Chemistry of the Neurohypophysial Hormones

  • R. A. Boissonnas
  • St. Guttmann
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 23)


Seven chemically related hormones have been detected up to now in the neurohypophyses of mammals, birds, amphibians and fish: oxytocin, vasopressin, lysine-vasopressin, vasotocin, mesotocin, isotocin and glumitocin. As can be seen from their chemical structure (Fig. 1), they all consist of a peptide chain of nine amino acid residues and are therefore, strictly speaking, nonapeptides. The two half cystine residues occupying the 1st and the 6th positions of the chain are linked together by their sulphur atoms, thus forming a ring of 20 atoms. As these two half cystine residues constitute together one cystine residue, some authors formerly designated these hormones as octapeptides, but this nomenclature is now considered illogical, for it is impossible to apply it in the case of more complicated peptides like insulin, which have nevertheless the same 20 atom ring.


Liquid Ammonia Disulphide Bridge Performic Acid Neurohypophysial Hormone Tosyl Group 
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  • R. A. Boissonnas
  • St. Guttmann

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