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Mechanism of Action pp 481–493Cite as

Azaserine and 6-Diazo-5-Oxo-L-Norleucine (DON)

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Part of the book series: Antibiotics ((ANTIBIOTICS,volume 1))

Abstract

The discovery of azaserine in culture filtrates of Streptomyces fragilis (Anderson et al., 1956) was announced by Ehrlich et al. (1954); and its inhibitory activity against Crocker Mouse Sarcoma 180 was described (Stock et al., 1954). 6-Diazo-5-oxo-L-norleucine(DON), produced by an unidentified Streptomyces, was discovered shortly thereafter (Ehrlich et al., 1956; Clark, Reilly and Stock, 1956). Azaserine occupies a unique position in the historical development of antibiotics: it is the first antibiotic whose discovery was the direct result of a systematic search for tumor-inhibiting antibiotics. Although equivocal clinical utility has been demonstrated against various malignancies, both of these antibiotics have proved to be valuable research tools and significant biochemical advances have resulted from their discovery.

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  1. University of Illinois, Urbana, Illinois, USA

    David Gottlieb (Professor of Plant Pathology) & Paul D. Shaw (Associate Professor of Biochemistry) (Professor of Plant Pathology) &  (Associate Professor of Biochemistry)

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Pittillo, R.F., Hunt, D.E. (1967). Azaserine and 6-Diazo-5-Oxo-L-Norleucine (DON). In: Gottlieb, D., Shaw, P.D. (eds) Mechanism of Action. Antibiotics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46051-7_39

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  • DOI: https://doi.org/10.1007/978-3-642-46051-7_39

  • Publisher Name: Springer, Berlin, Heidelberg

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  • Online ISBN: 978-3-642-46051-7

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