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Sparsomycin

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Mechanism of Action

Part of the book series: Antibiotics ((ANTIBIOTICS,volume 1))

Abstract

Sparsomycin is one of the antibiotics produced by Streptomyces sparsogenes var. sparsogenes (Owen, Dietz and Camiener, 1962). It has been isolated as crystalline material from the culture filtrates and has the molecular formula C31H21N3O6S2 (Argoudelis and Herr, 1962) but its structure is not yet known.

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References

  • Argoudelis, A. D., and R. R. Herr: Sparsomycin, a new antitumor antibiotic. II. Isolation and characterization. Antimicrobial Agents and Chemotherapy, p. 780 (1962).

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  • Biswas, B. B., M. Edmonds, and R. Abrams: Methylation of the purines of soluble RNA with methyl labeled methionine. Biochem. Biophys. Research Commun. 6, 146 (1961).

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  • Colombo, B., L. Felicetti, and C. Bagliono: Inhibition of protein synthesis by antibiotics in reticulocytes. Biochim. et Biophys. Acta (in press) (1965).

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  • Owen, S. P., A. Dietz, and G. W. Camiener: Sparsomycin, a new antitumor antibiotic. I. Discovery and biological properties. Antimicrobial Agents and Chemotherapy, p. 772 (1962).

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  • Pittillo, R. F., M. Lucas, C. Woolley, R. T. Blackwell, and C. Moncrief: Sparsomycin modification of the lethal action of ionizing irradiation on Escherichia coli. Nature 205, 773 (1965).

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  • Slechta, L.: Mode of action of sparsomycin in E. coli B. Antimicrobial Agents and Chemotherapy 326 (1965).

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Authors
  1. Libor Slechta
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Editor information

Editors and Affiliations

  1. University of Illinois, Urbana, Illinois, USA

    David Gottlieb (Professor of Plant Pathology) & Paul D. Shaw (Associate Professor of Biochemistry) (Professor of Plant Pathology) &  (Associate Professor of Biochemistry)

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© 1967 Springer-Verlag Berlin · Heidelberg

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Slechta, L. (1967). Sparsomycin. In: Gottlieb, D., Shaw, P.D. (eds) Mechanism of Action. Antibiotics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46051-7_29

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  • DOI: https://doi.org/10.1007/978-3-642-46051-7_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46053-1

  • Online ISBN: 978-3-642-46051-7

  • eBook Packages: Springer Book Archive

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