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Ductal Carcinoma In Situ of the Breast: Histological Classification and Genetic Alterations

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Adjuvant Therapy of Primary Breast Cancer VI

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 152))

Abstract

Ductal carcinoma in situ (DCIS) represents a proliferation of malignant epithelial cells within the ducts and lobules of the breast, without invasion through the basement membrane. It is assumed that most, if not all, invasive carcinomas are preceded by DCIS. It is, however, not known what proportion of DCIS, if left untreated, will progress to invasive carcinoma. Approximately 3% of all breast malignancies are DCIS. Because DCIS grows in pre-existing milk ducts without forming a tumour mass, a lot of cases are clinically asymptomatic. As a result of the formation of microcalcifications in the tumorous areas, many cases of DCIS are detected on the basis of these microcalcifications using mammography. With the increased use of mass population screening using mammography, more cases of DCIS are being detected. In most screening programs, 15%–25% of all detected malignancies are DCIS.

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  1. Department of Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    M. J. van de Vijver

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  1. M. J. van de Vijver
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  1. Zentrum für Tumordiagnostik und Prävention, Rorschacherstrasse 150, CH-9006, St. Gallen, Switzerland

    Hans-Jörg Senn

  2. Dana Farber Cancer Institute Biostatistics, 44 Binney Street, Boston, 02115, USA

    Richard D. Gelber Ph.D

  3. Ospedale Civico, CH-6900, Lugano, Switzerland

    Aron Goldhirsch

  4. Klinik C für Innere Medizin Abteilung für Onkologie und Hämatologie, Kantonsspital St. Gallen, CH-9007, St. Gallen, Switzerland

    Beat Thürlimann

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van de Vijver, M.J. (1998). Ductal Carcinoma In Situ of the Breast: Histological Classification and Genetic Alterations. In: Senn, HJ., Gelber, R.D., Goldhirsch, A., Thürlimann, B. (eds) Adjuvant Therapy of Primary Breast Cancer VI. Recent Results in Cancer Research, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45769-2_11

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