Abstract
Nowhere in urology has the philosophy of treatment for a particular disease, or the list of options for treatment, changed so markedly over a short period of time as it has for benign prostatic hyperplasia (BPH). In 1985, in the second tome on BPH published by the National Institutes of Health (NIH), following an NIH sponsored conference on the subject, Frank Hinman, Jr. expressed the prevailing philosophy, at least among urologists, regarding the treatment of BPH: “Men will choose between continuing medical therapy for the rest of their lives or having a one time operation” (Hinman 1985). At that time, a short 7 years ago, the “medical therapy” consisted only of side effect producing means of decreasing serum testosterone or interfering with its action and nonselective α-adrenergic blockade. A tabulation of the treatment options for BPH now available is seen in Table 1, a list that will probably be incomplete by the time of publication of this volume. Lest one think this is a “pie in the sky” list, only two of these options (growth factor inhibitor and pyrotherapy) could be listed as laboratory, experimental, or theoretical considerations, while the rest are in fact real and available options, most of which are being vigorously pursued by one or another commercial company. At the 1992 meeting of the American Urological Association (AUA), there were two courses on balloon dilatation, one course on the pharmacology of BPH, one course on nonsurgical management of BPH, one course on new nonmedical trends in the management of BPH, and one course on hyperthermia!
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abrams PH (1977) A double blind trial of the effects of candicidin on patients with benign prostatic hypertropy. Br J Urol 53:613
Abrams P (1985) Detrusor instability and bladder outlet obstruction. Neurourol Urodyn 4:317
Abrams PH, Griffiths DJ (1979) The assessment of prostatic obstruction from urodynamic measurements and from residual urine. Br J Urol 51:129
Anderson JT (1982) Prostatism: clinical, radiologic and urodynamic aspects. Neurourol Urodyn 1:241
Aso Y, Boccon-Gibod L, Colais DaSilva F, Chaussy C, Fowler J, Homma Y, Legrain M, Moriyama N, Richard F, Tazaki H (1991) Subjective response, objective response impact on quality of life. In: Cockett A, Aso Y, Chatelain et al. (eds) Proceedings of the international consultation on BPH, Digital Print, Ivry/Seine, France, 1991, pp 87–90
Ball AJ, Feneley RCL, Abrams PH (1981) The natural history of untreated “prostatism”. Br J Urol 53:613
Barry MJ, Mulley AG, Fowler FJ, Wennberg JW (1988) Watchful waiting versus immediate transurethral resection for symptomatic prostatism: the importance of patients’ perferences. JAMA 259:2010
Benson H, Epstein MD (1976) The placebo effect. JAMA 232:1225
Birch NC, Hurst G, Doyle PT (1988) Serial residual volumes in men with prostatic hypertrophy. Br J Urol 62:571
Blaivas JG (1989) Evaluation of bladder outlet obstruction. In: Paulsen DF (ed) Prostatic disorders. Lea and Febiger, Philadelphia, pp 173–192
Boyarsky S, Jones G, Paulson DF, Prout GR Jr (1977) A new look at bladder neck obstruction by the food and drug administration: guidelines for investigation of benign prostatic hypertrophy. Trans Am Assoc Genitourin Surg 68:29
Bruskewitz RC, Iverson P, Madsen PO (1982) Value of postvoid residual urine determination in evaluation of prostatism. Urology 20:602
Bruskewitz R, Jensen KME, Iversen P, Madsen PO (1983) The relevance of minimum urethral resistance in prostatism. J Urol 129:769
Claridge M (1983) Assessment of medical treatment. In: Hinman F Jr (ed) Benign Prostatic Hypertrophy. Springer, Berlin, Heidelberg New York, pp 308–312
Coolsaet B, Blok C (1986) Detrusor properties related to prostatism. Neurourol Urodyn 5:435
Dixon CM, Lepor H (1991) Transurethral dilatation of the prostate. Probl Urol 5(3):463
Drach GW, Layton T, Bottaccini MR (1982) A method of adjustment of male peak urinary flow rate for varying age and volume voided. J Urol 128:960
Fingl E, Woodbury DM (1975) General principles. In: Goodman LS, Gilman A (eds) The pharmacologic basis of therapeutics. Macmillan, New York, pp 1–46
Fowler FJ, Wennberg JE, Timothy RP, Barry MJ, Mulley AG, Hanley D (1988) Symptom status and quality of life following prostatectomy. JAMA 259:3018
Franks LM (1954) Benign hyperplasia of prostate. Ann Roy Coll Surg 14:92
Friedman LM, Furberg CD, DeMetz DL (1981) Fundamentals of clinical trials. Wright, Boston, pp 69–88
Geller J, Nelson CG, Pilbert JD, Pratt C (1979) Effect of megestrol acetate on uroflow rates in patients with benign prostatic hypertrophy. Urology 14:467
Graversen PH, Gasser TC, Wasson JH, Hinman F Jr, Bruskewitz RC (1989a) Controversies about indications for transurethral resection of the prostate. J Urol 141:475
Graversen PH, Bruskewitz RC, Madsen PO (1989b) The predictive value of urodynamic investigations for results following prostatectomy. In: Paulson DF (ed) Prostatic disorders, Lea and Febiger, Philadelphia, pp 232–245
Greenfield S (1989) The state of outcome research: are we on target? NEJM 320:1142
Haylen BT, Sabby D, Sutherst JR, Frazer MI, West CR (1989) Maximum and average urine flow rates in normal male and female populations-the Liverpool nomograms. Br J Urol 64:30
Heyns CF, de Klerk DP (1989) Pharmaceutical management of benign prostatic hyperplasia. In: Paulson DF (ed) Prostatic disorders. Lea and Febiger, Philadelphia, pp 204–231
Hinman F Jr (1983) Residual urine: measurement and influence in management of obstruction. In: Hinman F Jr (ed) Benign Prostatic Hypertrophy. Springer, Berlin Heidelberg New York, pp 589–596
Hinman, F., Jr. (1985) Overview — basis for clinical management, BPH, vol 2, NIH Publ 87-2881, Bethesda, p 205
Jensen KME (1989) Clinical evaluation of routine urodynamic investigations in prostatism. Neurourol Urodyn 8:545
Jensen KME, Jorgensen JB, Magnesen P (1988) Urodynamics in prostatism: II. Prognostic value of pressure-flow study combined with stop-flow test. Scand J Urol Nephrol [Suppl] 114:72
Kitada S, Ishisawa N (1981) Urethral pressure profilometry in the prospective assessment for prostatectomy. J Urol 126:89
Layton TM, Drach GW (1983) Urinary flow rates: measurement and adjustment. In: Hinman F Jr (ed) Benign Prostatic Hypertrophy. Springer, Berlin Heidelberg New York, pp 524–527
Lebacqz K (1979) Controlled clinical trials: some ethical issues. Controlled Clin Trials 1:29
Lytton B, Emery JM, Howard BM (1968). The incidence of benign prostatic obstruction. J Urol 99:639
Madsen PO, Iversen P (1983) A point system for selecting operative candidates. In: Hinman F Jr (ed) Benign Prostatic Hypertrophy. Springer, Berlin Heidelberg New York, pp 763–765
Mebust W, Roizo R, Schroeder F, Villers A (1991) Correlations between pathology, clinical symptoms and the course of the disease. In: Cockett A, Aso Y, Chatelain B et al. (eds) Proceedings of the international consultation on BPH, digital print, Ivry/Seine, France, pp 53–62
Peters CA, Walsh PC (1987) The effect of naferelin acetate, a leutinizing hormone releasing hormone agonist on benign prostatic hyperplasia. NEJM 317:599
Roos NP, Wennberg JE, Malenka DJ, Fisher ES, McPherson K, Andersen TF, Cohen MM, Ramsey E (1989) Mortality and reoperation after open and transurethral resection of the prostate for benign prostatic hyperplasia. NEJM 320:1120
Schafer W, Rubben H, Noppeney R, Deutz FJ (1989) Obstructed and unobstructed prostatic obstruction: a plea for urodynamic objectivation of bladder outflow obstruction in benign prostatic hyperplasia. World J Urol 6: 198
Siroky MB, Olsson CA, Krane RJ (1979) The flow rate nomogram: I. Development. J Urol 122:665
Siroky MB, Olsson CA, Krane RJ (1980) The flow rate nomogram: II. Clinical correlations. J Urol 123:208
Susset JG, Picker P, Kretz M, Jorest R (1973) Critical evaluation of uroflometers and analysis of normal curves. J Urol 109:874
Wein AJ (1981) Where are we: clinical trials. In: Zinner NR, Sterling AR (eds) Female incontinence, Liss, New York, pp 39–43
Wein AJ (1983) Principles for evaluation of pharmacologic agents. In: Hinman F Jr (ed) Benign Prostatic Hypertrophy. Springer, Berlin Heidelberg New York, pp 414–418
Wein AJ (1990) Evaluation of treatment response to drugs in benign prostatic hyperplasia. Urol Clin North Am 17(3):631
Wein AJ, Barrett DM (1988) Voiding function and dysfunction: a logical and practical approach. Year Book Medical Publishers, Chicago, pp 278–280 a
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Wein, A.J. (1993). Assessing Treatment Results for Benign Prostatic Hyperplasia. In: Romas, N.A., Vaughan, E.D. (eds) Alternate Methods in the Treatment of Benign Prostatic Hyperplasia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45723-4_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-45723-4_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-45725-8
Online ISBN: 978-3-642-45723-4
eBook Packages: Springer Book Archive