The Influence of Enzymes on Neurohypophysial Hormones and Similar Peptides

  • Hans Tuppy
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 23)


Oxidizing, reducing and, particularly, proteolytic enzymes have proved capable of affecting oxytocin, vasopressin and related peptides. Their action has been studied for several reasons. Neurohypophysial hormones can be distinguished from each other and from unrelated biologically active compounds by their different susceptibility to enzymatic inactivation. Specifically acting enzymes are valuable tools in studies of hormone structure and structure-activity relationship. The occurrence, distribution and biological significance of enzymes, which may be involved in the metabolism of the neurohypophysial hormones under normal and pathological conditions, have of course been of particular interest. Enzymes may possibly play a physiological role in the release of the hormones from the sites of their synthesis or storage. Enzymes may influence the hormone levels in the circulation. Certainly, enzymes are involved in the breakdown of the hormones in various tissues. The insight into the role and mode of action of the enzymes involved in hormone metabolism has stimulated the synthesis of hormone analogues resistant to enzymatic attack and of hormone precursors which will release active hormones in enzyme-catalyzed reactions. Moreover, compounds have been studied which will either inhibit or activate the hormone-degrading enzymes and thus, it is hoped, enhance or depress, respectively, the action of the hormones themselves.


Leucine Aminopeptidase Similar Peptide Pregnancy Serum Neurohypophysial Hormone Placental Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



adrenocorticotropic hormone


cystine aminopeptidase


ethylene diamine tetraacetate




oxide form of glutathione


leucine aminopeptidase


β-melanocyte-stimulating hormone


nicotinamide adenine dinucleotide phosphate


reduced form of nicotinamide adenine dinucleotide phosphate




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© Springer-Verlag Berlin Heidelberg 1968

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  • Hans Tuppy

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