y. Kabata: Possible destruction of antibody by treating human serum with KIO4. Studies on several inhibitors against influenza viruses. Virus (Jap.) 11, 65 (1961) [in Japan with English summary].

    Google Scholar 

  • Niculescu, I.: Inhibitors of influenza viruses. Microbiologia, parasitologia, epidemiologia (Rumun.) 10, 103–110 (1965) [in Rumunian].

    CAS  Google Scholar 

  • Odin, L.: Sialic acid in human serum protein and meconium. Acta chem. scand. 9, 862 (1955).

    CAS  Google Scholar 

  • Orsi, N.: Inhibitori naturali dell’infettività virale. Riv. Ist. sieroter. ital. 41, 77–91 (1966) [in Italian].

    PubMed  CAS  Google Scholar 

  • Orsi, N., R. Calio, A. Stasio, and L. Sinibaldi: On the use of influenza virus strains sensitive to non-specific inhibitors in the hemagglutination-inhibition reaction. Riv. Ist. sieroter. ital. 42, 3–15 (1967).

    PubMed  CAS  Google Scholar 

  • Petrov, K. Yu.: Effect on influenza virus of unspecific virus neutralizing substances in animal sera. Vop. Virus. 5, 167–172 (1960) [in Russian].

    PubMed  Google Scholar 

  • Pichuskov, A. V.: Inhibitors of hemagglutination by parainfluenza virus types 1, 2, 3. Vop. Virus. 10, 74–78 (1965) [in Russian].

    Google Scholar 

  • Polyak, R. Ya., T. Ya. Luzyanina, and A. A. Smorodintsev: Biochemical investigation of influenza virus neutralizing protein fractions of sera from different animals. Acta virol. 3, 61–70 (1959).

    PubMed  Google Scholar 

  • Polyak, R. Ya., and A.A. Smorodintsev: Electrophoretic investigations of thermostable inhibitors of type A2 influenza virus in normal animal sera. Acta virol. 5, 1–3 (1961).

    Google Scholar 

  • Rathová, V.: The possible role of inhibitor in non-specific defence of the organism. Zprávy z epidemiol. mikrobiol. (Praha) 5, 46–52 (1963) [in Slovak].

    Google Scholar 

  • Rathová, V.: (1965): Unpublished results.

    Google Scholar 

  • Rathová, V., L. Borecký, and D. Kočišková: An attempt to influence in vivo the serum levels of myxovirus inhibitors. III. The effect of the administration of some vitamins on inhibitors and some other serum factors in guinea pigs and mice. Bratisl. lek. Listy 43, 31–40 (1963) [in Slovak].

    Google Scholar 

  • Rathová, V., and D. Kočišková: Antibody response after different modes of administration of the influenza virus group A2 in some laboratory animals and the influence of different methods of removing non-specific inhibitors on the titre of specific antibodies in their sera. Čs. Epidem. 10, 170–175 (1961) [in Slovak].

    Google Scholar 

  • Rathová, V., and D. Kočišková, J. Szántó, O. Laučíková, and L. Hána: Some properties of the virus-neutralizing factor of normal animal sera. Vop. Virus 4, 717–723 (1959) [in Russian].

    PubMed  Google Scholar 

  • Reimold, G.: Über die Wechselwirkung von Seruminhibitoren, Hühnererythrocyten und Influenzaviren. Z. Immun.-Forsch. 118, 121–134 (1959).

    CAS  Google Scholar 

  • Rovnova, Z. I., and P. N. Kosyakov: Inhibitors and antibodies in the course of immunization of animals with viral preparations. Acta virol. 11, 69–77 (1967).

    CAS  Google Scholar 

  • Rykowska, R., and L. Sawicki: The gamma-inhibitor of normal horse serum. II. The protective properties of the serum and its fractions against infection of mice and tissue cultures with the Singapore strains of influenza virus. Med. dosw. Mikrobiol. 15, 47–54 (1963) [in Polish].

    PubMed  CAS  Google Scholar 

  • Sampaio, A. A. C.: Inhibitors of influenza virus haemagglutination in normal animal sera. Bull. Wld Hlth Org. 6, 467–472 (1952).

    CAS  Google Scholar 

  • Sampaio, A. A. C., and A. Isaacs: The action of trypsin on normal serum inhibitors of influenza virus agglutination. Brit. J. exp. Path. 34, 152–158 (1953).

    Google Scholar 

  • Sawicki, L., and R. Rykowska: The guinea pig and white rat serum inhibitors as a possible factor of natural resistance of these animals to infection with certain strains of influenza virus. Med. došw. Mikrobiol. 15, 55–64 (1963) [in Polish].

    PubMed  CAS  Google Scholar 

  • Schmidt, B., K. Grossgebauer u. D. Hartmann: Über die Enzymaktivität äthergespaltener Influenzaviren und ihren Einfluß auf unspezifische Seruminhibitoren. Z. Immun.-Forsch. 120, 238–248 (1960).

    CAS  Google Scholar 

  • Shimizu, N., and N. Ishida: The characteristics of both hemagglutinin inhibitors and growth inhibitory substances of influenza viruses found in animal specimens. Tohoku J. exp. Med. 67, 390 (1958).

    PubMed  CAS  Google Scholar 

  • Shimojo, H., A. Sugiura, J. Akao, and Ch. Enomoto: Studies of a non-specific hemagglutination inhibitor of influenza A (Asian) 57 virus. Bull. Inst. Publ. Health 7, 219–224 (1958).

    Google Scholar 

  • Shiratori, T., M. Nagase, H. Kudo, T. Kikawa, and Y. Kabata: Characterization of non-specific hemagglutinin inhibitors detectable in the sera of experimental animals. Virus (Jap.) 11, 162–163 (1961).

    Google Scholar 

  • Simkin, J. L., E. R. Skinner, and H. S. Seshadri: Studies on an acidic glyco-protein-containing fraction isolated from guinea-pig serum. Biochem. J. 90, 316–330 (1964).

    PubMed  CAS  Google Scholar 

  • Smith, W., and J. C. N. Westwood: Influenza virus haemagglutination. The mechanism of the Francis phenomenon. Brit. J. exp. Path. 31, 725–738 (1950).

    PubMed  CAS  Google Scholar 

  • Smith, W., and J. C. N. Westwood, and G. Belyavin: Influenza: A study of four virus strains isolated in 1951. Lancet 1951 II, 1189.

    Google Scholar 

  • Smith, W., and M. A. Westwood: Factors involved in influenza haemagglutination reactions. Brit. J. exp. Path. 30, 48–61 (1949).

    PubMed  CAS  Google Scholar 

  • Smorodintsev, A. A.: Factors of natural resistance and specific immunity to viruses. Virology 3, 299–321 (1957).

    PubMed  CAS  Google Scholar 

  • Smorodintsev, A. A., and T. Ya. Luzyanina: Interaction of the thermolabile fractions of normal sera from various animals and the virulent and avirulent strains of the influenza virus. Yearbook Inst. of exp. Med. of the Acad. Med. Sci. USSR, 1957, p. 326–330, Leningrad 1958 [in Russian].

    Google Scholar 

  • Smorodintsev, A. A., and O. I. Šiškina: The effect of normal laboratory animal sera on influenza virus. Zh. Mikrobiol. (Mosk.) 22, 16–19 (1951) [in Russian].

    Google Scholar 

  • Springer, G. F.: Human MN glycoproteins: Dependence of blood-group and anti-influenza virus activities on their molecular size. Biochem. biophys. Res. Commun. 28, 510–513 (1967).

    PubMed  CAS  Google Scholar 

  • Stone, J. D.: Inhibition of influenza virus hemagglutination by mucoids. II. Differential behaviour of mucoid inhibitors with indicator viruses. Aust. J. exp. Biol. med. Sci. 27, 557 (1949).

    Google Scholar 

  • Stone, J. D.: Adsorptive and enzymatic behaviour of influenza virus during the O-D change. Brit. J. exp. Path. 32, 367–376 (1951).

    PubMed  CAS  Google Scholar 

  • Stulberg, C. C., R. Schapira, A. R. Robinson, D. H. Basinski, and H. A. Freund: Inhibition of influenza virus hemagglutination by purified plasma mucoproteins. Proc. Soc. exp. Biol. (N.Y.) 76, 704–706 (1961).

    Google Scholar 

  • Styk, B.: Non-specific inhibitors in normal rat serum for the influenza C type virus. Fol. biol. (Praha) 1, 207–213 (1955).

    Google Scholar 

  • Styk, B.: Inhibitors of the influenza virus in human sera after passaging in volunteers. Acta virol. 1, 238–239 (1957).

    PubMed  CAS  Google Scholar 

  • Styk, B.: Sensibilization by means of potassium periodate of inhibitor-resistant A2 influenza virus strains to non-specific serum inhibitors. Nature (Lond.) 193, 954–955 (1962a).

    CAS  Google Scholar 

  • Styk, B.: Effect of some inhibitor-destroying substances on the non-specific inhibitor of C influenza virus present in normal rat serum. Acta virol. 7, 88–89 (1963).

    CAS  Google Scholar 

  • Styk, B., L. Hána, F. Franěk, F. Sokol, and J. Menšík: Investigations on cofactor and influenza antibodies by density gradient zonal centrifugation. Acta virol. 6, 478 (1962 b).

    PubMed  CAS  Google Scholar 

  • Sugiura, A., H. Shimojo, and C. Enomoto: Studies of the non-specific hemagglutination inhibitor against influenza A2 virus (gamma-inhibitor). II. Physicochemical properties of the gamma-inhibitor. Jap. J. exp. Med. 31, 159–168 (1961 a).

    PubMed  CAS  Google Scholar 

  • Sugiura, A., H. Shimojo, and C. Enomoto: Studies of the non-specific hemagglutination inhibitor against influenza A2 virus. III. Destruction of gamma-inhibitor by virus enzyme. Jap. J. exp. Med. 31, 169–177 (1961 b).

    PubMed  CAS  Google Scholar 

  • Szántó, J., O. Križanová, and F. Link: Interaction of gamma-inhibitor with A2 influenza virus. Acta virol. 6, 524–530 (1962).

    Google Scholar 

  • Takátsy, G., and K. Barb: On the normal serum inhibitors for the avid Asian strains of influenza virus. Acta virol. 3, (Suppl.) 71–79 (1959).

    PubMed  Google Scholar 

  • Topciu, V., P. Diosi, E. Moldovan, O. Nevinglovschi, and G. Bran: Serological survey concerning the presence of influenza hemagglutination inhibitors in normal dog sera. Acta virol. 11, 55–57 (1967).

    PubMed  CAS  Google Scholar 

  • Topciu, V., E. Moldovan, O. Nevinglovschi, N. Rosiu, and P. Diosi: Serological investigations on influenza inhibitors in domestic and wild animals. Rev. Roum. Infra-microbiol. 3, 271–276 (1966).

    Google Scholar 

  • Toussaint, A. J., and L. H. Muschel: Neutralization of bacteriophage by normal serum. Nature (Lond.) 183, 1825–1827 (1959).

    CAS  Google Scholar 

  • Tyrrell, D. A. J.: Separation of inhibitors of hemagglutination and specific antibodies for influenza viruses by starch zone electrophoresis. J. Immunol. 72, 494–502 (1954).

    PubMed  CAS  Google Scholar 

  • Voláková, N., and L. Jandásek: A thermostable inhibitor of newly isolated influenza strains in guinea pig serum. Acta virol. 3, 109–112 (1959).

    PubMed  Google Scholar 

  • Voluyskaya, E. N., V. I. Tovarnicky, and A. M. Byelikova: The effect of the properdin system on the influenza virus. J. Hyg. Epidem. (Praha) 2, 404–407 (1958).

    CAS  Google Scholar 

  • Wagner, R. R.: A pantropic strain of influenza virus: Generalized infection and viremia in the intact mouse. Virology 1, 497–515 (1955).

    PubMed  CAS  Google Scholar 

  • Wenner, H. A., A. Monley, and M. K. Jensen: A study of infections caused by mumps and NDV viruses. II. Some properties of specific and nonspecific serum hemagglutination inhibitor components. J. Immunol. 68, 357–368 (1952).

    PubMed  CAS  Google Scholar 

  • Werner, G. H., R. Sharma, and L. Gogolski: Hemagglutinin inhibition with ether-treated antigen as a more sensitive method to measure the immunological response to an Asian influenza virus vaccine. Arch. ges. Virusforsch. 10, 7–18 (1960).

    PubMed  CAS  Google Scholar 

  • Whitehead, P. H.: Viral inhibition by polymerized orosomucoid. Biochem. J. 95, 8P (1965).

    CAS  Google Scholar 

  • Whitehead, P. H., T. H. Flewet, J. R. Foster, and H. G. Sammons: Inhibition of influenza virus haemagglutination by polymerized orosomucoid. Nature (Lond.) 208, No 5013, 915–916 (1965).

    CAS  Google Scholar 

  • Yakhno, M. A.: Influence of inhibitor-destructive treatment on influenza antibody. Vop. Virus. 6, 334–335 (1961) [in Russian].

    Google Scholar 

  • Zakstelskaya, L. Y., and M. A. Yakhno: The sensitivity of different strains of A2 influenza virus to the action of inhibitors occurring in animal sera. Vop. med. Virus. (Mosk.) 5, 71–73 (1958) [in Russian].

    Google Scholar 

  • Zhdanov, V. M., V. P. Gamburg, and G. J. Svet-Moldavsky: Antigenicity of the inhibitor of influenza virus strain A (Asie) 57. J. Immunol. 82, 9–12 (1959).

    PubMed  CAS  Google Scholar 

  • Zhdanov, V. M., L. J. Zakstelskaya, V. E. Jefimova, M. A. Yakhno, and S. L. Khait: Antigenic peculiarities of 1957 influenza viruses and serologic indexes of immunity among the population. J. Amer. med. Ass. 167, 1469–1474 (1958).

    CAS  Google Scholar 

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Križanová, O., Rathová, V. (1969). Serum Inhibitors of Myxoviruses. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46160-6_6

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