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Sideromycins

  • Chapter
Mechanism of Action

Part of the book series: Antibiotics ((ANTIBIOTICS,volume 1))

Abstract

In recent years, substances containing iron and showing a broad absorption band, with an absorption maximum between 420 and 440 mμ, have been isolated from cultures of various microorganisms (Bickel et al., 1960a; Prelog, 1963; Keller-Schierlein et al., 1964). Within this group of naturally occurring substances can be found some which display antibiotic properties, whereas others antagonise this antibiotic activity and actually promote the growth of certain micro-organisms. Chemical studies have revealed that all these substances are iron (III)-trihydroxamate complexes. For this reason, Bickel et al. (1960a) designated them collectively as “siderochromes”. Subsequently, Zähner et al. (1962) subdivided them on the basis of their biological properties into the following categories:

  1. a)

    Sideromycins; i.e. siderochromes displaying antibiotic activity.

  2. b)

    Sideramines; i.e. siderochromes which competitively antagonise the antibiotic effect of the sideromycins and which also exert a growth-promoting action on certain micro-organisms.

  3. c)

    Siderochromes whose biological properties are as yet unknown.

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Authors
  1. J. Nüesch
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  2. F. Knüsel
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Editors and Affiliations

  1. University of Illinois, Urbana, Illinois, USA

    David Gottlieb (Professor of Plant Pathology) & Paul D. Shaw (Associate Professor of Biochemistry) (Professor of Plant Pathology) &  (Associate Professor of Biochemistry)

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Nüesch, J., Knüsel, F. (1967). Sideromycins. In: Gottlieb, D., Shaw, P.D. (eds) Mechanism of Action. Antibiotics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46051-7_41

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  • DOI: https://doi.org/10.1007/978-3-642-46051-7_41

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