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D-Cycloserine and O-Carbamyl-D-serine

  • Chapter
Mechanism of Action

Part of the book series: Antibiotics ((ANTIBIOTICS,volume 1))

Abstract

Alanine is a major component of the peptidoglycan (mucopeptide) and teichoic acid moieties of bacterial cell walls (Salton, 1964). Part of the alanine in the wall is present as the D-isomer (39–50% in Streptococcus faecalis (Ikawa and Snell, 1960; Toennies and Shockman, 1959) and 67% in Staphylococcus aureus (Strominger et al., 1959). Salton (1961) has proposed that the occurrence of D-amino acids in the wall renders the bacterium resistant to proteolytic enzymes. Thus, it may be argued that the introduction of D-amino acids, e.g. D-alanine and D-glutamic acid, into the bacterial wall is a protective mechanism that the bacterium possesses against its environment.

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  1. Francis C. Neuhaus
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  1. University of Illinois, Urbana, Illinois, USA

    David Gottlieb (Professor of Plant Pathology) & Paul D. Shaw (Associate Professor of Biochemistry) (Professor of Plant Pathology) &  (Associate Professor of Biochemistry)

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Neuhaus, F.C. (1967). D-Cycloserine and O-Carbamyl-D-serine. In: Gottlieb, D., Shaw, P.D. (eds) Mechanism of Action. Antibiotics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46051-7_3

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