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Penicillins and Cephalosporins

  • Chapter
Mechanism of Action

Part of the book series: Antibiotics ((ANTIBIOTICS,volume 1))

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Abstract

The host environment is so different and complex compared to in vitro systems that to expect the mechanism of action of this or any other antibiotic agent to be sequentially identical in both environments is unreasonable. The relative importance of primary, secondary, or later effects as measured in the laboratory test tube may be markedly shifted by interactions of the host polyphasic system. To quote Hirsch (1965) “… The pathogenesis of infectious disease in many ways illustrates well the infinite complexity of biologic systems, with living things existing in a state of delicate balance under the constant influence of interactions between themselves and their environment.” Humoral and cellular mechanisms play varied and complex roles in the host resistance system, changing with such diverse factors as sex, age, hormonal influences, nutrition, intestinal microbial flora and, yes, even the weather (Coburn et al., 1957).

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Authors
  1. Carl W. Godzeski
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  2. Edwin H. Flynn
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Editors and Affiliations

  1. University of Illinois, Urbana, Illinois, USA

    David Gottlieb (Professor of Plant Pathology) & Paul D. Shaw (Associate Professor of Biochemistry) (Professor of Plant Pathology) &  (Associate Professor of Biochemistry)

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© 1967 Springer-Verlag Berlin · Heidelberg

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Godzeski, C.W., Flynn, E.H. (1967). Penicillins and Cephalosporins. In: Gottlieb, D., Shaw, P.D. (eds) Mechanism of Action. Antibiotics, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46051-7_2

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  • DOI: https://doi.org/10.1007/978-3-642-46051-7_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46053-1

  • Online ISBN: 978-3-642-46051-7

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