Abstract
Bacitracin is produced by strains of Bacillus licheniformis. The commercial product contains a main component, bacitracin A (Fig. 1), and at least nine additional closely related polypeptides (Regna, 1959)- In neutral or slightly alkaline solution, bacitracin A is slowly transformed into bacitracin F (Fig. 2) (Regna, 1959) which has very little antibacterial activity (Hickey, 1964).
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References
Abraham, E. P., and G. G. F. Newton: Structure and function of some sulfur containing peptides. In: CIBA foundation symposium on amino acids and peptides with antimetabolic activity, p. 205. London: J. & A. Churchill Ltd. 1958.
Adler, R. H., and J. E. Snoke: Requirement of divalent metal ions for bacitracin activity. J. Bacteriol. 83, 1315 (1962).
Albert, A.: Metal-binding agents in chemotherapy: the activation of metals by chelation. In: The strategy of chemotherapy, p. 112. Cambridge: Cambridge University Press 1958.
Anderson, J. S., M. Matsuhashi, M. A. Haskin, and J. L. Strominger: Lipid-phosphoacetylmuramylpentapeptide and lipid-phosphodisaccharide-pentapeptide: presumed membrane transport intermediates in cell wall synthesis. Proc. Natl. Acad. Sci. U.S. 53, 881 (1965).
Anker, H. S., B.A. Johnson, J. Goldberg, and F. L. Meleney: Bacitracin: methods of production, concentration, and partial purification, with a summary of the chemical properties of crude bacitracin. J. Bacteriol. 55, 249 (1948).
Bare, L. N., R. F. Wiseman, and O. J. Abbott: Levels of antibiotics in the intestinal tract of chicks fed bacitracin and penicillin. Poultry Sci. 44, 489 (1965).
Brock, T. D.: Effect of antibiotics and inhibitors on M protein synthesis. J. Bacteriol. 85, 527 (1963).
Chornock, F. W.: Zinc bacitracin feed supplement. U.S.Patent 2, 809, 892 (1957).
Creaser, E. H.: The induced (adaptive) biosynthesis of β-galactosidase in Staphylococcus aureus. J. Gen. Microbiol. 12, 288 (1955).
Foye, W. A.: Role of metal-binding in the biological activities of drugs. J. Pharmaceut. Sci. 50, 93 (1961).
Gale, E. F., and J. P. Folkes: The assimilation of amino acids by bacteria. 15. Actions of antibiotics on nucleic acid and protein synthesis in Staphylococcus aureus. Biochem. J. 53, 493 (1953).
Gale, E. F., and J. P. Folkes: The assimilation of amino acids by bacteria. 21. The effect of nucleic acids on the development of certain enzymatic activities in disrupted staphylococcal cells. Biochem. J. 59, 675 (1955).
Garbutt, J. T., A. L. Morehouse, and A. M. Hanson: Metal binding properties of bacitracin. J. Agr. Food Chem. 9, 285 (1961).
Gezon, H. M., D. M. Fasan, and G. R. Collins: Antibiotic studies on beta hemolytic streptococci. VII. Acquired in vitro resistance to bacitracin. Proc. Soc. Exptl. Biol. Med. 74, 505 (1950).
Gross, H. M.: Zinc bacitracin in pharmaceutical preparations. Drug & Cosmetic Ind. 75, 612 (1954).
Hancock, R., and P. C. Fitz-James: Some differences in the action of penicillin, bacitracin, and vancomycin on Bacillus megaterium. J. Bacteriol. 87, 1044 (1964).
Helms, V., and E.D. Weinberg: Mechanism of antibacterial action of N1,N5-di (3, 4-dichlorobenzyl)-biguanide. In: Antimicrobial Agents and Chemotherapy 1962, p. 241. Ann Arbor (Mich.): Amer. Soc. Microbiol. 1963
Hickey, R. J.: Bacitracin, its manufacture and uses. Progr. Ind. Microbiol. 5, 95 (1964).
Hinton, N. A., and J. H. Orr: The effect of antibiotics on the toxin production of Staphylococcus aureus. Antibiotics & Chemotherapy 10, 758 (1960).
Hodge, E. B., and G. J. Lafferty: Zinc bacitracin-containing troche. U.S. Patent 2, 803, 584 (1957).
Jawetz, E.: Polymyxin, Colistin, and bacitracin. Pediat. Clin. North Am. 8, 1057 (1961).
Krawitt, E. L., and J. R. Ward: L phase variants related to antibiotic inhibition of cell wall biosynthesis. Proc. Soc. Exptl. Biol. Med. 114, 629 (1963).
Lowbury, E. J. L.: Clinical problems of drug-resistant pathogens. Brit. Med. Bull. 16, 73 (1960).
Mandelstam, J., and H. J. Rogers: The incorporation of amino acids into the cellwall mucopeptide of staphylococci and the effect of antibiotics on the process. Biochem. J. 72, 654 (1959).
Maxted, W. R.: The use of bacitracin for identifying group A haemolytic streptococci. J. Clin. Pathol. 6, 224 (1953).
Molander, C. W., B. M. Kagan, H. J. Weinberger, E. M. Heimlich, and R. J. Busser: Induction by antibiotics and comparative sensitivity of L-phase variants of Staphylococcus aureus. J. Bacteriol. 88, 591 (1964).
Park, J. T.: Inhibition of synthesis of bacterial mucopeptide or protein by certain antibiotics and its possible significance for microbiology and medicine. In: Antimicrobial Agents Ann. 1960, p. 338. New York: Plenum Press 1961.
Petran, E. I.: Comparison of the fluorescent antibody and the bacitracin disk methods for identification of group A streptococci. Amer. J. Clin. Pathol. 41, 224 (1961).
Regna, P. P.: The chemistry of antibiotics. In: Antibiotics; their chemistry and nonmedical uses, p. 58. New York: D. van Nostrand Co., Inc. 1959
Rotta, J., W. W. Karakawa, and R. M. Krause: Isolation of L forms from group A streptococci exposed to bacitracin. J. Bacteriol. 89, 1581 (1965).
Schroeder, H.A., and J. J. Balassa: Abnormal trace metals in man: cadmium. J. Chronic Diseases 14, 236 (1961).
Sharp, V. E., A. Arriagada, G. G. F. Newton, and E.P. Abraham: Ayfivin: extraction, purification, and chemical properties. Brit. J. Exptl. Pathol. 30, 444 (1949).
Shockman, G. D., and J.O. Lampen: Inhibition by antibiotics of the growth of bacterial and yeast protoplasts. J. Bacteriol. 84, 508 (1962).
Smith, J. L., and E. D. Weinberg: Mechanisms of antibacterial action of bacitracin. J. Gen. Microbiol. 28, 559 (1962).
Snoke, J. E., and N. Cornell: Protoplast lysis and inhibition of growth of Bacillus licheniformis by bacitracin. J. Bacteriol. 89, 415 (1965).
Stone, J. L.: Induced resistance to bacitracin in cultures of Staphylococcus aureus. J. Infectious Diseases 85, 91 (1949).
Szybalski, W., and V. Bryson: Genetic studies on microbial cross resistance to toxic agents. 1. Cross resistance of Escherichia coli to fifteen antibiotics. I. Bacteriol. 64, 489 (1952).
Tipton, I. H., and M. J. Cook: Trace elements in human tissue. Part II. Adult subjects from the United States. Health Physics 9, 103 (1963).
Tipton, I. H., H. A. Schroeder, H. M. Perry JR., and M. J. Cook: Trace elements in human tissue. Part III. Subjects from Africa, the Near and Far East, and Europe. Health Physics 11, 403 (1965).
Vohra, P., and F. H. Kratzer: Influence of various chelating agents on the availability of zinc. J. Nutrition 82, 249 (1964).
Ward, J. R., S. Madoff, and L. Dienes: In vitro sensitivity of some bacteria, their L forms and pleuropneumonia-like organisms to antibiotics. Proc. Soc. Exptl. Biol. Med. 97, 132 (1958).
Weinberg, E. D.: The mutual effects of antimicrobial compounds and metallic cations. Bacteriol. Rev. 21, 46 (1957).
Weinberg, E. D.: Enhancement of bacitracin by the metallic ions of group IIB. In: Antibiotics Annual 1958/59, 924. New York (N.Y.): Medical Encyclopedia, Inc. 1959.
Weinberg, E. D.: Known and suspected roles of metal coordination in actions of antimicrobial drugs. Federation Proc. 20 (Suppl. 10), 132 (1961).
Weinberg, E. D.: Antibacterial action of polyamines in presence of trace metals: enhancement by cadmium. In: Antimicrobial Agents and Chemotherapy 1963, 573. Ann Arbor (Mich.): Amer. Soc. Microbiol. 1964.
Weinberg, E. D.: Microbiological method for estimation of stability constants of bacitracin complexes of zinc, cadmium, and manganese. In: Antimicrobial Agents and Chemotherapy 1964, 120. Ann Arbor (Mich.): Amer. Soc. Microbiol. 1965
Williams, R. E. O.: L forms of Staphylococcus aureus. J. Gen. Microbiol. 33, 325 (1963).
Wise, E. M., and J. T. Park: Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in cell wall mucopeptide synthesis. Proc. Natl. Acad. Sci. U.S. 54, 75 (1965).
Ziffer, J., and T. J. Cairney: Bacitracin composition as feed additive. U.S. Patent 3, 025, 216 (1962).
Zinn, E., and F. W. Chornock: Production of bacitracin. U.S.Patent 2, 834, 711 (1958).
Zorn, R. A.: Stabilization of bacitracin. U.S. Patent 2, 903, 357 (1959).
Zorn, R. A.: Bacitracin product. U.S. Patent 3, 021, 217 (1962).
Zorn, R. A., R. C. Malzahn, and A. M. Hanson: Bacitracin. U.S. Patent 2, 985, 534 (1961).
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Weinberg, E.D. (1967). Bacitracin. In: Gottlieb, D., Shaw, P.D. (eds) Mechanism of Action. Antibiotics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46051-7_5
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DOI: https://doi.org/10.1007/978-3-642-46051-7_5
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