Abstract
One of the hallmarks of immunology has been analysis and characterization of the C system in biological fluids. It is composed of 11 proteins of the “classical” pathway:1 C1q, C1r, C1s, C4, C2, C3, C5, C6, C7, C8, and C9. There are three proteins of the “alternative” pathway (IUIS-WHO Nomenclature Committee 1981) B, D, and P. Finally, there are four control proteins: C1 inhibitor (Cl¯ INH) and C4b binding protein (C4b-bp) for the classical pathway, I (C3b inactivator or C3b INA) and H (β1 or C3b INA accelerator) for the alternative pathway, and anaphylatoxin inactivator. Due to the dramatic advances in protein chemistry, these 19 distinct serum proteins have been highly purified and characterized physiochemically (Table 1).
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© 1985 Springer-Verlag Berlin · Heidelberg
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Loos, M. (1985). The Complement System: Activation and Control. In: Loos, M. (eds) Bacteria and Complement. Current Topics in Microbiology and Immunology, vol 121. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45604-6_2
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DOI: https://doi.org/10.1007/978-3-642-45604-6_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-45606-0
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